Patents by Inventor Augusto De Barbieri

Augusto De Barbieri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Intravenous or intraperitoneal administration of a tripeptide compound for treating cancer
    Patent number: 4666887
    Abstract: A pharmaceutical composition for use in the treatment of malignant tumor cells in laboratory animals is disclosed. The pharmaceutical composition uses a pharmaceutically acceptable excipient with a tripeptide compound as the active ingredient. The tripeptide compound is formed from dichlorodiethylaminophenylalanine, parafluorophenylalanine, and methione.
    Type: Grant
    Filed: July 2, 1984
    Date of Patent: May 19, 1987
    Assignee: Proter S.p.A.
    Inventor: Augusto De Barbieri
  • Compounds of dichlorodiethylaminophenylalanine with anti-tumor activity
    Patent number: 4428875
    Abstract: Compounds with high anti-tumor activity and of moderate toxicity are described which are constituted by tripeptides formed from dichlorodiethylaminophenylalanine, para-fluorophenylalanine and methionine bonded together by peptide links.The tripeptides of the invention are particularly useful in the treatment of malignant tumors.
    Type: Grant
    Filed: October 15, 1981
    Date of Patent: January 31, 1984
    Assignee: Proter S.p.A.
    Inventor: Augusto De Barbieri
  • N-Acyl derivatives of glucosamine having antitumor chemotherapeutic acitivity
    Patent number: 4314999
    Abstract: N-acyl derivatives of D-hexosamine made by linking an oligopeptide having a m-di(2-chloroethyl)amino-L-phenylalanyl residue to the amino groups of two hexosamine molecules by a peptide bond, are endowed with strong antitumor action against transplanted neoplasms in animals. Compounds according to the present invention are: ##STR1## and its salts with organic or inorganic acids physiologically tolerated. The antineoplastic activity of the compounds of the present invention is not affected in the gastrointestinal tract and hence they can be effectively administered orally.
    Type: Grant
    Filed: July 30, 1980
    Date of Patent: February 9, 1982
    Assignee: Proter S.p.A.
    Inventor: Augusto De Barbieri
  • N-Acyl derivatives of glucosamines having antitumor chemotherapeutic activity
    Patent number: 4216208
    Abstract: N-Acyl derivatives of glucosamines made by linking an amino acid or oligopeptide having a m-di(2-chloroethyl)amino-L-phenylalanyl group, to the amino group of the glucosamines by a peptide bond, are endowed with strong anti-tumor action against transplanted neoplasma in animal. The compounds according to the present invention are of the general formula (I): ##STR1## where R.sub.1 is a hydrogen atom or an acetyl group,R.sub.2 is a hydrogen atom, an acetyl group, aliphatic (C.sub.1 -C.sub.6) group or a benzyl groupand R.sub.3 is m-di(2-chloroethyl) amino-L-phenylalanine, or L- methionyl -m-di(2-chloroethyl) amino-L-phenylalanyl-p-fluoro-L-phenylalanine, or p-fluoro-L-phenylalanyl-m-di (2-chloroethyl) amino-L-phenylalanyl-L-proline, or m-di (2-chloroethyl) amino-L-phenylalanyl-L-methionyl-p-fluoro-L-phenylalanine.The antineoplasmic activity of the compounds of the present invention is not affected in the gastrointestinal tract and hence they can be effectively administered orally.
    Type: Grant
    Filed: July 31, 1978
    Date of Patent: August 5, 1980
    Assignee: Proter S.p.A.
    Inventor: Augusto De Barbieri