Patents by Inventor Auinash KALSOTRA

Auinash KALSOTRA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multivalent ligand for myotonic dystrophy
    Patent number: 11242326
    Abstract: Abnormally long r(CUG)n repeat expansion is believed to be the major cause of Myotonic dystrophy type 1 (DM1) because it binds to muscleblind-like 1 (MBNL 1) protein which regulates RNA splicing, leading to the mis-splicing of more than 100 pre-mRNAs. The rational design of oligomers with alternating bisamidine and melamine structure resulted in good binding affinity to the RNA target because of a multivalent effect. The oligomers also showed excellent activity in disrupting nuclear foci, reversing the mis-splicing of IR minigene, and sabotaging the toxic RNA biosynthesis. Excellent activity in Drosophila based DM1 models was also observed for the oligomers, rescuing the climbing ability of the flies upon oral treatment.
    Type: Grant
    Filed: August 23, 2018
    Date of Patent: February 8, 2022
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Yugang Bai, Steven C. Zimmerman, Auinash Kalsotra
  • A MULTIVALENT LIGAND FOR MYOTONIC DYSTROPHY
    Publication number: 20200399231
    Abstract: Abnormally long r(CUG)n repeat expansion is believed to be the major cause of Myotonic dystrophy type 1 (DM1) because it binds to muscleblind-like 1 (MBNL 1) protein which regulates RNA splicing, leading to the mis-splicing of more than 100 pre-mRNAs. The rational design of oligomers with alternating bisamidine and melamine structure resulted in good binding affinity to the RNA target because of a multivalent effect. The oligomers also showed excellent activity in disrupting nuclear foci, reversing the mis-splicing of IR minigene, and sabotaging the toxic RNA biosynthesis. Excellent activity in Drosophila based DM1 models was also observed for the oligomers, rescuing the climbing ability of the flies upon oral treatment.
    Type: Application
    Filed: August 23, 2018
    Publication date: December 24, 2020
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: Yugang BAI, Steven C. ZIMMERMAN, Auinash KALSOTRA