Abstract: A method for locating at least one optical marker in a diffusing medium, the marker having at least one optical property different from the diffusing medium, wherein: a) a pulsed radiation interacts with the medium and the at least one optical marker, producing an optical signal, and at least one acquisition of data of the optical signal is performed, each acquisition including one or more time components of interest, due to the at least one marker, and a spurious component, due to the medium other than the at least one marker, b) a multidimensional array X is formed from the optical signal data of the at least one of the acquisitions, c) the array X is processed by factorization into a product of only two non-negative multidimensional arrays A and S, and d) at least one of the time components is extracted from the arrays A and S.

Abstract: A method is disclosed for locating at least one optical marker in a diffusing medium, said marker having at least one optical property different from the diffusing medium, method wherein: a) a pulsed radiation interacts with said medium and said at least one optical marker, producing an optical signal, and at least one acquisition of data of said optical signal is performed, each acquisition including one or more time components of interest, due to said at least one marker, and a spurious component, due to said medium other than said at least one marker, b) a multidimensional array X is formed from said optical signal data of said at least one of said acquisitions, c) said array X is processed by factorization into a product of only two non-negative multidimensional arrays A and S, d) at least one of said time components is extracted from said arrays A and S.

Abstract: A device and method for processing fluorescence signals emitted after excitation by radiation coming from a radiation source, by at least one fluorophore with a lifetime ? in a surrounding medium, which signals are detected by detection means, and which method includes the calculation, on the basis of detected fluorescence signals, of values of a variable, independent of ?, of the position or the distribution of fluorophore in said medium.

Abstract: A device and method for processing fluorescence signals emitted after excitation by radiation coming from a radiation source, by at least one fluorophore with a lifetime ? in a surrounding medium, which signals are detected by detection means, and which method includes the calculation, on the basis of detected fluorescence signals, of values of a variable, independent of ?, of the position or the distribution of fluorophore in said medium.

Abstract: A device and method for processing fluorescence signals emitted after excitation by radiation coming from a radiation source, by at least one fluorophore with a lifetime ? in a surrounding medium, which signals are detected by detection means, and which method includes the calculation, on the basis of detected fluorescence signals, of values of a variable, independent of ?, of the position or the distribution of fluorophore in said medium.

Abstract: The invention relates to a method for processing fluorescence signals emitted after excitation by radiation coming from a radiation source, by at least one fluorophore with a lifetime r in a surrounding medium, which signals are detected by detection means, and which method comprises the calculation, on the basis of detected fluorescence signals, of values of a variable, independent of ?, of the position or the distribution of fluorophore in said medium.