Patents by Inventor Aurelie Serrero
Aurelie Serrero has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210177567Abstract: A cardiovascular graft is provided with highly reduced thrombogenicity. The cardiovascular graft is an electrospun non-woven mesh produced from supramolecular polymers with large diameter fibers. The cardiovascular graft can be implemented as a vascular graft into the human body to allow vascular bypass/reconstruction, or repeated venous access for dialysis treatment, as well as other disorders of small-diameter blood vessels.Type: ApplicationFiled: February 24, 2021Publication date: June 17, 2021Inventors: Luke David Burke, Martijn Antonius Johannes Cox, Aurelie Serrero
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Patent number: 10953139Abstract: A biodegradable cardiovascular implant is provided for growing cardiovascular tissue in a patient. The implant distinguishes an electro-spun network with supramolecular compounds having hard-blocks covalently bonded with soft-blocks resulting in much enhanced durability and fatigue resistance, while maintaining the effectiveness as a cardiovascular implant.Type: GrantFiled: December 19, 2018Date of Patent: March 23, 2021Assignee: Xeltis AGInventors: Aurelie Serrero, Martijn Antonius Johannes Cox
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Patent number: 10815345Abstract: The present invention relates to a method for preparing a chitosan-based matrix (4) comprising the following steps: a) two separate chitosan porous layers (1, 2) obtained from lyophilisation of layers of one or more solutions of chitosan are provided, b) the chitosan porous layers of a) are neutralized and washed, c) a face (1a, 2a) of each chitosan porous layer is acidified with an acid, d) a fiber reinforcement member (3) is provided and positioned between the two acidified faces of the two chitosan porous layers, e) the two chitosan porous layers and the fiber reinforcement member are let to dry to obtain a matrix having the fiber reinforcement member embedded therein. The invention also relates to an implant comprising a matrix obtained according to such a method.Type: GrantFiled: January 9, 2019Date of Patent: October 27, 2020Assignee: SOFRADIM PRODUCTIONInventors: Aurelie Serrero, Mylene Desorme
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Patent number: 10624989Abstract: The present invention relates to an implant (10) comprising: a substrate (1) the surface of which comprising oxidized cellulose, said oxidized cellulose having a degree of oxidation ranging from 0.5 to 1, and a multilayer coating covering said substrate, said multilayer coating comprising at least a first layer (2) adjacent said substrate, said first layer being formed of chitosan, and a second layer (3) adjacent said first layer, said second layer being formed of oxidized cellulose having a degree of oxidation ranging from 0.5 to 1. The invention further relates to a method for preparing such an implant.Type: GrantFiled: May 29, 2019Date of Patent: April 21, 2020Assignee: Sofradim ProductionInventors: Aurelie Serrero, Robert Vestberg, Suzelei Montanari
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Publication number: 20190275202Abstract: The present invention relates to an implant (10) comprising: a substrate (1) the surface of which comprising oxidized cellulose, said oxidized cellulose having a degree of oxidation ranging from 0.5 to 1, and a multilayer coating covering said substrate, said multilayer coating comprising at least a first layer (2) adjacent said substrate, said first layer being formed of chitosan, and a second layer (3) adjacent said first layer, said second layer being formed of oxidized cellulose having a degree of oxidation ranging from 0.5 to 1. The invention further relates to a method for preparing such an implant.Type: ApplicationFiled: May 29, 2019Publication date: September 12, 2019Inventors: Aurelie Serrero, Robert Vestberg, Suzelei Montanari
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Publication number: 20190201588Abstract: A biodegradable cardiovascular implant is provided for growing cardiovascular tissue in a patient. The implant distinguishes an electro-spun network with supramolecular compounds having hard-blocks covalently bonded with soft-blocks resulting in much enhanced durability and fatigue resistance, while maintaining the effectiveness as a cardiovascular implant.Type: ApplicationFiled: December 19, 2018Publication date: July 4, 2019Inventors: Aurelie Serrero, Martijn Antonius Johannes Cox
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Patent number: 10328178Abstract: The present invention relates to an implant (10) comprising: —a substrate (1) the surface of which comprising oxidized cellulose, said oxidized cellulose having a degree of oxidation ranging from 0.0 to 1, and —a multilayer coating covering said substrate, said multilayer coating comprising at least a first layer (2) adjacent said substrate, said first layer being formed of chitosan, and a second layer (3) adjacent said first layer, said second layer being formed of oxidized cellulose having a degree of oxidation ranging from 0.5 to 1. The invention further relates to a method for preparing such an implant.Type: GrantFiled: May 29, 2015Date of Patent: June 25, 2019Assignee: Sofradim ProductionInventors: Aurelie Serrero, Robert Vestberg, Suzelei Montanari
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Publication number: 20190144618Abstract: The present invention relates to a method for preparing a chitosan-based matrix (4) comprising the following steps: a) two separate chitosan porous layers (1, 2) obtained from lyophilisation of layers of one or more solutions of chitosan are provided, b) the chitosan porous layers of a) are neutralized and washed, c) a face (1a, 2a) of each chitosan porous layer is acidified with an acid, d) a fiber reinforcement member (3) is provided and positioned between the two acidified faces of the two chitosan porous layers, e) the two chitosan porous layers and the fiber reinforcement member are let to dry to obtain a matrix having the fiber reinforcement member embedded therein. The invention also relates to an implant comprising a matrix obtained according to such a method.Type: ApplicationFiled: January 9, 2019Publication date: May 16, 2019Inventors: Aurelie Serrero, Mylene Desorme
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Patent number: 10184032Abstract: The present invention relates to a method for preparing a chitosan-based matrix comprising the following steps: a) two separate chitosan porous layers obtained from lyophilization of layers of one or more solutions of chitosan are provided, b) the chitosan porous layers of a) are neutralized and washed, c) a face of each chitosan porous layer is acidified with an acid, d) a fiber reinforcement member is provided and positioned between the two acidified faces of the two chitosan porous layers, e) the two chitosan porous layers and the fiber reinforcement member are let to dry to obtain a matrix having the fiber reinforcement member embedded therein. The invention also relates to an implant comprising a matrix obtained according to such a method.Type: GrantFiled: January 22, 2016Date of Patent: January 22, 2019Assignee: Sofradim ProductionInventors: Aurelie Serrero, Mylene Desorme
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Publication number: 20180325646Abstract: A cardiovascular graft is provided with highly reduced thrombogenicity. The cardiovascular graft is an electrospun non-woven mesh produced from supramolecular polymers with large diameter fibers. The cardiovascular graft can be implemented as a vascular graft into the human body to allow vascular bypass/reconstruction, or repeated venous access for dialysis treatment, as well as other disorders of small-diameter blood vessels.Type: ApplicationFiled: June 12, 2018Publication date: November 15, 2018Inventors: Luke David Burke, Martijn Antonius Johannes Cox, Aurelie Serrero
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Patent number: 10052400Abstract: The present invention relates to a method for preparing a neutralized matrix of non-antigenic collagenous material comprising the steps of: —a) preparing an acidic solution of non-antigenic collagenous material, —b) pouring the solution of a) into a mold in order to form a layer, —c) lyophilizing the layer of b) in order to obtain an acidic matrix of non-antigenic collagenous material, d) sterilizing the acidic matrix obtained in c) with ethylene oxide in order to obtain a neutralized matrix of non-antigenic collagenous material. The invention also relates to the matrices obtained and to surgical implants comprising such matrices.Type: GrantFiled: June 1, 2015Date of Patent: August 21, 2018Assignee: Sofradim ProductionInventors: Amandine Jaillon, Aurelie Serrero
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Patent number: 9750837Abstract: The present invention relates to a haemostatic patch comprising a porous layer based on oxidized cellulose and a neutralized film based on chitosan, said film comprising a free face and a face fixed on one of the faces of the porous layer, and to the method of preparing said patch comprising the following steps: —a°) preparing a porous layer based on oxidized cellulose, —b°) preparing a film based on chitosan starting from an acidic aqueous solution of chitosan, —c°) fixing the film obtained in b°) on one face of the porous layer, —d°) neutralizing the film obtained in b°), —where step c°) can be carried out before or after step d°), characterized in that: the neutralizing step d°) comprises treatment of said film with a neutralizing composition comprising at least ethanol and ammonium hydroxide (NH4OH).Type: GrantFiled: September 25, 2013Date of Patent: September 5, 2017Assignee: Sofradim ProductionInventors: Aurelie Serrero, Suzelei Montanari
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Publication number: 20170239387Abstract: The present invention relates to an implant (10) comprising: -a substrate (1) the surface of which comprising oxidized cellulose, said oxidized cellulose having a degree of oxidation ranging from 0.0 to 1, and -a multilayer coating covering said substrate, said multilayer coating comprising at least a first layer (2) adjacent said substrate, said first layer being formed of chitosan, and a second layer (3) adjacent said first layer, said second layer being formed of oxidized cellulose having a degree of oxidation ranging from 0.5 to 1. The invention further relates to a method for preparing such an implant.Type: ApplicationFiled: May 29, 2015Publication date: August 24, 2017Inventors: Aurelie Serrero, Robert Vestberg, Suzelei Montanari
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Publication number: 20170189574Abstract: The present invention relates to a method for preparing a neutralized matrix of non-antigenic collagenous material comprising the steps of:—a) preparing an acidic solution of non-antigenic collagenous material,—b) pouring the solution of a) into a mould in order to form a layer,—c) lyophilizing the layer of b) in order to obtain an acidic matrix of non-antigenic collagenous material, d) sterilizing the acidic matrix obtained in c) with ethylene oxide in order to obtain a neutralized matrix of non-antigenic collagenous material. The invention also relates to the matrices obtained and to surgical implants comprising such matrices.Type: ApplicationFiled: June 1, 2015Publication date: July 6, 2017Applicant: Sofradim ProductionInventors: Amandine Jaillon, Aurelie Serrero
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Publication number: 20160237228Abstract: The present invention relates to a method for preparing a chitosan-based matrix (4) comprising the following steps: a) two separate chitosan porous layers (1, 2) obtained from lyophilisation of layers of one or more solutions of chitosan are provided, b) the chitosan porous layers of a) are neutralized and washed, c) a face (1a, 2a) of each chitosan porous layer is acidified with an acid, d) a fiber reinforcement member (3) is provided and positioned between the two acidified faces of the two chitosan porous layers, e) the two chitosan porous layers and the fiber reinforcement member are let to dry to obtain a matrix having the fiber reinforcement member embedded therein. The invention also relates to an implant comprising a matrix obtained according to such a method.Type: ApplicationFiled: January 22, 2016Publication date: August 18, 2016Inventors: Aurelie Serrero, Mylene Desorme
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Patent number: 9247941Abstract: Implants include a film layer containing cellulose secured to a surface of the porous layer that also contains cellulose, wherein the film layer is secured to the porous cellulose without the use of an adhesive.Type: GrantFiled: April 28, 2011Date of Patent: February 2, 2016Assignee: Sofradim ProductionInventors: Suzelei Montanari, Aurelie Serrero
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Publication number: 20150202342Abstract: The present invention relates to a haemostatic patch comprising a porous layer based on oxidized cellulose and a neutralized film based on chitosan, said film comprising a free face and a face fixed on one of the faces of the porous layer, and to the method of preparing said patch comprising the following steps:—a°) preparing a porous layer based on oxidized cellulose,—b°) preparing a film based on chitosan starting from an acidic aqueous solution of chitosan,—c°) fixing the film obtained in b°) on one face of the porous layer,—d°) neutralizing the film obtained in b°),—where step c°) can be carried out before or after step d°), characterized in that: the neutralizing step d°) comprises treatment of said film with a neutralizing composition comprising at least ethanol and ammonium hydroxide (NH4OH).Type: ApplicationFiled: September 25, 2013Publication date: July 23, 2015Inventors: Aurelie Serrero, Suzelei Montanari
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Publication number: 20130103076Abstract: Implants include a film layer containing cellulose secured to a surface of the porous layer that also contains cellulose, wherein the film layer is secured to the porous cellulose without the use of an adhesive.Type: ApplicationFiled: April 28, 2011Publication date: April 25, 2013Inventors: Suzelei Montanari, Aurelie Serrero