Abstract: A system for non-invasive hematological measurements includes a platform to receive a body portion of a user and an imaging device to acquire a set of images of a capillary bed in the body portion. For each image, a controller detects one or more capillaries in the body portion of the finger to identify a first set of capillaries by estimating one or more attributes of each capillary (e.g., structural attributes, flow attributes, imaging attributes, or combinations thereof), wherein at least one attribute of each capillary meets a predetermined criterion. The controller also identifies a second set of capillaries from the first set of capillaries such that each capillary of the second set of capillaries is visible in a predetermined number of images of the set of images.

Abstract: In one aspect, a method to detect white blood cells and/or white blood cell subtypes from non-invasive capillary videos is featured. The method includes acquiring a first plurality of images of a region of interest including one or more capillaries of a predetermined area of a human subject from non-invasive capillary videos captured with an optical device, processing the first plurality of images to determine one or more optical absorption gaps located in said capillary, and annotating the first plurality of images with an indication of any optical absorption gap detected in the first plurality of images.

Abstract: In one aspect, a method to detect white blood cells and/or white blood cell subtypes from non-invasive capillary videos is featured. The method includes acquiring a first plurality of images of a region of interest including one or more capillaries of a predetermined area of a human subject from non-invasive capillary videos captured with an optical device, processing the first plurality of images to determine one or more optical absorption gaps located in said capillary, and annotating the first plurality of images with an indication of any optical absorption gap detected in the first plurality of images.

Abstract: An automated system for acquiring images of one or more capillaries in a capillary bed includes a platform for receiving a body portion of a subject, an imaging subsystem having a repositionable field of view and coupled to the platform to acquire images of at least a capillary bed of the body portion and a controller communicably coupled to the imaging subsystem to automatically reposition the field of view of the imaging subsystem to different areas of the capillary bed, and at each field of view within the capillary bed, activate the imaging subsystem to acquire images of one or more capillaries in the capillary bed.

Abstract: A system for non-invasive hematological measurements includes a platform to receive a body portion of a user and an imaging device to acquire a set of images of a capillary bed in the body portion. For each image, a controller detects one or more capillaries in the body portion of the finger to identify a first set of capillaries by estimating one or more attributes of each capillary (e.g., structural attributes, flow attributes, imaging attributes, or combinations thereof), wherein at least one attribute of each capillary meets a predetermined criterion. The controller also identifies a second set of capillaries from the first set of capillaries such that each capillary of the second set of capillaries is visible in a predetermined number of images of the set of images.

Abstract: A system for non-invasive hematological measurements includes a platform to receive a body portion of a user and an imaging device to acquire a set of images of a capillary bed in the body portion. For each image, a controller detects one or more capillaries in the body portion of the finger to identify a first set of capillaries by estimating one or more attributes of each capillary (e.g., structural attributes, flow attributes, imaging attributes, or combinations thereof), wherein at least one attribute of each capillary meets a predetermined criterion. The controller also identifies a second set of capillaries from the first set of capillaries such that each capillary of the second set of capillaries is visible in a predetermined number of images of the set of images.

Abstract: In one aspect, a method to detect white blood cells and/or white blood cell subtypes from non-invasive capillary videos is featured. The method includes acquiring a first plurality of images of a region of interest including one or more capillaries of a predetermined area of a human subject from non-invasive capillary videos captured with an optical device, processing the first plurality of images to determine one or more optical absorption gaps located in said capillary, and annotating the first plurality of images with an indication of any optical absorption gap detected in the first plurality of images.

Abstract: A system constructs a positional contour of a variably contoured surface using data from a 3D capture device. A processor captures data from a tangential orientation capture device and produces a set of relative orientations. The set of relative orientations is transformed with a set of orientation manifold transformer parameters to produce a set of low dimensional orientations. The set of low dimensional orientations and a trained mapping function definition are used to produce a low dimensional point cloud. The low dimensional point cloud is transformed with a set of point cloud manifold transformer parameters, producing a reconstructed synchronized rotationally invariant point cloud.

Abstract: A system for non-invasive hematological measurements includes a platform to receive a body portion of a user and an imaging device to acquire a set of images of a capillary bed in the body portion. For each image, a controller detects one or more capillaries in the body portion of the finger to identify a first set of capillaries by estimating one or more attributes of each capillary (e.g., structural attributes, flow attributes, imaging attributes, or combinations thereof), wherein at least one attribute of each capillary meets a predetermined criterion. The controller also identifies a second set of capillaries from the first set of capillaries such that each capillary of the second set of capillaries is visible in a predetermined number of images of the set of images.

Abstract: A system and method for reconstructing a positional contour of a variably contoured surface includes a plurality of positional sensors and a plurality of orientation sensor disposed upon the surface, a processor and a memory. The system captures a positional description of the surface and produces a rotationally-invariant point cloud, and captures a first absolute orientation description of the surface and produces a first set of relative orientations. The first rotationally-invariant point cloud is resampled with respect to the orientation description to produce a first synchronized rotationally-invariant point cloud. The first set of relative orientations and the first synchronized rotationally-invariant point cloud are transformed to produce respective sets of dimensional representations and manifold transformer parameters, which are mapped to produce a trained mapping function definition.

Abstract: Systems, apparatus, and methods for non-invasively detecting a white blood cell (WBC) event from in vivo capillary data may include obtaining a plurality of images, followed by specifying two-dimensional (2D) coordinates corresponding to internal contour and external contour of a capillary visible in the images. The two sets of 2D coordinates may be resampled to generate two sets of resampled coordinates, between which intermediate curves, including a middle curve, are generated. Curvilinear distances may be defined based on the middle curve. Intensity values, each of which corresponds to one of the images, one of the intermediate curves, and one of the curvilinear distances, may be extracted and transformed to the Radon domain. A plurality of maxima locations in the Radon domain corresponding to a flow trajectory inside the capillary may be identified. Detection of a visual gap in the flow trajectory inside the capillary indicates a WBC event.

Abstract: Systems, apparatus, and methods for non-invasively detecting a white blood cell (WBC) event from in vivo capillary data may include obtaining a plurality of images, followed by specifying two-dimensional (2D) coordinates corresponding to internal contour and external contour of a capillary visible in the images. The two sets of 2D coordinates may be resampled to generate two sets of resampled coordinates, between which intermediate curves, including a middle curve, are generated. Curvilinear distances may be defined based on the middle curve. Intensity values, each of which corresponds to one of the images, one of the intermediate curves, and one of the curvilinear distances, may be extracted and transformed to the Radon domain. A plurality of maxima locations in the Radon domain corresponding to a flow trajectory inside the capillary may be identified. Detection of a visual gap in the flow trajectory inside the capillary indicates a WBC event.