Patents by Inventor Aurelien GIMENEZ

Aurelien GIMENEZ has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method and device for assaying the interaction and dynamics of permeation of a molecule and a lipid bilayer
    Patent number: 11892406
    Abstract: A method of assaying the interaction of a molecule and a lipid bilayer is described. The method employs a microfluidic device comprising a substrate having at least one concave microcavity with a metallic surface defining an aperture and a liquid disposed within the microcavity, a lipid bilayer suspended across the aperture, and a microfluidic channel containing a liquid disposed on top of the substrate in fluid communication with the lipid bilayer. The method comprises the steps of passing a liquid containing a test molecule across the microfluidic channel, and monitoring lipid bilayer molecule interactions by plasmonically enhanced Raman or fluorescence spectroscopy configured for plasmonic enhancement of a detection signal evolving from the test molecule or lipid bilayer. Also described in a microfluidic device configured to perform the method of the invention.
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: February 6, 2024
    Assignee: DUBLIN CITY UNIVERSITY
    Inventors: Tia Keyes, Rokas Sakalys, Kiang Wei Kho, Agata Steplewska, Aurelien Gimenez, Nirod Kumar Sarangi
  • A METHOD AND DEVICE FOR ASSAYING THE INTERACTION AND DYNAMICS OF PERMEATION OF A MOLECULE AND A LIPID BILAYER
    Publication number: 20210247314
    Abstract: A method of assaying the interaction of a molecule and a lipid bilayer is described. The method employs a microfluidic device comprising a substrate having at least one concave microcavity with a metallic surface defining an aperture and a liquid disposed within the microcavity, a lipid bilayer suspended across the aperture, and a microfluidic channel containing a liquid disposed on top of the substrate in fluid communication with the lipid bilayer. The method comprises the steps of passing a liquid containing a test molecule across the microfluidic channel, and monitoring lipid bilayer molecule interactions by plasmonically enhanced Raman or fluorescence spectroscopy configured for plasmonic enhancement of a detection signal evolving from the test molecule or lipid bilayer. Also described in a microfluidic device configured to perform the method of the invention.
    Type: Application
    Filed: June 7, 2019
    Publication date: August 12, 2021
    Applicant: DUBLIN CITY UNIVERSITY
    Inventors: Tia KEYES, Rokas SAKALYS, Kiang Wei KHO, Agata STEPLEWSKA, Aurelien GIMENEZ, Nirod Kumar SARANGI