Patents by Inventor Aurni Bhatnagar

Aurni Bhatnagar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for designing a potential inhibitor of glutathione-aldehyde conjugate binding to aldose reductase
    Patent number: 7702430
    Abstract: Provided herein is a crystallized ternary structure of human aldose reductase (AR) bound to NADPH and ?-glutamyl-S-(1,2-dicarboxyethyl)cysteinylglycine (DCEG). Also provided are specific inhibitors of glutathione-aldehyde binding to aldose reductase which are designed via at least computer modeling of the ternary AR:NADPH:DCEG structure and methods of designing and of screening the inhibitors for inhibition of glutathione-aldehyde binding to aldose reductase.
    Type: Grant
    Filed: November 18, 2005
    Date of Patent: April 20, 2010
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Satish K. Srivastava, Aurni Bhatnagar, Kota V. Ramana
  • Structural-based inhibitors of the glutathione binding site in aldose reductase, methods of screening therefor and methods of use
    Publication number: 20060110814
    Abstract: Provided herein is a crystallized ternary structure of aldose reductase (AR) bound to NADPH and ?-glutamyl-S-(1,2-dicarboxyethyl)cysteinylglycine (DCEG). Also provided are specific inhibitors of glutathione-aldehyde binding to aldose reductase which are designed via at least computer modeling of the ternary AR:NADPH:DCEG structure and methods of designing and of screening the inhibitors for inhibition of glutathione-aldehyde binding to aldose reductase.
    Type: Application
    Filed: November 18, 2005
    Publication date: May 25, 2006
    Inventors: Satish Srivastava, Aurni Bhatnagar, Kota Ramana