Patents by Inventor Austin Gerard Smith

Austin Gerard Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Expression of the heterologous genes according to a targeted expression profile
    Patent number: 6150169
    Abstract: This invention relates to DNA constructs for inserting heterologous gene sequences into a host genome so as to obtain expression of the heterologous gene, to methods of inserting heterologous gene sequences into a host genome, and to organisms carrying modified host genomes. Specifically, the DNA constructs of this invention contain an expression unit of an internal ribosome binding site (IRES) coupled to a heterologous gene sequence. This expression unit is flanked at the 5' and 3' ends by DNA sequences that enable homologous recombination or integration of the construct with the DNA of a targeted host to obtain expression of the heterologous gene in the host.
    Type: Grant
    Filed: January 25, 1996
    Date of Patent: November 21, 2000
    Assignee: The University of Edinburgh
    Inventors: Austin Gerard Smith, Peter Scott Mountford, Richard Frank Lathe
  • Method of enriching for mammalian stem cells
    Patent number: 6146888
    Abstract: Mammalian stem cells are obtained and maintained in vitro whose genome has at least one nucleic acid construct encoding an antibiotic resistance gene operatively linked to a promoter specific for mammalian stem cells. The preferential expression of the antibiotic resistance gene in the stem cells results in the preferential survival of the stem cells in the presence of antibiotic.
    Type: Grant
    Filed: December 29, 1995
    Date of Patent: November 14, 2000
    Assignee: The University of Edinburgh
    Inventors: Austin Gerard Smith, Peter Scott Mountford