Abstract: The disclosure relates generally to molecular diagnostic devices configured to amplifying a single nucleotide polymorphism (SNP) locus and discriminate between two or more allelic variants of the SNP, indicating presence or absence of a target allele. In some embodiments, the molecular diagnostic devices are capable of detecting, at point-of-care, SNPs associated with resistance or susceptibility to antibiotic treatment of organism infections. In other aspects, the disclosure provides methods of treatment for disease or disorders (e.g. organism infections) where treatment is guided by presence or absence of an allele at a SNP locus as determined by such molecular diagnostic devices.

Abstract: A client premises digital subscriber line (DSL) modem having multi-mode capability is disclosed. In initialization, the modem estimates whether channel conditions are such that digital processing of the received data according to a lower data rate DSL standard, such as ADSL2, may result in a higher effective data rate than receipt and processing according to a higher data rate DSL standard, such as ADSL2+. If so, the DSL modem configures itself, such as by configuring its filter characteristics and sampling frequency, to receive and process data according to the lower data rate DSL standard; the transmitting modem, for example at a central office or service area interface, may continue to operate according to the higher data rate standard (with its bit loading corresponding to a subset of subchannels). The receiving DSL modem processes the payload data according to the lower standard, while processing control messages according to the higher standard.

Abstract: A system for, and method of, reducing noise estimation error during a digital subscriber line (DSL) communication session and a DSL modem incorporating the system or the method. In one embodiment, the system includes: (1) a memory configured to contain data regarding frequency-dependent noise estimation error experienced during a prior DSL communication session and (2) a noise injector coupled to the memory and configured to employ the data to introduce frequency-dependent synthetic noise during a training period of the DSL communication session.