Abstract: The present disclosure provides nanostructure compositions and methods of producing nanostructure compositions. The nanostructure compositions comprise at least one population of nanostructures, at least one reactive diluent, at least one anaerobic stabilizer, and optionally at least one organic resin. The present disclosure also provides nanostructure films comprising a nanostructure layer and methods of making nanostructure films.

Abstract: The present invention provides nanostructure compositions and methods of producing nanostructure compositions. The nanostructure compositions comprise a population of nanostructures, a stabilization additive, and an organic resin. The present invention also provides nanostructure films comprising a nanostructure layer and methods of making nanostructure films.

Abstract: The present invention provides quantum dot compositions and methods of producing quantum dot compositions. The quantum dot compositions comprise a population of quantum dots, a siloxane polymer, an emulsification additive, and an organic resin. The present invention also provides quantum dot films comprising a quantum dot layer and methods of making quantum dot films.

Abstract: A system includes a delivery server, an order server, and a database including consumer goods. The order server displays a website including the consumer goods to a customer and enables the customer to select consumer goods for purchase. The order server receives a request by the customer device to complete an order including the selected goods, receives a selection of a delivery time for the customer to receive the order, and transmits the order and delivery time to the delivery server. The delivery server receives a delivery acceptance notification indicating that a delivery driver has agreed to deliver the order to the customer. The delivery server also receives a check-in notification indicating that the delivery driver is estimated to arrive at the store in less than a threshold amount of time, and automatically places the order in a delivery queue for loading the order into the delivery vehicle.

Abstract: A system includes a database having a plurality of purchasable items. The system also includes an order server programmed to display a website including the purchasable items to a customer via a customer device and allow the customer to select the purchasable items for purchase. The selected items are added to an online order, and a request to complete the order is received from the customer device. A selection of a pick-up time for the customer to retrieve the order at a store is received. The online order and the selected pick-up time are transmitted to an order assembly server. The order assembly server is configured to begin assembling the selected purchasable items for pick-up at the store, receive a selection of an additional purchasable item to add to the selected pick-up time, and assemble the order and the additional purchasable item for pick-up at the selected pickup time.

Abstract: The invention provides methods and materials for resetting or sustaining a human stem cell in a “naïve” or “ground” state, based on the use of media including combinations of inhibitors. An example naïve culture medium comprises a PKC inhibitor, a MEK inhibitor. Also provided are methods of obtaining or propagating such cells, cells obtained using these methods, and novel culture media, which can be used in these methods.

Abstract: A releasable connection for coiled tubing drilling apparatus is presented wherein the connection has an outer body configured with an inner volume, a mandrel located at least partially within the outer body and in the inner volume, a plug located with the outer body and a structural weakpoint apparatus, wherein the structural weakpoint apparatus is configured to structurally fail at a predetermined tensile load placed upon the releasable connection apparatus, wherein the structural weakpoint apparatus is configured at a lower end of the mandrel.

Abstract: A releasable connection for coiled tubing drilling apparatus is presented wherein the connection has an outer body configured with an inner volume, a mandrel located at least partially within the outer body and in the inner volume, a plug located with the outer body and a structural weakpoint apparatus, wherein the structural weakpoint apparatus is configured to structurally fail at a predetermined tensile load placed upon the releasable connection apparatus, wherein the structural weakpoint apparatus is configured at a lower end of the mandrel.

Abstract: An extravascular system may include a fluid path and a gas vent in communication with the fluid path. A method of venting a medical device may include providing a closed extravascular system having a fluid path, providing a gas vent in communication with the fluid path, venting gas from the extravascular system through the gas vent, and maintaining closure of the extravascular system during and after venting.

Abstract: The tessellating elements are in sets and comprise (a) at least one curve element comprising a semi-circle of diameter x; (b) at least one wave element having a perimeter which is three-sided, including a first side which is straight and of length x, a second side which comprises a concave curve forming a semi-circle of diameter x, and a third side which comprises a convex curve forming a quarter circle of radius x; (c) at least one corner element having a perimeter which is three-sided, including two sides of length x at right angles to one another and a third side which is concave and comprises a quarter circle of radius x; and, optionally, (d) one or more lozenge elements having at least one shaped face with a perimeter comprising two arcuate edges, each said arcuate edge having a radius of curvature x. The elements have a wide range of applications, from building tiles and children's toys, to screen-filling of computer screens or the like.

Abstract: The present invention relates to the discovery that renewable stem cell lines can be derived from tumor cells and can be cultured in vitro. Accordingly, the invention provides neural tumor stem cell lines and cells from such cell lines. Because the cell lines retain characteristics of the tumors from which they are derived, the cells can be used in screening methods for identification of potential therapeutic agents and can be used to identify genetic markers which may be predictive for development of such tumors. Finally, such cells can be used to determine an appropriate therapeutic regimen for a patient suffering from a brain tumor. Cells from a patient's brain tumor can be cultured as described herein to create a cell line, and the relative effectiveness of a therapeutic agent against the cells can be tested to determine which agent or combination of agents is most effective in treating the patient's tumor.

Abstract: The tessellating elements are in sets and comprise (a) at least one curve element comprising a semi-circle of diameter x; (b) at least one wave element having a perimeter which is three-sided, including a first side which is straight and of length x, a second side which comprises a concave curve forming a semi-circle of diameter x, and a third side which comprises a convex curve forming a quarter circle of radius x; (c) at least one corner element having a perimeter which is three-sided, including two sides of length x at right angles to one another and a third side which is concave and comprises a quarter circle of radius x; and, optionally, (d) one or more lozenge elements having at least one shaped face with a perimeter comprising two arcuate edges, each said arcuate edge having a radius of curvature x. The elements have a wide range of applications, from building tiles and children's toys, to screen-filling of computer screens or the like.

Abstract: An extravascular system may include a fluid path and a gas vent in communication with the fluid path. A method of venting a medical device may include providing a closed extravascular system having a fluid path, providing a gas vent in communication with the fluid path, venting gas from the extravascular system through the gas vent, and maintaining closure of the extravascular system during and after venting.

Abstract: Pluripotent cells are derived and maintained in a self-renewing state in serum-free culture medium comprising a MEK inhibitor, a GSK3 inhibitor and an antagonist of an FGF receptor.

Abstract: Animal stem cells are obtained and maintained by culturing cells containing, in the genome, a selectable marker. Differential expression of the selectable marker enables preferential survival and/or division of the desired stem cells compared to the non-stem cells.

Abstract: Pluripotent cells are maintained in a self-renewing state in serum-free culture medium comprising a MEK inhibitor, a GSK3 inhibitor and, optionally, an antagonist of an FGF receptor. Pluripotent cells are also maintained in a self-renewing state in serum-free culture medium comprising a MEK inhibitor and an antagonist of an FGF receptor.

Abstract: A method for generating a culture that is purified or enriched in respect of cells of a selected lineage is described in which a selectable marker, which is differentially expressed in cells of the selected lineage compared with its expression in other cells, is introduced into a multipotential cell and the multipotential cell is cultured to induce differentiation of the multipotential cell into a cell of the selected lineage or into a mixture of cells including cells of the selected lineage, or is cultured to induce preferential survival of cells of the selected lineage. Those cells that express the selectable marker are then selected for. Progenitors of selected lineage are also described as is the use of the method in assay techniques.

Abstract: Self renewal of pluripotent cells in culture is promoted using a combination of an Id gene product and an activator of a gp130 downstream signalling pathway.