Patents by Inventor Austin Thiel

Austin Thiel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Islet cell manufacturing compositions and methods of use
    Patent number: 11945795
    Abstract: Disclosed herein are compositions and methods useful for manufacturing SC-? cell, and isolated populations of SC-? cells for use in various applications, such as cell therapy.
    Type: Grant
    Filed: May 1, 2020
    Date of Patent: April 2, 2024
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Austin Thiel, Jihad Yasin, Evrett Thompson, Felicia J. Pagliuca
  • COMPOSITIONS AND METHODS FOR CELLULAR REPROGRAMMING USING CIRCULAR RNA
    Publication number: 20230332182
    Abstract: Provided herein are recombinant circular RNAs comprising at least one protein-coding nucleic acid sequence, wherein the protein-coding nucleic acid sequence encodes a reprogramming factor (e.g., a transcription factor), wherein the reprogramming factor is Oct3/4, Klf4, Sox2, Nanog, Lin28, c-Myc, or L-Myc, or a fragment or variant thereof. Also provided herein are methods of producing induced pluripotent stem cells (iPSC), the method comprising contacting a somatic cell with at least one of the recombinant circular RNAs described herein and maintaining the cell under conditions under which a reprogrammed iPSC is obtained.
    Type: Application
    Filed: July 1, 2021
    Publication date: October 19, 2023
    Inventors: Santosh NARAYAN, Austin THIEL, Melissa CARPENTER, Mitchell Howard FINER, Miranda YANG, Cherylene PLEWA
  • METHODS OF ENHANCING STEM CELL DIFFERENTIATION INTO BETA CELLS
    Publication number: 20230146780
    Abstract: Disclosed herein are compositions and methods of enhancing stem cell differentiation into beta cells with use of one or more epigenetic modification compounds. The present disclosure also relates to compositions and methods of sorting and enriching the differentiated beta cells. The present disclosure also relates to compositions and methods of irradiating cell population for reducing proliferation.
    Type: Application
    Filed: November 11, 2022
    Publication date: May 11, 2023
    Inventors: Felicia PAGLIUCA, George HARB, Mads GURTLER, Austin THIEL, Jihad YASIN, Evrett THOMPSON
  • METHODS OF ENHANCING STEM CELL DIFFERENTIATION INTO BETA CELLS
    Publication number: 20230137854
    Abstract: Disclosed herein are compositions and methods of enhancing stem cell differentiation into beta cells with use of one or more epigenetic modification compounds. The present disclosure also relates to compositions and methods of sorting and enriching the differentiated beta cells. The present disclosure also relates to compositions and methods of irradiating cell population for reducing proliferation.
    Type: Application
    Filed: November 11, 2022
    Publication date: May 4, 2023
    Inventors: Felicia PAGLIUCA, George HARB, Mads GURTLER, Austin THIEL, Jihad YASIN, Evrett THOMPSON
  • METHODS OF ENHANCING STEM CELL DIFFERENTIATION INTO BETA CELLS
    Publication number: 20210198632
    Abstract: Disclosed herein are compositions and methods of enhancing stem cell differentiation into beta cells with use of one or more epigenetic modification compounds. The present disclosure also relates to compositions and methods of sorting and enriching the differentiated beta cells. The present disclosure also relates to compositions and methods of irradiating cell population for reducing proliferation.
    Type: Application
    Filed: September 2, 2020
    Publication date: July 1, 2021
    Inventors: Felicia Pagliuca, George Harb, Mads Gurtler, Jason Gaglia, Yeh-Chuin Poh, Lillian Ye, Austin Thiel, Jihad Yasin, Evrett Thompson
  • ISLET CELL MANUFACTURING COMPOSITIONS AND METHODS OF USE
    Publication number: 20210017157
    Abstract: Disclosed herein are compositions and methods useful for manufacturing SC-? cell, and isolated populations of SC-? cells for use in various applications, such as cell therapy.
    Type: Application
    Filed: May 1, 2020
    Publication date: January 21, 2021
    Inventors: Austin Thiel, Jihad Yasin, Evrett Thompson, Felicia J. Pagliuca