Abstract: Pyrrolobenzodiazepine (PBD) intermediates, including useful in the preparation of advanced intermediates. PBDs, and PBD dimers. Such PBD intermediates provide several advantages, including simplified synthesis of desired PBD products, greater substrate compatibility, and safer reaction conditions.

Abstract: A method of controlling a flow of a fluid through an inflow control device comprising a tubular within which a sliding sleeve having a longitudinal fluid passageway extends, the method includes longitudinally shifting the sliding sleeve, relative to the tubular, into a first, second, or third position, with each position associated with a different pressure differential between an external pressure applied to an external surface of the tubular with an internal pressure within the longitudinal fluid passage, and selecting a first, second, or third flow setting that corresponds with the first, second, and third pressure differential, respectively, at a surface of a well in which the inflow control device is received.

Abstract: A method of controlling a flow of a fluid through an inflow control device comprising a tubular within which a sliding sleeve having a longitudinal fluid passageway extends, the method includes longitudinally shifting the sliding sleeve, relative to the tubular, into a first, second, or third position, with each position associated with a different pressure differential between an external pressure applied to an external surface of the tubular with an internal pressure within the longitudinal fluid passage, and selecting a first, second, or third flow setting that corresponds with the first, second, and third pressure differential, respectively, at a surface of a well in which the inflow control device is received.