Patents by Inventor Avi Treves

Avi Treves has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR GENERATING INSULIN-PRODUCING BETA CELLS
    Publication number: 20220396774
    Abstract: Compositions and methods for generating insulin-producing beta cells from pluripotent stem cells are provided. The compositions and methods of the present invention involve stepwise differentiation while the differentiating cells are cultured on a lung tissue-derived acellular scaffold.
    Type: Application
    Filed: July 1, 2020
    Publication date: December 15, 2022
    Applicant: BETALIN THERAPEUTICS LTD.
    Inventors: Orit GOLDMAN, Nikolai KUNICHER, Manuela VECSLER, Avi TREVES
  • EXPANSION OF RENEWABLE STEM CELL POPULATIONS
    Publication number: 20180320139
    Abstract: Ex vivo and in vivo methods of expansion of renewable stem cells, expanded populations of renewable stem cells and their uses.
    Type: Application
    Filed: July 16, 2018
    Publication date: November 8, 2018
    Inventors: Tony Peled, Avi Treves, Oren Rosen
  • EXPANSION OF RENEWABLE STEM CELL POPULATIONS
    Publication number: 20160097037
    Abstract: Ex vivo and in vivo methods of expansion of renewable stem cells, expanded populations of renewable stem cells and their uses.
    Type: Application
    Filed: December 15, 2015
    Publication date: April 7, 2016
    Inventors: Tony Peled, Avi Treves, Oren Rosen
  • Methods of controlling proliferation and differentiation of stem and progenitor cells
    Patent number: 8202724
    Abstract: A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells. The method comprises ex-vivo providing the stem cells with conditions for cell proliferation and with at least one copper chelator in an amount and for a time period for permitting the stem cells to proliferate and, at the same time, for reducing a capacity of the stem cells to differentiate.
    Type: Grant
    Filed: October 6, 2010
    Date of Patent: June 19, 2012
    Assignees: Gamida Cell Ltd., Hadasit Medical Research Services and Development Ltd.
    Inventors: Tony Peled, Eitan Fibach, Avi Treves
  • Expansion of renewable stem cell populations
    Patent number: 7955852
    Abstract: Ex vivo and in vivo methods of expansion of renewable stem cells, expanded populations of renewable stem cells and their uses.
    Type: Grant
    Filed: February 9, 2004
    Date of Patent: June 7, 2011
    Assignee: Gamida Cell Ltd.
    Inventors: Tony Peled, Avi Treves, Oren Rosen
  • Methods Of Controlling Proliferation And Differentiation Of Stem And Progenitor Cells
    Publication number: 20110045589
    Abstract: A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells.
    Type: Application
    Filed: October 6, 2010
    Publication date: February 24, 2011
    Applicants: Gamida Cell LTD., Hadasit Medical Research Services And Development LTD.
    Inventors: Tony Peled, Eitan Fibach, Avi Treves
  • Expansion Of Renewable Stem Cell Populations
    Publication number: 20110033427
    Abstract: Ex vivo and in vivo methods of expansion of renewable stem cells, expanded populations of renewable stem cells and their uses.
    Type: Application
    Filed: October 20, 2010
    Publication date: February 10, 2011
    Applicant: Gamida Cell LTD.
    Inventors: Tony Peled, Avi Treves, Oren Rosen
  • Methods of controlling proliferation and differentiation of stem and progenitor cells
    Patent number: 7855075
    Abstract: A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells.
    Type: Grant
    Filed: May 19, 2008
    Date of Patent: December 21, 2010
    Assignees: Gamida Cell Ltd., Hadasit Medical Research Services and Development Ltd.
    Inventors: Tony Peled, Eitan Fibach, Avi Treves
  • Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby
    Patent number: 7655225
    Abstract: Ex vivo and in vivo methods of expanding a population of stem and/or progenitor cells, while at the same time reversibly inhibiting differentiation of the stem and/or progenitor cells by providing the stem and/or progenitor cells with an effective amount of at least one copper chelate, so as to maintain a free copper concentration available to said cells substantially unchanged, to thereby expand the population of said stem and/or progenitor cells, while at the same time reversibly inhibit differentiation of said stem and/or progenitor cells.
    Type: Grant
    Filed: February 19, 2008
    Date of Patent: February 2, 2010
    Assignee: Gamida Cell, Ltd.
    Inventors: Tony Peled, Avi Treves, Oren Rosen
  • Methods of controlling proliferation and differentiation of stem and progenitor cells
    Publication number: 20090004158
    Abstract: A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells.
    Type: Application
    Filed: May 19, 2008
    Publication date: January 1, 2009
    Inventors: Tony Peled, Eitan Fibach, Avi Treves
  • Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby
    Publication number: 20080279828
    Abstract: Ex vivo and in vivo methods of expanding a population of stem and/or progenitor cells, while at the same time reversibly inhibiting differentiation of the stem and/or progenitor cells by providing the stem and/or progenitor cells with an effective amount of at least one copper chelate, so as to maintain a free copper concentration available to said cells substantially unchanged, to thereby expand the population of said stem and/or progenitor cells, while at the same time reversibly inhibit differentiation of said stem and/or progenitor cells.
    Type: Application
    Filed: February 19, 2008
    Publication date: November 13, 2008
    Inventors: Tony Peled, Avi Treves, Oren Rosen
  • Methods of controlling proliferation and differentiation of stem and progenitor cells
    Patent number: 7429489
    Abstract: A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells. The method comprises ex-vivo providing the stem cells with conditions for cell proliferation and with at least one copper chelator in an amount and for a time period for permitting the stem cells to proliferate and, at the same time, for reducing a capacity of the stem cells to differentiate.
    Type: Grant
    Filed: October 14, 2004
    Date of Patent: September 30, 2008
    Assignees: Gamida Cell Ltd., Hadasit Medical Research Services and Development Ltd.
    Inventors: Tony Peled, Eitan Fibach, Avi Treves
  • Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby
    Patent number: 7344881
    Abstract: Ex vivo and in vivo methods of expanding a population of stem and/or progenitor cells, while at the same time reversibly inhibiting differentiation of the stem and/or progenitor cells by providing the stem and/or progenitor cells with an effective amount of at least one copper chelate, so as to maintain a free copper concentration available to said cells substantially unchanged, to thereby expand the population of said stem and/or progenitor cells, while at the same time reversibly inhibit differentiation of said stem and/or progenitor cells.
    Type: Grant
    Filed: April 18, 2003
    Date of Patent: March 18, 2008
    Assignee: Gamida Cell Ltd.
    Inventors: Tony Peled, Avi Treves, Oren Rosen
  • Methods of controlling proliferation and differentiation of stem and progenitor cells
    Patent number: 7312078
    Abstract: A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells. The method comprises ex-vivo providing the stem cells with conditions for cell proliferation and with at least one copper chelator in an amount and for a time period for permitting the stem cells to proliferate and, at the same time, for reducing a capacity of the stem cells to differentiate.
    Type: Grant
    Filed: March 18, 2005
    Date of Patent: December 25, 2007
    Assignees: Gamida Cell Ltd., Hadasit Medical Research Services and Development, Ltd.
    Inventors: Tony Peled, Eitan Fibach, Avi Treves
  • Methods of controlling proliferation and differentiation of stem and progenitor cells
    Patent number: 7169605
    Abstract: A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells.
    Type: Grant
    Filed: March 4, 2003
    Date of Patent: January 30, 2007
    Assignees: Gamida Cell Ltd., Hadasit Medical Research Services and Development Ltd.
    Inventors: Tony Peled, Eitan Fibach, Avi Treves
  • Methods of controlling proliferation and differentiation of stem and progenitor cells
    Patent number: 6962698
    Abstract: A method of expanding a population of cells, while at the same time inhibiting differentiation of the cells, the method includes the step of providing the cells with conditions for cell proliferation and, at the same time, for reducing a capacity of the cells in utilizing cooper. The method can be executed both in-vivo and ex-vivo. A method of inducing differentiation in a population of cells, the method includes the step of providing the cells with a transition metal chelator which binds copper and which is effective in inducing cell differentiation.
    Type: Grant
    Filed: August 17, 1999
    Date of Patent: November 8, 2005
    Assignees: Gamida Cell Ltd., Hadasit Medical Research Services and Development, Ltd.
    Inventors: Tony Peled, Eitan Fibach, Avi Treves
  • Methods of controlling proliferation and differentiation of stem and progenitor cells
    Publication number: 20050214262
    Abstract: A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells. The method comprises ex-vivo providing the stem cells with conditions for cell proliferation and with at least one copper chelator in an amount and for a time period for permitting the stem cells to proliferate and, at the same time, for reducing a capacity of the stem cells to differentiate.
    Type: Application
    Filed: March 18, 2005
    Publication date: September 29, 2005
    Inventors: Tony Peled, Eitan Fibach, Avi Treves
  • Methods of controlling proliferation and differentiation of stem and progenitor cells
    Publication number: 20050118150
    Abstract: A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells.
    Type: Application
    Filed: October 14, 2004
    Publication date: June 2, 2005
    Inventors: Tony Peled, Eitan Fibach, Avi Treves
  • Methods of controlling proliferation and differentiation of stem and progenitor cells
    Patent number: 6887704
    Abstract: A cell population cultured ex-vivo in a culture medium under conditions permitting cells of the cell population to proliferate and, at the same time, reducing a capacity of the cells in utilizing cooper, the cells are hence expanded yet not further differentiated as compared to ex-vivo seeded cells from which the cell population developed.
    Type: Grant
    Filed: November 13, 2001
    Date of Patent: May 3, 2005
    Assignee: Gamida Cell Ltd.
    Inventors: Tony Peled, Eitan Fibach, Avi Treves
  • EX-VIVO expansion of hematopoietic system cell populations in mononuclear cell cultures
    Publication number: 20050054097
    Abstract: Ex-vivo methods of expanding hematopoietic stem cells of hematopoietic mononuclear cells that comprise a major fraction of hematopoietic committed cells and a minor fraction of hematopoietic stem and progenitor cells, expanded populations of hematopoietic stem cells obtained thereby and their uses are disclosed.
    Type: Application
    Filed: January 29, 2004
    Publication date: March 10, 2005
    Inventors: Tony Peled, Avi Treves, Oren Rosen