Patents by Inventor Avijit PAUL

Avijit PAUL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SMAC/Diablo inhibitors useful for treating cancer
    Patent number: 11976280
    Abstract: The present invention relates to compositions and methods for treating cancer, particularly to agents that inhibit the expression and/or activity of the protein second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pI (SMAC/Diablo). The inhibiting agents include RNA interference molecules silencing the expression of SMAC/Diablo and peptides modulating its interactions within the cell nucleus and mitochondria. The methods and agents of the present invention are useful in treating cancers associated with overexpression of SMAC/Diablo.
    Type: Grant
    Filed: December 8, 2022
    Date of Patent: May 7, 2024
    Assignee: THE NATIONAL INSTITUTE FOR BIOTECHNOLOGY IN THE NEGEV LTD.
    Inventors: Varda Shoshan-Barmatz, Yakov Krelin, Avijit Paul
  • SMAC/DIABLO INHIBITORS USEFUL FOR TREATING CANCER
    Publication number: 20230265433
    Abstract: The present invention relates to compositions and methods for treating cancer, particularly to agents that inhibit the expression and/or activity of the protein second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pI (SMAC/Diablo). The inhibiting agents include RNA interference molecules silencing the expression of SMAC/Diablo and peptides modulating its interactions within the cell nucleus and mitochondria. The methods and agents of the present invention are useful in treating cancers associated with overexpression of SMAC/Diablo.
    Type: Application
    Filed: December 8, 2022
    Publication date: August 24, 2023
    Inventors: Varda SHOSHAN-BARMATZ, Yakov KRELIN, Avijit PAUL
  • SMAC/Diablo inhibitors useful for treating cancer
    Patent number: 11555192
    Abstract: The present invention relates to compositions and methods for treating cancer, particularly to agents that inhibit the expression and/or activity of the protein second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pI (SMAC/Diablo). The inhibiting agents include RNA interference molecules silencing the expression of SMAC/Diablo and peptides modulating its interactions within the cell nucleus and mitochondria. The methods and agents of the present invention are useful in treating cancers associated with overexpression of SMAC/Diablo.
    Type: Grant
    Filed: July 26, 2018
    Date of Patent: January 17, 2023
    Assignee: THE NATIONAL INSTITUTE FOR BIOTECHNOLOGY IN THE NEGEV LTD.
    Inventors: Varda Shoshan-Barmatz, Yakov Krelin, Avijit Paul
  • SMAC/DIABLO INHIBITORS USEFUL FOR TREATING CANCER
    Publication number: 20210261965
    Abstract: The present invention relates to compositions and methods for treating cancer, particularly to agents that inhibit the expression and/or activity of the protein second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pI (SMAC/Diablo). The inhibiting agents include RNA interference molecules silencing the expression of SMAC/Diablo and peptides modulating its interactions within the cell nucleus and mitochondria. The methods and agents of the present invention are useful in treating cancers associated with overexpression of SMAC/Diablo.
    Type: Application
    Filed: July 26, 2018
    Publication date: August 26, 2021
    Inventors: Varda SHOSHAN-BARMATZ, Yakov KRELIN, Avijit PAUL