Patents by Inventor Avital A. Rodal

Avital A. Rodal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for producing L-isoleucine
    Patent number: 6987017
    Abstract: The present invention relates, in general, to the over-production of L-isoleucine by nonhuman organisms. More specifically, the present invention relates to methods for producing L-isoleucine comprising: (a) growing a transformed nonhuman organism under conditions that provide for synthesis of L-isoleucine, wherein the nonhuman organism comprises one or more copies of a transgene comprising at least one nucleotide sequence encoding catabolic threonine dehydratase; wherein the L-isoleucine is synthesized by the transformed nonhuman organism, the synthesis being greater than that of the corresponding non-transformed nonhuman organism; and (b) recovering the L-isoleucine from the culture medium in which the transformed nonhuman organism was cultured.
    Type: Grant
    Filed: August 20, 2002
    Date of Patent: January 17, 2006
    Assignee: Massachusetts Institute of Technology
    Inventors: Stephane Guillouet, Anthony J. Sinskey, Avital A. Rodal, Philip A. Lessard
  • Methods for producing L-isoleucine
    Publication number: 20030008359
    Abstract: The present invention relates, in general, to the over-production of L-isoleucine by nonhuman organisms.
    Type: Application
    Filed: August 20, 2002
    Publication date: January 9, 2003
    Applicant: Massachussetts Institute of Technology
    Inventors: Stephane Guillouet, Anthony J. Sinskey, Avital A. Rodal, Philip A. Lessard
  • Methods for producing L-isoleucine
    Patent number: 6451564
    Abstract: The present invention relates, in general, to the over-production of L-isoleucine by nonhuman organisms. More specifically, the present invention relates to methods for producing L-isoleucine comprising: (a) growing a transformed nonhuman organism under conditions that provide for synthesis of L-isoleucine, wherein the nonhuman organism comprises one or more copies of a transgene comprising at least one nucleotide sequence encoding catabolic threonine dehydratase; wherein the L-isoleucine is synthesized by the transformed nonhuman organism, the synthesis being greater than that of the corresponding non-transformed nonhuman organism; and (b) recovering the L-isoleucine from the culture medium in which the transformed nonhuman organism was cultured.
    Type: Grant
    Filed: June 30, 2000
    Date of Patent: September 17, 2002
    Assignee: Massachusetts Institute of Technology
    Inventors: Stephane Guillouet, Avital A. Rodal, Philip A. Lessard, Anthony J. Sinskey