Patents by Inventor Aviva Breuer

Aviva Breuer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CANNABINOID DERIVATIVES AND THEIR USE THE TREATMENT OF INFLAMMATION AND/OR PAIN AND/OR OBESITY
    Publication number: 20240116883
    Abstract: The invention provides cannabinoid derivatives, methods of their preparation, compositions comprising them and uses thereof in the treatment of inflammation and/or pain and/or obesity.
    Type: Application
    Filed: November 24, 2021
    Publication date: April 11, 2024
    Applicant: Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.
    Inventors: Ruth GALLILY, Raphael MECHOULAM, Aviva BREUER, Natalya M KOGAN, Yarden LAVI, Zhanna YEKHTIN
  • Method for treating pain or associated condition or symptom
    Patent number: 11149014
    Abstract: Compositions that include certain phenyl substituted cyclohexenyl compounds are administered to a subject in a method for treating obesity or an associated disease or disorder or in a method of reducing food consumption or body weight.
    Type: Grant
    Filed: February 12, 2019
    Date of Patent: October 19, 2021
    Assignee: Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.
    Inventors: Ruth Gallily, Raphael Mechoulam, Aviva Breuer
  • Fluorinated CBD compounds, compositions and uses thereof
    Patent number: 10441553
    Abstract: The present invention relates to fluorine substituted CBD compounds, compositions thereof and uses thereof for the preparation of medicaments.
    Type: Grant
    Filed: August 1, 2017
    Date of Patent: October 15, 2019
    Assignees: UNIVERSIDADE DE SAO PAULO—USP, UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL—UFRGS, YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JESUSALEM LTD
    Inventors: Raphael Mechoulam, Antonio Waldo Zuardi, Flavio Pereira Kapczinski, Jaime Eduardo Cecilio Hallak, Francisco Silveira Guimaraes, Jose Alexandre de Souza Crippa, Aviva Breuer
  • METHOD FOR TREATING PAIN OR ASSOCIATED CONDITION OR SYMPTOM
    Publication number: 20190169148
    Abstract: Compositions that include certain phenyl substituted cyclohexenyl compounds are administered to a subject in a method for treating obesity or an associated disease or disorder or in a method of reducing food consumption or body weight.
    Type: Application
    Filed: February 12, 2019
    Publication date: June 6, 2019
    Inventors: Ruth Gallily, Raphael Mechoulam, Aviva Breuer
  • Cyclohexenyl compounds, compositions comprising them and uses thereof
    Patent number: 10239848
    Abstract: Compositions that include certain phenyl substituted cyclohexenyl compounds are administered to a subject in a method for treating obesity or an associated disease or disorder or in a method of reducing food consumption or body weight.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: March 26, 2019
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Ruth Gallily, Raphael Mechoulam, Aviva Breuer
  • FLUORINATED CBD COMPOUNDS, COMPOSITIONS AND USES THEREOF
    Publication number: 20190084909
    Abstract: The present invention relates to fluorine substituted CBD compounds, compositions thereof and uses thereof for the preparation of medicaments.
    Type: Application
    Filed: July 15, 2016
    Publication date: March 21, 2019
    Inventors: Raphael Mechoulam, Flavio Pereira Kapczinski, Jose Alexandre De Souza Crippa, Antonio Waldo Zuardi, Jaime Eduardo Cecilio Hallak, Francisco Silveira Guimaraes, Aviva Breuer
  • FLUORINATED CBD COMPOUNDS, COMPOSITIONS AND USES THEREOF
    Publication number: 20170326078
    Abstract: The present invention relates to fluorine substituted CBD compounds, compositions thereof and uses thereof for the preparation of medicaments.
    Type: Application
    Filed: August 1, 2017
    Publication date: November 16, 2017
    Inventors: Raphael MECHOULAM, Antonio Waldo ZUARDI, Flavio Pereira KAPCZINSKI, Jaime Eduardo Cecilio HALLAK, Francisco Silveira GUIMARAES, Jose Alexandre de Souza CRIPPA, Aviva BREUER
  • Fluorinated CBD compounds, compositions and uses thereof
    Patent number: 9782360
    Abstract: The present invention relates to fluorine substituted CBD compounds, compositions thereof and uses thereof for the preparation of medicaments.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: October 10, 2017
    Assignees: UNIVERSIDADE DE SAO PAULO—USP, UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL—UFRGS, YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD
    Inventors: Raphael Mechoulam, Antonio Waldo Zuardi, Flavio Pereira Kapczinski, Jaime Eduardo Cecilio Hallak, Francisco Silveira Guimaraes, Jose Alexandre de Souza Crippa, Aviva Breuer
  • FLUORINATED CBD COMPOUNDS, COMPOSITIONS AND USES THEREOF
    Publication number: 20170197904
    Abstract: The present invention relates to fluorine substituted CBD compounds, compositions thereof and uses thereof for the preparation of medicaments.
    Type: Application
    Filed: August 19, 2016
    Publication date: July 13, 2017
    Inventors: Raphael MECHOULAM, Antonio Waldo ZUARDI, Flavio Pereira KAPCZINSKI, Jaime Eduardo Cecilio HALLAK, Francisco Silveira GUIMARAES, Jose Alexandre de Souza CRIPPA, Aviva BREUER
  • CYCLOHEXENYL COMPOUNDS, COMPOSITIONS COMPRISING THEM AND METHODS
    Publication number: 20170029391
    Abstract: The present invention is directed to phenyl substituted cyclohexenyl compounds, compositions comprising them and uses thereof for the preparation of medicaments for the treatment of obesity and any disease or disorder associated therewith, for reduction in food consumption, and for the treatment of inflammation and disorders associated therewith.
    Type: Application
    Filed: October 13, 2016
    Publication date: February 2, 2017
    Inventors: Ruth GALLILY, Raphael MECHOULAM, Aviva BREUER
  • Fluorinated CBD compounds, compositions and uses thereof
    Patent number: 9447019
    Abstract: The present invention relates to fluorine substituted CBD compounds, compositions thereof and uses thereof for the preparation of medicaments.
    Type: Grant
    Filed: January 8, 2014
    Date of Patent: September 20, 2016
    Assignees: UNIVERSIDADE DE SAO PAULO-USP, UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL-UFRGS, YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD
    Inventors: Raphael Mechoulam, Antonio Waldo Zuardi, Flavio Pereira Kapczinski, Jaime Eduardo Cecilio Hallak, Francisco Silveira Guimaraes, Jose Alexandre de Souza Crippa, Aviva Breuer
  • Compositions comprising CB receptor agonists, uses thereof and methods for their preparation
    Patent number: 9428431
    Abstract: Provided are compositions including (3R, 4R, 6R)-stereoisomers of phenyl substituted pinenes having CB receptor agonist properties, methods of treating diseases or disorders with the pharmaceutical compositions, and processes for their preparation are also provided.
    Type: Grant
    Filed: October 11, 2009
    Date of Patent: August 30, 2016
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd.
    Inventors: Itai Bab, Raphael Mechoulam, Aviva Breuer, Naama Mussai
  • FLUORINATED CBD COMPOUNDS, COMPOSITIONS AND USES THEREOF
    Publication number: 20150344403
    Abstract: The present invention relates to fluorine substituted CBD compounds, compositions thereof and uses thereof for the preparation of medicaments.
    Type: Application
    Filed: January 8, 2014
    Publication date: December 3, 2015
    Inventors: Raphael MECHOULAM, Antonio Waldo ZUARDI, Flavio Pereira KAPCZINSKI, Jaime Eduardo Cecilio HALLAK, Francisco Silveira GUIMARAES, Jose Alexandre de Souza CRIPPA, Aviva BREUER
  • Anti-nausea and anti-vomiting activity of cannabidiol compounds
    Patent number: 8119697
    Abstract: The present invention relates the use of certain cannabidiol derivatives and of their dimethyl heptyl homologs (CBD-DMH) in the treatment of nausea, in particular chemotherapy-induced nausea, and of anti vomiting activity. The present invention relates also to the use of said cannabidiol derivatives being part of a pharmaceutical composition.
    Type: Grant
    Filed: June 16, 2006
    Date of Patent: February 21, 2012
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Raphael Mechoulam, Linda Parker, Aviva Breuer
  • COMPOSITIONS COMPRISING CB RECEPTOR AGONISTS, USES THEREOF AND METHODS FOR THEIR PREPARATION
    Publication number: 20110269842
    Abstract: Provided are compositions including (3R, 4R, 6R)-stereoisomers of phenyl substituted pinenes having CB receptor agonist properties, methods of treating diseases or disorders with the pharmaceutical compositions, and processes for their preparation are also provided.
    Type: Application
    Filed: October 11, 2009
    Publication date: November 3, 2011
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd.
    Inventors: Itai Bab, Raphael Mechoulam, Aviva Breuer, Naama Mussai
  • Pharmaceutical compositions comprising cannabidiol derivatives
    Patent number: 7759526
    Abstract: The present invention relates to cannabidiol derivatives and to pharmaceutical compositions comprising cannabidiol derivatives being antiinflammatory agents having analgesic, antianxiety, anticonvulsive, neuroprotective, antipsychotic and anticancer activity. The present invention also relates to a process for the preparation of cannabidiol derivatives. It also relates to the use of cannabidiol derivatives and of pharmaceutical compositions comprising same in the preparation of a medicament, in a method of the treatment of human beings with cannabidiol derivatives or with a pharmaceutical preparations comprising same.
    Type: Grant
    Filed: June 12, 2001
    Date of Patent: July 20, 2010
    Assignee: Yissum Research Development Company
    Inventors: Raphael Mechoulam, Susana Tchilibon, Ester Fride, Lumir Hanus, Aviva Breuer, Ruth Gallily
  • Agonists specific for the peripheral cannabinoid receptor
    Patent number: 7214716
    Abstract: The invention provides novel pharmaceutical compositions comprising as the active ingredient 4-phenyl pinene derivatives which are specific for the peripheral cannabinoid receptors. In particular, the compounds of the invention binds efficiently to CB2 but do not bind to CB1. The compounds show no activity in behavioral tests in mice which together have been shown to be specific for tetrahydrocannabinol (THC)- type activity in the central nervous system mediated by CB1 but reduce blood pressure, block intestinal motility, and elicit anti-inflammatory and peripheral analgetic activity. The invention also relates to methods of treating, preventing, or managing hypertension, inflammation, pain, gastrointestinal diseases, autoimmune diseases, and tumors with the compounds of the invention.
    Type: Grant
    Filed: January 27, 2005
    Date of Patent: May 8, 2007
    Assignee: Yissum Research Development Co. of the Hebrew University of Jerusalem
    Inventors: Ester Fride, Aviva Breuer, Lumir Hanus, Susanna Tchilibon, Michal Horowitz, Raphael Mechoulam, Aaron Garzon
  • Anti-nausea and anti-vomiting activity of cannabidiol compounds
    Publication number: 20070049645
    Abstract: The present invention relates the use of certain cannabidiol derivatives and of their dimethyl heptyl homologs (CBD-DMH) in the treatment of nausea, in particular chemotherapy-induced nausea, and of anti vomiting activity. The present invention relates also to the use of said cannabidiol derivatives being part of a pharmaceutical composition.
    Type: Application
    Filed: June 16, 2006
    Publication date: March 1, 2007
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Raphael Mechoulam, Linda Parker, Aviva Breuer
  • Agonists specific for the periperal cannabinoid receptor
    Publication number: 20050165118
    Abstract: The invention provides novel pharmaceutical compositions comprising as the active ingredient 4-phenyl pinene derivatives which are specific for the peripheral cannabinoid receptors. In particular, the compounds of the invention binds efficiently to CB2 but do not bind to CB1. The compounds show no activity in behavioral tests in mice which together have been shown to be specific for tetrahydrocannabinol (THC)-type activity in the central nervous system mediated by CB1 but reduce blood pressure, block intestinal motility, and elicit anti-inflammatory and peripheral analgetic activity. The invention also relates to methods of treating, preventing, or managing hypertension, inflammation, pain, gastrointestinal diseases, autoimmune diseases, and tumors with the compounds of the invention.
    Type: Application
    Filed: January 27, 2005
    Publication date: July 28, 2005
    Applicant: YISSUM RESEARCH DEVELOPMENT CO. OF THE HEBREW UNIVERSITY OF JERUSALEM
    Inventors: Ester Fride, Aviva Breuer, Lumir Hanus, Susanna Tchilibon, Michal Horowitz, Raphael Mechoulam, Aaron Garzon
  • Agonists specific for the peripheral cannabinoid receptor
    Patent number: 6903137
    Abstract: The invention provides novel pharmaceutical compositions comprising as the active ingredient 4-phenyl pinene derivatives which are specific for the peripheral cannabinoid receptors. In particular, the compounds of the invention binds efficiently to CB2 but do not bind to CB1. The compounds show no activity in behavioral tests in mice which together have been shown to be specific for tetrahydrocannabinol (THC)-type activity in the central nervous system mediated by CB1 but reduce blood pressure, block intestinal motility, and elicit anti-inflammatory and peripheral analgetic activity. The invention also relates to methods of treating, preventing, or managing hypertension, inflammation, pain, gastrointestinal diseases, autoimmune diseases, and tumors with the compounds of the invention.
    Type: Grant
    Filed: April 26, 2002
    Date of Patent: June 7, 2005
    Assignee: Yissum Research Development Co. of the Hebrew University of Jerusalem
    Inventors: Ester Fride, Aviva Breuer, Lumir Hanus, Susanna Tchilibon, Michal Horowitz, Raphael Mechoulam, Aaron Garzon