Patents by Inventor Aviva Joseph

Aviva Joseph has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sphingoid polyalkylamine conjugates for vaccination
    Patent number: 8673285
    Abstract: The present invention concerns the use of a sphingoid-polyalkylamine conjugate as a capturing agent of biologically active molecules, such as antigens. In a particular embodiment, the spinogid-polyalkylamines are used for the preparation of pharmaceutical composition for modulating the immune response of a subject. Other aspects of the invention concern methods for modulating the immune response of a subject by the use of the conjugate, complexes comprising, the sphingoid-polyalkylamine conjugate in combination with a biologically active molecule capable of modulating an immune response of a subject, compositions comprising the conjugate as well as kits making use of said conjugate. A preferred conjugate according to the invention is N palmitoyl D-erythro sphingosyl 1 carbamoyl spermine.
    Type: Grant
    Filed: June 17, 2004
    Date of Patent: March 18, 2014
    Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Biolab Ltd.
    Inventors: Yechezkel Barenholz, Aviva Joseph, Eliezer Kedar
  • Sphingoid polyalkylamine conjugates for vaccination
    Publication number: 20060252717
    Abstract: The present invention concerns the use of a sphingoid-polyalkylamine conjugate as a capturing agent of biologically active molecules, such as antigens. In a particular embodiment, the spinogid-polyalkylamines are used for the preparation of pharmaceutical composition for modulating the immune response of a subject. Other aspects of the invention concern methods for modulating the immune response of a subject by the use of the conjugate, complexes comprising, the sphingoid-polyalkylamine conjugate in combination with a biologically active molecule capable of modulating an immune response of a subject, compositions comprising the conjugate as well as kits making use of said conjugate. A preferred conjugate according to the invention is N palmitoyl D-erythro sphingosyl 1 carbamoyl spermine.
    Type: Application
    Filed: June 17, 2004
    Publication date: November 9, 2006
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Yechezkel Barenholz, Aviva Joseph, Eliezer Kedar
  • Method for preparation of vesicles loaded with biological material and different uses thereof
    Publication number: 20060029655
    Abstract: The present invention discloses a method for an efficient entrapment of active biological material in liposomes. The method is based on the steps of drying a suspension of liposome-forming lipids and then hydrating the dry composition obtained with an aqueous solution containing a biologically active material to be entrapped in high yield in the liposomes thus formed. The invention also concerns liposomal formulations produced by the method of the invention and their uses.
    Type: Application
    Filed: June 25, 2002
    Publication date: February 9, 2006
    Applicant: Yissum Research Development Company Of The Hebrew University Of Jerusalem
    Inventors: Yechezkel Barenholz, Eliezer Kedar, Aviva Joseph