Patents by Inventor Avner ADINI

Avner ADINI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROMININ-1 PEPTIDE FOR TREATING LUNG INJURY
    Publication number: 20200230199
    Abstract: Described herein are compositions and methods for treating a lung disorder associated with dysregulated VEGF signaling. The PR1P peptide (DRVQRQTTTVVA, SEQ ID NO: 1) and variants thereof are able to enhance VEGF signaling in the lungs and reduce lung cell apoptosis (e.g., induced by toxicity or injury), thus treating the disorder.
    Type: Application
    Filed: June 1, 2018
    Publication date: July 23, 2020
    Applicant: Children's Medical Center Corporation
    Inventors: Avner Adini, Benjamin Matthews
  • Pro-angiogenic fragments of prominin-1 and uses thereof
    Patent number: 10286032
    Abstract: Described have herein are peptide analogs of a prominin-1 peptide, DRVQRQTTTVVA (SEQ. ID. NO:1) which have enhanced regenerative and/or angiogenesis activity, increase VEGF binding to endothelial cells, and/or increase wound healing activity relative to the peptide of SEQ ID NO: 1. Provided herein are fusion proteins and compositions comprising these peptide analogs and uses thereof.
    Type: Grant
    Filed: June 22, 2015
    Date of Patent: May 14, 2019
    Assignee: Children's Medical Center Corporation
    Inventors: Avner Adini, Robert D'Amato
  • Prominin-1 peptide fragments and uses thereof
    Patent number: 9597371
    Abstract: Described herein are peptide compositions of a prominin-1, which have regenerative activity. As such the peptides are useful when regeneration is needed, for example, to enhance angiogenesis, increase VEGF binding to endothelial cells, promote vasodilation, enhance cell migration, enhance cell proliferation, stimulate neuronal growth, prevent neurodegeneration, and/or promote neuroregeneration.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: March 21, 2017
    Assignee: Children's Medical Center Corporation
    Inventors: Avner Adini, Robert D'Amato
  • PRO-ANGIOGENIC FRAGMENTS OF PROMININ-1 AND USES THEREOF
    Publication number: 20150359842
    Abstract: Described have herein are peptide analogs of a prominin-1 peptide, DRVQRQTTTVVA (SEQ. ID. NO:1) which have enhanced regenerative and/or angiogenesis activity, increase VEGF binding to endothelial cells, and/or increase wound healing activity relative to the peptide of SEQ ID NO: 1. Provided herein are fusion proteins and compositions comprising these peptide analogs and uses thereof.
    Type: Application
    Filed: June 22, 2015
    Publication date: December 17, 2015
    Inventors: Avner Adini, Robert D'Amato
  • Pro-angiogenic fragments of prominin-1 and uses thereof
    Patent number: 9090707
    Abstract: Described have herein are peptide analogs of a prominin-1 peptide, DRVQRQTTTVVA (SEQ. ID. NO:1) which have enhanced regenerative and/or angiogenesis activity, increase VEGF binding to endothelial cells, and/or increase wound healing activity relative to the peptide of SEQ ID NO: 1. Provided herein are fusion proteins and compositions comprising these pep tide analogs and uses thereof.
    Type: Grant
    Filed: January 27, 2011
    Date of Patent: July 28, 2015
    Assignee: Children's Medical Center Corporation
    Inventors: Avner Adini, Robert D'Amato
  • PROMININ-1 PEPTIDE FRAGMENTS AND USES THEREOF
    Publication number: 20140194358
    Abstract: Described herein are peptide compositions of a prominin-1, which have regenerative activity. As such the peptides are useful when regeneration is needed, for example, to enhance angiogenesis, increase VEGF binding to endothelial cells, promote vasodilation, enhance cell migration, enhance cell proliferation, stimulate neuronal growth, prevent neurodegeneration, and/or promote neuroregeneration.
    Type: Application
    Filed: October 28, 2013
    Publication date: July 10, 2014
    Applicant: Children's Medical Center Corporation
    Inventors: Avner Adini, Robert D'Amato
  • Prominin-1 peptide fragments and uses thereof
    Patent number: 8618055
    Abstract: Described herein are peptide compositions of a prominin-1, which have regenerative activity. As such the peptides are useful when regeneration is needed, for example, to enhance angiogenesis, increase VEGF binding to endothelial cells, promote vasodilation, enhance cell migration, enhance cell proliferation, stimulate neuronal growth, prevent neurodegeneration, and/or promote neuroregeneration.
    Type: Grant
    Filed: January 27, 2011
    Date of Patent: December 31, 2013
    Assignee: Children's Medical Center Corporation
    Inventors: Avner Adini, Robert D'Amato
  • PRO-ANGIOGENIC FRAGMENTS OF PROMININ-1 AND USES THEREOF
    Publication number: 20130045922
    Abstract: Described have herein are peptide analogs of a prominin-1 peptide, DRVQRQTTTVVA (SEQ. ID. NO:1) which have enhanced regenerative and/or angiogenesis activity, increase VEGF binding to endothelial cells, and/or increase wound healing activity relative to the peptide of SEQ ID NO: 1. Provided herein are fusion proteins and compositions comprising these pep tide analogs and uses thereof.
    Type: Application
    Filed: January 27, 2011
    Publication date: February 21, 2013
    Applicant: CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Avner Adini, Robert D'Amato
  • PROMININ-1 PEPTIDE FRAGMENTS AND USES THEREOF
    Publication number: 20110190210
    Abstract: Described herein are peptide compositions of a prominin-1, which have regenerative activity. As such the peptides are useful when regeneration is needed, for example, to enhance angiogenesis, increase VEGF binding to endothelial cells, promote vasodilation, enhance cell migration, enhance cell proliferation, stimulate neuronal growth, prevent neurodegeneration, and/or promote neuroregeneration.
    Type: Application
    Filed: January 27, 2011
    Publication date: August 4, 2011
    Applicant: CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Avner ADINI, Robert D'AMATO