Patents by Inventor Avner EHRLICH

Avner EHRLICH has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240263147
    Abstract: The present invention provides a method of treating a disease or disorder characterized by electro-mitochondrial desynchronization in a subject in need thereof, comprising confirming the disease or disorder is characterized by electro-mitochondrial desynchronization in the subject and administering an agent that modulates mitochondrial calcium concentration and/or increases mitochondrial calcium channel activity in a tissue of the disease or disorder in the subject. Multichambered cardiac organoids comprising cardiomyocytes and endothelial cells and at least two chambers beating in synchrony are provided. Further provided are methods of using the multichambered cardiac organoid, methods of producing a cardiac organoid. Systems for making measurements within cellular aggregates or tissues and the use of same for testing therapeutic agents is also provided.
    Type: Application
    Filed: March 7, 2024
    Publication date: August 8, 2024
    Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Yaakov NAHMIAS, Mohammad GHOSHEH, Avner EHRLICH
  • Publication number: 20230295575
    Abstract: Provided are methods of generating a metabolically mature human cell selected from the group consisting of a cardiomyocyte, a pancreatic beta cell, and a neuronal cell, using an effective concentration of a conjugated fatty acid and optionally a nonconjugated fatty acid selected from the group consisting of: a monounsaturated omega-9 fatty acid, palmitic acid, linoleic acid (LA) and a short chain fatty acid. Also provided are isolated populations of metabolically mature human cells, and methods and kits using same for selecting a compound for toxicity to the cells.
    Type: Application
    Filed: February 9, 2021
    Publication date: September 21, 2023
    Inventors: Yaakov Nahmias, Avner Ehrlich, Muneef Ayyash
  • Publication number: 20230201226
    Abstract: Methods, compositions and kits for reducing renal tissue toxicity in a subject caused by a kidney damaging agent are provided. The methods comprise administering to the subject: (i) a kidney damaging agent; (ii) a PPARA activator; and (iii) an inhibitor of a cellular pathway selected from the group consisting of C/EBP, PPARG, ER stress, GLUT2 and SGLT1/2; or (i) a kidney damaging agent; (ii) a SGLT2 inhibitor; and (iii) a PPARA activator, a C/EBP inhibitor, a PPARG inhibitor, or an ER stress inhibitor.
    Type: Application
    Filed: February 20, 2023
    Publication date: June 29, 2023
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Yaakov NAHMIAS, Aaron COHEN, Avner EHRLICH
  • Publication number: 20230190745
    Abstract: Methods of treating coronavirus infection, or decreasing the risk of symptomatic infection, by administering a peroxisome proliferator-activated receptor alpha (PPARA) agonist or an inositol-requiring enzyme 1 (IRE1) pathway inhibitor are provided.
    Type: Application
    Filed: October 13, 2022
    Publication date: June 22, 2023
    Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Yaakov NAHMIAS, Avner EHRLICH
  • Publication number: 20220042975
    Abstract: Methods of generating organoids on multi-well plates are provided by depositing a polymeric solution comprising cells under conditions which result in a homogenous population of organoids, which can be used for high throughput analysis for drug screening and for determining treatment regimens of a drug.
    Type: Application
    Filed: August 22, 2021
    Publication date: February 10, 2022
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Yaakov NAHMIAS, Avner EHRLICH, Muneef AYYASH
  • Publication number: 20210379094
    Abstract: A method for reducing renal tissue toxicity in a subject caused by a kidney damaging agent is disclosed. The method comprises administering to the subject: (i) a kidney damaging agent; and (ii) an inhibitor of glucose reabsorption.
    Type: Application
    Filed: August 22, 2021
    Publication date: December 9, 2021
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Yaakov NAHMIAS, Avner EHRLICH, Aaron COHEN
  • Publication number: 20210260311
    Abstract: There are provided herein methods, devices, kits and systems utilizing respiratory mask for delivering pressurized fluid to a subject via inhalation in an efficient manner. The fluid may include gas and/or drug and by utilizing the methods, devices, kits and systems provided, efficient drug delivery to the subject's airways is achieved. The systems, devices, kits and methods further allow inducing insufflation/exsufflation in particular in subjects having impaired suffering from low neuromotor capacity, such as spinal cord injuries (SCI) patients.
    Type: Application
    Filed: June 20, 2019
    Publication date: August 26, 2021
    Inventors: Tomer BATASH, Sigal SHAFRAN-TIKVA, Avner EHRLICH, Yaakov NAHMIAS, Amnon BUXBOIM, Yaron BLINDER, Yoav MINTZ, Elchanan FRIED, Dan ORBACH