Abstract: This disclosure relates to methods of treating cancer using multi-specific binding proteins that bind NKG2D, CD16 and a tumor-associated antigen such as HER2, and pharmaceutical compositions thereof. Also provided are uses of the multi-specific binding protein in combination with an anti-PD-1 therapeutic and/or cytoskeletal disrupting chemotherapeutic agent.

Abstract: Described herein are pharmaceutical formulations comprising multi-specific binding proteins that bind to NKG2D, CD16, and epidermal growth factor receptor (EGFR); and therapeutic uses of the multi-specific binding proteins and pharmaceutical formulations thereof for treating a disease, for example, cancer, in a patient in need thereof.

Abstract: This disclosure relates to methods of treating cancer using multi-specific binding proteins that bind NKG2D, CD16 and a tumor-associated antigen such as HER2. Provided are uses of the multi-specific binding protein in combination with a corticosteroid to reduce the risk of infusion-related reactions. Also provided are uses of the multi-specific binding protein in treating cancer that has low or moderate HER2 expression level. The present disclosure also relates to pharmaceutical formulations comprising the multi-specific binding proteins.

Abstract: The present specification discloses methods for delivering sustainable healthcare to a patient-population suffering from a chronic condition to improved healthcare outcomes. The disclosed methods comprises aligning stakeholders involved in delivering care to the patient-population based on common metrics of success; establishing an advance primary care team to liaison with the patient-population and a community where patient-population resides to facilitate a delivery of care program; identifying the patient-population by assessing one or more individuals suffering from the chronic condition by risk stratification parameters; and implementing a sustainable value-based payment scheme.

Abstract: A method of presenting computer-generated search result information can include receiving a search request from a client computer; identifying a plurality of search results responsive to the search request; ranking the plurality of search results using content in one or more web notebooks; and providing the ranked plurality of search results for presentation in the client computer. Using the content can include determining whether at least one of a title, a heading, clipped content, metadata or a user-annotation in at least one web notebook relates to the search request and, if so, increasing a ranking of at least one search result referenced by the at least one web notebook.

Abstract: A system and machine-implemented method for providing image content corresponding to a business establishment is provided. Several webpages corresponding to a business establishment are received, and one or more webpages are selected from the several webpages, based on the content of each of the several webpages. At least one webpage related to the selected one or more webpages is retrieved. Image content is extracted from the retrieved at least one webpage. At least one annotation is generated for the extracted image content based on at least one characteristic of the extracted image content. The image content is filtered based on the generated at least one annotation for the extracted image content. The filtered image content is provided for display.

Abstract: A method of presenting computer-generated search result information can include receiving a search request from a client computer; identifying a plurality of search results responsive to the search request; ranking the plurality of search results using content in one or more web notebooks; and providing the ranked plurality of search results for presentation in the client computer. Using the content can include determining whether at least one of a title, a heading, clipped content, metadata or a user-annotation in at least one web notebook relates to the search request and, if so, increasing a ranking of at least one search result referenced by the at least one web notebook.

Abstract: Methods, systems, and apparatus, including computer program products, for translation of markup language documents with display replacement. In some implementations, a method includes displaying a markup language document in an original language by rendering an internal representation of the document, sending a data structure containing the texts from the text nodes of the internal representation, as distinct data entities, to a translation service, replacing the texts with translated texts received from the translation service resulting in a translated representation, and displaying a first translation of the document by rendering the translated representation. In some implementations, partial, incremental translation is performed. In some implementations, a method includes receiving a notification that a phrase in a markup language document has been selected, requesting translation of the text of the selected phrase, and then displaying a received translation in a user interface.

Abstract: A method of adding web-based content to a web notebook can include producing multiple search results responsive to a search request; generating in the multiple search results multiple corresponding icons, each of which, when invoked, causes content associated with a corresponding search result in the multiple search results to be placed in a web notebook associated with a user account; and forming a correlation between one of the multiple search results and the web notebook.

Abstract: Methods, systems, and apparatus, including computer program products, for translation of markup language documents with display replacement. In some implementations, a method includes displaying a markup language document in an original language by rendering an internal representation of the document, sending a data structure containing the texts from the text nodes of the internal representation, as distinct data entities, to a translation service, replacing the texts with translated texts received from the translation service resulting in a translated representation, and displaying a first translation of the document by rendering the translated representation. In some implementations, partial, incremental translation is performed. In some implementations, a method includes receiving a notification that a phrase in a markup language document has been selected, requesting translation of the text of the selected phrase, and then displaying a received translation in a user interface.

Abstract: A method of presenting computer-generated search result information can include receiving a search request from a client computer; identifying a plurality of search results responsive to the search request; ranking the plurality of search results using content in one or more web notebooks; and providing the ranked plurality of search results for presentation in the client computer. Using the content can include determining whether at least one of a title, a heading, clipped content, metadata or a user-annotation in at least one web notebook relates to the search request and, if so, increasing a ranking of at least one search result referenced by the at least one web notebook.

Abstract: A method of adding web-based content to a web notebook can include producing multiple search results responsive to a search request; generating in the multiple search results multiple corresponding icons, each of which, when invoked, causes content associated with a corresponding search result in the multiple search results to be placed in a web notebook associated with a user account; and forming a correlation between one of the multiple search results and the web notebook.

Abstract: A user's prior searching and browsing activities are recorded for subsequent use. A user may examine the user's prior searching and browsing activities in a number of different ways, including indications of the user's prior activities related to advertisements. A set of search results may be modified in accordance with the user's historical activities. The user's activities may be examined to identify a set of preferred locations. The user's set of activities may be shared with one or more other users. The set of preferred locations presented to the user may be enhanced to include the preferred locations of one or more other users. A user's browsing activities may be monitored from one or more different client devices or client application. A user's browsing volume may be graphically displayed.