Patents by Inventor Avraham Hochberg

Avraham Hochberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Constructs containing multiple expression cassettes for cancer therapy
    Patent number: 10004813
    Abstract: The present invention relates to the field of cancer treatment, particularly to a novel constructs useful for treating tumors expressing H19 and/or IGF-II. More specifically, the invention provides compositions and methods utilizing a nucleic acid construct enabling expression of a cytotoxic gene product directed by more than one tumor specific promoter.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: June 26, 2018
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Avraham Hochberg, Doron Amit
  • CONSTRUCTS CONTAINING MULTIPLE EXPRESSION CASSETTES FOR CANCER THERAPY
    Publication number: 20160015834
    Abstract: The present invention relates to the field of cancer treatment, particularly to a novel constructs useful for treating tumors expressing H19 and/or IGF-II. More specifically, the invention provides compositions and methods utilizing a nucleic acid construct enabling expression of a cytotoxic gene product directed by more than one tumor specific promoter.
    Type: Application
    Filed: September 30, 2015
    Publication date: January 21, 2016
    Inventors: Avraham HOCHBERG, Doron AMIT
  • Diphtheria toxin first open reading frame operably linked to an H19 promoter and a diphtheria toxin second open reading frame operably linked to an IGF-II promoter as nucleic acid construct
    Patent number: 9173964
    Abstract: The present invention relates to the field of cancer treatment, particularly to a novel constructs useful for treating tumors expressing H19 and/or IGF-II. More specifically, the invention provides compositions and methods utilizing a nucleic acid construct enabling expression of a cytotoxic gene product directed by more than one tumor specific promoter.
    Type: Grant
    Filed: October 23, 2008
    Date of Patent: November 3, 2015
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Avraham Hochberg, Doron Amit
  • Nucleic acid agents for downregulating H19, and methods of using same
    Patent number: 8067574
    Abstract: Isolated oligonucleotides capable of down-regulating H19 mRNA in cancer cells are disclosed, as well as pharmaceutical compositions that include the oligonucleotides and methods of treatment of cancer using them. Methods of treating cancer comprising administering agents capable of downregulating H19 mRNA in combination with an additional anti-cancer treatment are further disclosed.
    Type: Grant
    Filed: January 16, 2008
    Date of Patent: November 29, 2011
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Avraham Hochberg, Imad Matouk
  • Nucleic acid agents for downregulating H19 and methods of using same
    Patent number: 8067573
    Abstract: The present invention provides isolated oligonucleotides capable of down-regulating a level of H19 mRNA in cancer cells. Articles of manufacture comprising agents capable of downregulating H19 mRNA in combination with an additional anti-cancer treatment are disclosed as well as methods of treating cancer by administering same.
    Type: Grant
    Filed: July 6, 2006
    Date of Patent: November 29, 2011
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Avraham Hochberg, Imad Matouk
  • Nucleic acid constructs, pharmaceutical compositions and methods of using same for treating cancer
    Patent number: 8034914
    Abstract: A nucleic acid construct that includes (i) a first nucleic acid sequence encoding TNF alpha; (ii) a second nucleic acid sequence encoding a Diphtheria toxin; and (iii) at least one additional nucleic acid sequence of a cancer specific promoter. The TNF alpha and Diphtheria toxin encoding sequences are under an expression control of the cancer specific promoter. Also provided are construct systems and methods and uses of same.
    Type: Grant
    Filed: September 21, 2006
    Date of Patent: October 11, 2011
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventor: Avraham Hochberg
  • CONSTRUCTS CONTAINING MULTIPLE EXPRESSION CASSETTES FOR CANCER THERAPY
    Publication number: 20100256225
    Abstract: The present invention relates to the field of cancer treatment, particularly to a novel constructs useful for treating tumors expressing H19 and/or IGF-II. More specifically, the invention provides compositions and methods utilizing a nucleic acid construct enabling expression of a cytotoxic gene product directed by more than one tumor specific promoter.
    Type: Application
    Filed: October 23, 2008
    Publication date: October 7, 2010
    Inventors: Avraham Hochberg, Doron Amit
  • NUCLEIC ACID CONSTRUCTS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING SAME FOR TREATING CANCER
    Publication number: 20090221681
    Abstract: A nucleic acid construct that includes (i) a first nucleic acid sequence encoding TNF alpha; (ii) a second nucleic acid sequence encoding a Diphtheria toxin; and (iii) at least one additional nucleic acid sequence of a cancer specific promoter. The TNF alpha and Diphtheria toxin encoding sequences are under an expression control of the cancer specific promoter. Also provided are construct systems and methods and uses of same.
    Type: Application
    Filed: September 21, 2006
    Publication date: September 3, 2009
    Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
    Inventor: Avraham Hochberg
  • NUCLEIC ACID AGENTS FOR DOWNREGULATING H19, AND METHODS OF USING SAME
    Publication number: 20090203121
    Abstract: Isolated oligonucleotides capable of down-regulating H19 mRNA in cancer cells are disclosed, as well as pharmaceutical compositions that include the oligonucleotides and methods of treatment of cancer using them. Methods of treating cancer comprising administering agents capable of downregulating H19 mRNA in combination with an additional anti-cancer treatment are further disclosed.
    Type: Application
    Filed: January 16, 2008
    Publication date: August 13, 2009
    Inventors: Avraham HOCHBERG, Imad Matouk
  • NUCLEIC ACID AGENTS FOR DOWNREGULATING H19 AND METHODS OF USING SAME
    Publication number: 20090143321
    Abstract: The present invention provides isolated oligonucleotides capable of down-regulating a level of H19 mRNA in cancer cells. Articles of manufacture comprising agents capable of downregulating H19 mRNA in combination with an additional anti-cancer treatment are disclosed as well as methods of treating cancer by administering same.
    Type: Application
    Filed: July 6, 2006
    Publication date: June 4, 2009
    Inventors: Avraham Hochberg, Imad Matouk