Patents by Inventor Avram Brickner

Avram Brickner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Composition for sustained release of non-aggregated erythropoietin
    Publication number: 20040224016
    Abstract: A composition, and methods of forming and using said composition, for the sustained release of non-aggregated, biologically active, erythropoietin (EPO). The sustained release composition of this invention comprises a polymeric matrix of a biocompatible polymer and particles of biologically active, aggregation-stabilized EPO, wherein said particles are dispersed within the biocompatible polymer.
    Type: Application
    Filed: October 20, 2003
    Publication date: November 11, 2004
    Inventors: Stephen E. Zale, Paul A. Burke, Howard Bernstein, Avram Brickner
  • Device for the sustained release of aggregation-stabilized, biologically active agent
    Publication number: 20030133979
    Abstract: A device for the sustained release in vivo of a water soluble, biologically active agent wherein the agent is susceptible to aggregation comprising a drug delivery device and aggregation-stabilized, biologically active agent wherein the aggregation-stabilized agent is disposed within the drug delivery device.
    Type: Application
    Filed: October 22, 2002
    Publication date: July 17, 2003
    Applicant: Alkermes Controlled Therapeutics, Inc.
    Inventors: Paul A. Burke, Stephen E. Zale, Mark A. Tracy, OluFunmi Lily Johnson, Howard Bernstein, M. Amin Khan, Avram Brickner, Henry E. Auer
  • Composition for sustained release of non-aggregated erythropoietin
    Publication number: 20030035845
    Abstract: A composition, and methods of forming and using said composition, for the sustained release of non-aggregated, biologically active, erythropoietin (EPO). The sustained release composition of this invention comprises a polymeric matrix of a biocompatible polymer and particles of biologically active, aggregation-stabilized EPO, wherein said particles are dispersed within the biocompatible polymer.
    Type: Application
    Filed: March 7, 2002
    Publication date: February 20, 2003
    Inventors: Stephen E. Zale, Paul A. Burke, Howard Bernstein, Avram Brickner
  • Composition for sustained release of non-aggregated erythropoietin
    Patent number: 5716644
    Abstract: A composition, and methods of forming and using said composition, for the sustained release of non-aggregated, biologically active, erythropoietin (EPO). The sustained release composition of this invention comprises a polymeric matrix of a biocompatible polymer and particles of biologically active, aggregation-stabilized EPO, wherein said particles are dispersed within the biocompatible polymer.The method of the invention for producing a composition for the sustained release of biologically active EPO, includes dissolving a biocompatible polymer in a polymer solvent to form a polymer solution, dispersing particles of biologically active, aggregation-stabilized EPO in the polymer solution, and then solidifying the polymer to form a polymeric matrix containing a dispersion of said EPO particles.The method for using a composition of the invention is a method for providing a therapeutically effective blood level of biologically active, non-aggregated erythropoietin in a subject for a sustained period.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 10, 1998
    Assignee: Alkermes, Inc.
    Inventors: Stephen E. Zale, Paul A. Burke, Howard Bernstein, Avram Brickner
  • Composition for sustained release of non-aggregated erythropoietin
    Patent number: 5674534
    Abstract: A composition, and methods of forming and using said composition, for the sustained release of non-aggregated, biologically active, erythropoietin (EPO). The sustained release composition of this invention comprises a polymeric matrix of a biocompatible polymer and particles of biologically active, aggregation-stabilized EPO, wherein said particles are dispersed within the biocompatible polymer. The method of the invention for producing a composition for the sustained release of biologically active EPO, includes dissolving a biocompatible polymer in a polymer solvent to form a polymer solution, dispersing particles of biologically active, aggregation-stabilized EPO in the polymer solution, and then solidifying the polymer to form a polymeric matrix containing a dispersion of said EPO particles. The method for using a composition of the invention is a method for providing a therapeutically effective blood level of biologically active, non-aggregated erythropoietin in a subject for a sustained period.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 7, 1997
    Assignee: Alkermes, Inc.
    Inventors: Stephen E. Zale, Paul A. Burke, Howard Bernstein, Avram Brickner