Patents by Inventor Awadesh K. Mishra
Awadesh K. Mishra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6974593Abstract: Particles of water insoluble biologically active compounds, particularly water-insoluble drugs, with an average size of 100 nm to about 300 nm, are prepared by dissolving the compound in a solution then spraying the solution into compressed gaz, liquid or supercritical fluid in the presence of appropriate surface modifiers.Type: GrantFiled: June 9, 2003Date of Patent: December 13, 2005Assignees: Jagotec AG, Board of Regents, The University of Texas SystemInventors: Inge B Henriksen, Awadesh K. Mishra, Gary W. Pace, Keith P. Johnston, Simon Mawson
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Patent number: 6726919Abstract: A sterile, injectable homogenized dispersion of micromatrices or microdroplets having a mean diameter from about 50 nm to about 1000 nm comprising about 1% to about 7.5% of propofol, about 1% to about 8% of a propofol-soluble diluent, and about 0.67% to about 5% of a surface stabilizing amphiphilic agent suspended in an aqueous medium containing a synergetic quantity of antimicrobial agent and a tonicity modifying amount of a pharmaceutically acceptable water-soluble hydroxyl-group-containing excipient, wherein the ratio of propofol to diluent is in the range of about 0.25 to about 7.5 while the ratio of propofol to amphiphilic agent is in the range from about 0.4 to about 1.5, and wherein the viscosity of the dispersion is in the range of 1.1 to 8 cps, processes for the formation of the dispersion, and methods of use are disclosed.Type: GrantFiled: June 14, 2001Date of Patent: April 27, 2004Assignee: RTP Pharma, Inc.Inventors: Gary W. Pace, Michael G. Vachon, Awadesh K. Mishra, Robert A. Snow
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Patent number: 6696084Abstract: The present invention relates to a novel spray drying process for the preparation of pharmaceutical compositions containing small particles of phospholipid-stabilized fenofibrate. This invention also relates to spray dried powdered compositions prepared according to this process, and to dosage forms of fenofibrate (capsules, tablets, powders, granules, and dispersions) prepared from these powdered compositions. The powdered compositions and dosage forms are useful in the treatment of dyslipidemia and dyslipoproteinemia and have the advantage that they provide reduced in vivo variability in the bioavailability of fenofibrate active species among fed and fasted patients when administered orally.Type: GrantFiled: April 20, 2001Date of Patent: February 24, 2004Assignee: RTP Pharma Inc.Inventors: Gary W. Pace, Awadesh K. Mishra, Robert A. Snow, Indu Parikh, Pol-Henri W. Guivarc'h
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Publication number: 20040018229Abstract: Particles of water insoluble biologically active compounds, particularly water-insoluble drugs, with an average size of 100 nm to about 300 nm, are prepared by dissolving the compound in a solution then spraying the solution into compressed gaz, liquid or supercritical fluid in the presence of appropriate surface modifiers.Type: ApplicationFiled: June 9, 2003Publication date: January 29, 2004Inventors: Inge B. Henriksen, Awadesh K. Mishra, Gary W. Pace, Keith P. Johnston, Simon Mawson
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Patent number: 6682761Abstract: This invention relates to process for the preparation of small particles containing a poorly water soluble drug comprising (a) mixing at high shear an admixture of a poorly water soluble drug and one or more than one surface active substance in an aqueous carrier in the absence of an organic solvent within a first temperature range at or above the melting point of the poorly water soluble drug to form a heated suspension containing the drug, then (b) homogenizing said heated suspension in a first pressure range and within said first temperature range to form a heated homogenate containing the drug, then (c) cooling said heated homogenate to a second temperature range below the melting temperature of the poorly water soluble drug to form a transiently stable cooled homogenate containing the drug, then (d) applying a particle stabilizing energetic process to said cooled homogenate within a second temperature range below the melting point of the drug and in a second pressure range to form a cooled dispersion ofType: GrantFiled: April 20, 2001Date of Patent: January 27, 2004Assignee: RTP Pharma, Inc.Inventors: Gary W. Pace, Awadesh K. Mishra
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Publication number: 20030194442Abstract: This invention discloses an orally administered pharmaceutical composition comprising microparticles of solid fenofibrate that are stabilized by a phospholipid surface active substance that is present during the preparation of the microparticles, wherein a therapeutically effective amount of the composition provides a quantity of fenofibrate active species to a fasted human patient in need of treatment by fenofibrate that is greater than 80% of the quantity of fenofibrate active species provided by the same amount of the composition when administered to the same patient who has been fed a high fat meal consisting of at least 1000 calories, 50% of which are from fat.Type: ApplicationFiled: May 19, 2003Publication date: October 16, 2003Applicant: SKYEPHARMA CANADA INCInventors: Pol-Henri Guivarch, Gary W. Pace, Robert A. Snow, Awadesh K. Mishra
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Patent number: 6576264Abstract: Particles of water insoluble biologically active compounds, particularly water-insoluble drugs, with an average size of 100 nm to about 300 nm, are prepared by dissolving the compound in a solution then spraying the solution into compressed gaz, liquid or supercritical fluid in the presence of appropriate surface modifiers.Type: GrantFiled: March 12, 1999Date of Patent: June 10, 2003Assignees: SkyePharma Canada Inc., Board of Regents, The University of Texas SystemInventors: Inge B Henriksen, Awadesh K. Mishra, Gary W. Pace, Keith P. Johnston, Simon Mawson
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Publication number: 20020056206Abstract: The present invention relates to a novel spray drying process for the preparation of pharmaceutical compositions containing small particles of phospholipid-stabilized fenofibrate. This invention also relates to spray dried powdered compositions prepared according to this process, and to dosage forms of fenofibrate (capsules, tablets, powders, granules, and dispersions) prepared from these powdered compositions. The powdered compositions and dosage forms are useful in the treatment of dyslipidemia and dyslipoproteinemia and have the advantage that they provide reduced in vivo variability in the bioavailability of fenofibrate active species among fed and fasted patients when administered orally.Type: ApplicationFiled: April 20, 2001Publication date: May 16, 2002Inventors: Gary W. Pace, Awadesh K. Mishra, Robert A. Snow, Indu Parikh, Pol-Henri W. Guivarc'h
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Publication number: 20020058065Abstract: This invention discloses an orally administered pharmaceutical composition comprising microparticles of solid fenofibrate that are stabilized by a phospholipid surface active substance that is present during the preparation of the microparticles, wherein a therapeutically effective amount of the composition provides a quantity of fenofibrate active species to a fasted human patient in need of treatment by fenofibrate that is greater than 80% of the quantity of fenofibrate active species provided by the same amount of the composition when administered to the same patient who has been fed a high fat meal consisting of at least 1000 calories, 50% of which are from fat.Type: ApplicationFiled: April 20, 2001Publication date: May 16, 2002Inventors: Pol-Henri Guivarc'h, Gary W. Pace, Robert A. Snow, Awadesh K. Mishra
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Publication number: 20020022667Abstract: A sterile, injectable homogenized dispersion of micromatrices or microdroplets having a mean diameter from about 50 nm to about 1000 nm comprising about 1% to about 7.5% of propofol, about 1% to about 8% of a propofol-soluble diluent, and about 0.67% to about 5% of a surface stabilizing amphiphilic agent suspended in an aqueous medium containing a synergetic quantity of antimicrobial agent and a tonicity modifying amount of a pharmaceutically acceptable water-soluble hydroxyl-group-containing excipient, wherein the ratio of propofol to diluent is in the range of about 0.25 to about 7.5 while the ratio of propofol to amphiphilic agent is in the range from about 0.4 to about 1.5, and wherein the viscosity of the dispersion is in the range of 1.1 to 8 cps, processes for the formation of the dispersion, and methods of use are disclosed.Type: ApplicationFiled: June 14, 2001Publication date: February 21, 2002Inventors: Gary W. Pace, Michael G. Vachon, Awadesh K. Mishra, Robert A. Snow
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Publication number: 20020012704Abstract: This invention relates to process for the preparation of small particles containing a poorly water soluble drug comprising the steps of (a) mixing at high shear an admixture of a poorly water soluble drug and one or more than one surface active substance in an aqueous carrier in the absence of an organic solvent within a first temperature range at or above the melting point of the poorly water soluble drug to form a heated suspension containing the drug, then (b) homogenizing said heated suspension in a first pressure range and within said first temperature range to form a heated homogenate containing the drug, then (c) cooling said heated homogenate to a second temperature range below the melting temperature of the poorly water soluble drug to form a transiently stable cooled homogenate containing the drug, then (d) applying a particle stabilizing energetic process to said cooled homogenate within a second temperature range below the melting point of the drug and in a second pressure range to form a cooled dType: ApplicationFiled: April 20, 2001Publication date: January 31, 2002Inventors: Gary W. Pace, Awadesh K. Mishra