Abstract: An assistive device for guiding performance of cardiopulmonary resuscitation (CPR) during cardiac arrest (CA), comprising an intelligent device and algorithm that present care givers realtime guidance and feedback on CPR quality using input from multiple invasive and noninvasive biometric monitoring devices. Input is combined and processed using artificial intelligence (AI) techniques to provide performance guidance displayed on a single monitor. Inputs include at least (a) heart rate, (b) end-tidal carbon dioxide—ETCO2, and (c) regional cerebral oxygen saturation—RSO2, which are processed to evaluate effectiveness of ongoing CPR and provide performance indicators in real time directed to increasing CPR effectiveness. Artificial intelligence functions evaluate effectiveness of CPR against standards of care as CPR is performed and provides actionable guidance to improve performance.