Abstract: A process for the preparation of implantable biological tissue, and in particular bioprosthetic heart valves, which are prone to calcification after implantation. The process includes the treatment of tissue with an effective amount of a surfactant to reduce calcification of the implanted tissue.

Abstract: Disclosed is a method of interfacing a ligament substitute within a channel of resected bone with a sleeve of soft biological tissue. The sleeve of tissue has overall external dimension sufficient to extend through at least a portion of the resected bone channel and internal dimensions sufficient to receive a ligament substitute therein.

Abstract: A process for the preparation of implantable biological tissue, and in particular bioprosthetic heart valves, which are prone to calcification after implantation. The process includes the treatment of tissue with an effective amount of a surfactant to reduce calcification of the implanted tissue.

Abstract: A process for treating biological tissue prior to implantation to mitigate the calcification of the tissue following implantation comprises incorporating acetylsalicylic acid into the tissue in an amount effective to reduce calcification of the tissue after it is implanted. In accordance with one embodiment, the process involves convalently binding the acetylsalicylic acid to the tissue via a coupling agent.

Abstract: Residual aldehyde levels in bioprosthetic tissue are reduced by contacting the tissue with a rinsing solution such that aldehyde which has diffused out of the tissue into the rinsing solution comes into contact with, and reacts with, an amine, thus causing further diffusion of aldehyde out of said tissue. The amine may be dissolved in said rinsing solution or may be immobilized on a solid support to which the rinsing solution is periodically or continuously exposed.

Abstract: A process for the preparation of implantable biological tissue wherein elastomeric copolymers are incorporated into the tissue in an amount sufficient to increase the durability of the tissue as well as to reduce calcification of the tissue upon implantation. Mitigaton of calcification is retained when the tissue is subjected to flexing, stretching, or similar motion.

Abstract: A process for selectively incorporating biocompatible polymers in the interstices of implantable biological tissue while leaving the outer surface of the tissue substantially free of bonded polymer. The process involves covalently binding a monomer to the tissue, contacting the tissue with a free-radical initiator, then contacting the tissue with a solution containing a second monomer and a free-radical scavenger, thereby promoting selective polymerization of the second monomer with the portion of covalently-bound first monomer which is located in the interstices of the tissue.

Abstract: A bone grafting material is derived from allogenic or xenogenic bone by a process that includes tanning with glutaraldehyde. The bone may be pulverized, used as a large block, or machined into a precise pre-determined shape, depending on the bone defect to be repaired. Glutaraldehyde tanning of bone yields a stabilized, highly biocompatible, and non-antigenic material which becomes incorporated into host bone when placed adjacent to it.

Abstract: A method of treating a bone fracture which involves interposing a barrier layer of soft biological tissue at the interface of the bone and surrounding tissue.

Abstract: A process for the preparation of implantable biological tissue, and in particular bioprosthetic heart valves, which are prone to calcification after implantation. The process includes treatment of tissue with solutions prior to implantation which have been found effective in reducing calcification of the implanted tissue.

Abstract: A process for the preparation of implantable biological tissue, and in particular bioprosthetic heart valves, which are prone to calcification after implantation. The process includes treatment of tissue with solutions prior to implantation which have been found effective in reducing calcification of the implanted tissue.

Abstract: Prostheses useful for articulating cartilage replacement, and which are attached to host bone without the use of cements, are derived from bone. Allogenic or xenogenic bone segments are machined into the desired shape and differentially demineralized. The completely demineralized portion has a spongy texture similar to natural cartilage, while the non-demineralized portion is a matrix into which adjacent host bone grows, thus anchoring the prosthesis. The prostheses are tanned which renders the material non-antigenic, biocompatible, and stable.

Abstract: Disclosed is a method of using soft biological tissue to interface between a surgically implanted prosthesis, tendon or ligament, and the surface of resected bone to promote the even remodeling of said resected bone.

Abstract: A process for the preparation of implantable biological tissue, and in particular bioprosthetic heart valves, which are prone to calcification after implantation. The process includes the incorporation of biocompatible polymers into the tissue in an amount effective in reducing calcification of the implanted tissue.