Patents by Inventor Axel Brisken

Axel Brisken has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200253583
    Abstract: An implantable ultrasonic vascular sensor for implantation at a fixed location within a vessel, comprising at least one ultrasound transducer, a transducer drive circuit, and means for wirelessly transmitting ultrasound data from the at least one ultrasound transducer.
    Type: Application
    Filed: May 31, 2018
    Publication date: August 13, 2020
    Inventors: Axel Brisken, Jessi Johnson, Douglas S. Sutton, Hanson S. Gifford, III, Mark Deem, Fiachra Sweeney
  • Publication number: 20070232986
    Abstract: An implantable ultrasound transducer device is defined by a plurality of coaxially, longitudinally spaced and acoustically isolated transducer elements, controlled as a phased array to define an exposure annulus within tissue disposed about the transducer array. Operation of the array is controlled to enhance transport of therapeutic substance through the tissue while avoiding thermal damage. The array is configured to enable it to be inserted into the tissue and removed from the tissue through a small surgical or natural opening.
    Type: Application
    Filed: April 28, 2006
    Publication date: October 4, 2007
    Applicant: CytoDome, Inc.
    Inventors: Axel Brisken, Joseph Karratt, Gill Heart
  • Publication number: 20070123939
    Abstract: Methods and apparatus for cardiac pacing, cardioversion and defibrillation rely on delivering ultrasonic or other vibrational energy in combination with electrical energy to the heart, usually after the onset of an arrhythmia. A vibrational transducer and suitable electrical contacts may be combined in a single housing or distributed among various housings, and will usually be implantable so that the vibrational transducer can be directed at a target portion of the heart. Alternatively, external systems comprising the vibrational transducer and electrical contacts are also described.
    Type: Application
    Filed: January 25, 2007
    Publication date: May 31, 2007
    Applicant: EBR System, Inc.
    Inventors: Debra Echt, Axel Brisken, Richard Riley
  • Publication number: 20070078490
    Abstract: Systems including an implantable receiver-stimulator and an external controller-transmitter system are used for leadless acute stimulation of the heart, particularly after heart surgery. Cardiac pacing and arrhythmia control is accomplished with one or more implantable receiver-stimulators and an external system that alternatively includes the use of an external pacemaker. Receiver-stimulators are implanted in the heart during surgery or during an acute interventional procedure and then a triggered for stimulation by using the external system. In one embodiment of these systems, a controller-transmitter is activated by an external pacemaker to time the delivery of acoustic energy transmission through the body to a receiver-stimulator at a target tissue location. The receiver-stimulator converts the acoustic energy to electrical energy for electrical stimulation of the heart tissue.
    Type: Application
    Filed: September 27, 2006
    Publication date: April 5, 2007
    Applicant: EBR Systems, Inc.
    Inventors: MARK COWAN, Debra Echt, Richard Riley, Axel Brisken
  • Publication number: 20070060961
    Abstract: Methods and apparatus for determining an endocardial implantation site for implanting an electrode, such as a leadless stimulation electrode. An embodiment of one method in accordance with the invention includes delivering sufficient electrical energy for initiation of cardiac activation to a plurality of different test locations at the heart of a patient, and determining hemodynamic responses in reaction to that the stimulus delivered to the different test locations. This method further includes identifying an implantation site for implanting the electrode by selecting at least one of the test locations corresponding to a favorable hemodynamic response.
    Type: Application
    Filed: February 10, 2006
    Publication date: March 15, 2007
    Applicant: EBR Systems, Inc.
    Inventors: Debra Echt, Richard Riley, Mark Cowan, Axel Brisken
  • Publication number: 20070055184
    Abstract: The present invention relies on a controller-transmitter device to deliver ultrasound energy into cardiac tissue in order to directly improve cardiac function and/or to energize one or more implanted receiver-stimulator devices that transduce the ultrasound energy to electrical energy to perform excitatory and/or non-excitatory treatments for heart failure. The acoustic energy can be applied as a single burst or as multiple bursts.
    Type: Application
    Filed: August 29, 2006
    Publication date: March 8, 2007
    Applicant: EBR Systems, Inc.
    Inventors: Debra Echt, Richard Riley, Mark Cowan, Axel Brisken
  • Publication number: 20060161061
    Abstract: Systems for pacing the heart include a vibrational transducer which directs energy at the heart, usually at at least a ventricle, to pace the heart and to promote synchronized contraction of the ventricles. Optionally, additional vibrational and/or electrical stimulation may be provided. The vibrational transducers are usually implantable at a location proximate the heart.
    Type: Application
    Filed: March 21, 2006
    Publication date: July 20, 2006
    Applicant: EBR Systems, Inc.
    Inventors: Debra Echt, Axel Brisken, Richard Riley, Mark Cowan
  • Publication number: 20060136005
    Abstract: Receiver-stimulators comprise a nearly isotropic transducer assembly, demodulator circuitry, and at least two tissue contacting electrodes. Use of near isotropic transducers allows the devices to be implanted with less concern regarding the orientation relative to an acoustic energy source. Transducers or transducer elements having relatively small sizes, typically less than ½ the wavelength of the acoustic source, enhance isotropy. The use of single crystal piezoelectric materials enhance sensitivity.
    Type: Application
    Filed: December 21, 2005
    Publication date: June 22, 2006
    Applicant: EBR Systems, Inc.
    Inventors: Axel Brisken, Mark Cowan, Debra Echt, Richard Riley
  • Publication number: 20060136004
    Abstract: Systems including an implantable receiver-stimulator and an implantable controller-transmitter are used for leadless electrical stimulation of body tissues. Cardiac pacing and arrhythmia control is accomplished with one or more implantable receiver-stimulators and an external or implantable controller-transmitter. Systems are implanted by testing external or implantable devices at different tissue sites, observing physiologic and device responses, and selecting sites with preferred performance for implanting the systems. In these systems, a controller-transmitter is activated at a remote tissue location to transmit/deliver acoustic energy through the body to a receiver-stimulator at a target tissue location. The receiver-stimulator converts the acoustic energy to electrical energy for electrical stimulation of the body tissue. The tissue locations(s) can be optimized by moving either or both of the controller-transmitter and the receiver-stimulator to determine the best patient and device responses.
    Type: Application
    Filed: December 21, 2005
    Publication date: June 22, 2006
    Applicant: EBR Systems, Inc.
    Inventors: Mark Cowan, Debra Echt, Richard Riley, Axel Brisken
  • Publication number: 20060058708
    Abstract: The transportation of therapeutic substances through internal tissue is enhanced by surgically implanting an ultrasound transducer in immediate proximity to the target tissue and oriented to direct ultrasound having selected characteristics toward the target tissue. The parameters of frequency, mechanical index, pulses per cycle and pulse repetition frequency are selected within defined ranges to cause molecules to be transported at a rate and over a distance substantially greater than by natural diffusion.
    Type: Application
    Filed: May 31, 2005
    Publication date: March 16, 2006
    Inventors: Gill Heart, Gideon Tolkowsky, Axel Brisken
  • Publication number: 20060058663
    Abstract: The present invention is a device localization system that uses one or more ultrasound reference catheters to establish a fixed three-dimensional coordinate system within a patient's heart using principles of triangulation. The coordinate system is represented graphically in three-dimensions on a video monitor and aids the clinician in guiding other medical devices, which are provided with ultrasound transducers, through the body to locations at which they are needed to perform clinical procedures. In one embodiment of a system according to the present invention, the system is used in the heart to help the physician guide mapping catheters for measuring electrical activity, and ablation catheters for ablating selected regions of cardiac tissue, to desired locations within the heart.
    Type: Application
    Filed: September 9, 2005
    Publication date: March 16, 2006
    Applicant: SCIMED LIFE SYSTEMS, INC.
    Inventors: N. Willis, Axel Brisken, Jinglin Zeng, Marsha Hurd
  • Patent number: 6970733
    Abstract: The present invention is a device localization system that uses one or more ultrasound reference catheters to establish a fixed three-dimensional coordinate system within a patient's heart using principles of triangulation. The coordinate system is represented graphically in three-dimensions on a video monitor and aids the clinician in guiding other medical devices, which are provided with ultrasound transducers, through the body to locations at which they are needed to perform clinical procedures. In one embodiment of a system according to the present invention, the system is used in the heart to help the physician guide mapping catheters for measuring electrical activity, and ablation catheters for ablating selected regions of cardiac tissue, to desired locations within the heart.
    Type: Grant
    Filed: October 21, 2002
    Date of Patent: November 29, 2005
    Assignee: SciMed Life Systems, Inc.
    Inventors: N. Parker Willis, Axel Brisken, Jinglin Zeng, Marsha Hurd
  • Publication number: 20050131468
    Abstract: Methods and systems for pacing the heart include a vibrational transducer which directs energy at the heart, usually including at least a ventricle, to pace the heart to promote synchronized contraction of the ventricles. Optionally, additional vibrational and/or electrical stimulation may be provided.
    Type: Application
    Filed: June 15, 2004
    Publication date: June 16, 2005
    Applicant: EBR Systems, Inc.
    Inventors: Debra Echt, Axel Brisken, Richard Riley, Mark Cowan
  • Publication number: 20050070962
    Abstract: Methods and apparatus for treating heart failure rely on delivering ultrasonic or other vibrational energy to the heart. The energy may be delivered acutely or chronically, in response to detected cardiac events, in response to manual actuation and/or in response to operation of an implantable defibrillator. The vibrational transducer is implanted so that the vibrational energy can be directed toward at least a portion of the heart in order to increase contractility, vasodilation, tissue perfusion, and/or cardiac output.
    Type: Application
    Filed: June 15, 2004
    Publication date: March 31, 2005
    Applicant: EBR Systems, Inc.
    Inventors: Debra Echt, Axel Brisken, Richard Riley, Mark Cowan
  • Publication number: 20050043762
    Abstract: Methods and apparatus for cardiac pacing, cardioversion and defibrillation rely on delivering ultrasonic or other vibrational energy in combination with electrical energy to the heart, usually after the onset of an arrhythmia. A vibrational transducer and suitable electrical contacts may be combined in a single housing or distributed among various housings, and will usually be implantable so that the vibrational transducer can be directed at a target portion of the heart. Alternatively, external systems comprising the vibrational transducer and electrical contacts are also described.
    Type: Application
    Filed: June 15, 2004
    Publication date: February 24, 2005
    Applicant: EBR Systems, Inc.
    Inventors: Debra Echt, Axel Brisken, Richard Riley
  • Publication number: 20040267234
    Abstract: Implantable ultrasonic transducer devices and methods are provided to enhance local delivery and tissue uptake of therapeutic substances using phonophoresis. The transducers are adopted to be implanted immediately adjacent or within the target tissue to which the therapeutic substances also are delivered.
    Type: Application
    Filed: December 24, 2003
    Publication date: December 30, 2004
    Inventors: Gill Heart, Gideon Tolkowsky, Axel Brisken, Joe Karratt
  • Publication number: 20030036696
    Abstract: The present invention is a device localization system that uses one or more ultrasound reference catheters to establish a fixed three-dimensional coordinate system within a patient's heart using principles of triangulation. The coordinate system is represented graphically in three-dimensions on a video monitor and aids the clinician in guiding other medical devices, which are provided with ultrasound transducers, through the body to locations at which they are needed to perform clinical procedures. In one embodiment of a system according to the present invention, the system is used in the heart to help the physician guide mapping catheters for measuring electrical activity, and ablation catheters for ablating selected regions of cardiac tissue, to desired locations within the heart.
    Type: Application
    Filed: October 21, 2002
    Publication date: February 20, 2003
    Applicant: Cardiac Pathways Corporation
    Inventors: N. Parker Willis, Axel Brisken, Jinglin Zeng, Marsha Hurd
  • Publication number: 20020188243
    Abstract: A catheter comprises a catheter body having an oscillating driver, an interface surface mechanically coupled to the driver, and an inflatable balloon disposed near the interface surface. The balloon may be an angioplasty balloon, in which case the interface surface will deliver ultrasonic or other vibratory energy into a blood vessel as part of an angioplasty or related procedure. Alternatively, the catheter may comprise a pair of axially spaced-apart isolation balloons, in which case the interface surface can deliver ultrasonic or other vibratory energy into a treatment region defined between said balloons. The energy can thus act to mix or enhance penetration of a treatment held between said balloons in performing a vascular treatment procedure.
    Type: Application
    Filed: July 31, 2002
    Publication date: December 12, 2002
    Applicant: PHARMASONICS, INC.
    Inventors: Axel Brisken, Vartan Ghazarossian
  • Patent number: 6490474
    Abstract: The present invention is a device localization system that uses one or more ultrasound reference catheters to establish a fixed three-dimensional coordinate system within a patient's heart using principles of triangulation. The coordinate system is represented graphically in three-dimensions on a video monitor and aids the clinician in guiding other medical devices, which are provided with ultrasound transducers, through the body to locations at which they are needed to perform clinical procedures. In one embodiment of a system according to the present invention, the system is used in the heart to help the physician guide mapping catheters for measuring electrical activity, and ablation catheters for ablating selected regions of cardiac tissue, to desired locations within the heart.
    Type: Grant
    Filed: August 1, 1997
    Date of Patent: December 3, 2002
    Assignee: Cardiac Pathways Corporation
    Inventors: N. Parker Willis, Axel Brisken, Jinglin Zeng, Marsha Hurd
  • Patent number: 6464660
    Abstract: A catheter comprises a catheter body having an oscillating driver, an interface surface mechanically coupled to the driver, and an inflatable balloon disposed near the interface surface. The balloon may be an angioplasty balloon, in which case the interface surface will deliver ultrasonic or other vibratory energy into a blood vessel as part of an angioplasty or related procedure. Alternatively, the catheter may comprise a pair of axially spaced-apart isolation balloons, in which case the interface surface can deliver ultrasonic or other vibratory energy into a treatment region defined between said balloons. The energy can thus act to mix or enhance penetration of a treatment held between said balloons in performing a vascular treatment procedure.
    Type: Grant
    Filed: March 14, 2001
    Date of Patent: October 15, 2002
    Assignee: Pharmasonics, Inc.
    Inventors: Axel Brisken, Vartan Ghazarossian