Abstract: Nucleic acid transfection of vascular smooth muscle cells is enhanced by the application of vibrational energy to the cells. By applying vibrational energy at frequency in the range from 1 kHz to 10 MHz and at an intensity in the range from 0.01 W/cm2 to 100 W/cm2, significant enhancement of the uptake of nucleic acids into vascular smooth muscle cells can be achieved.

Abstract: A method for inhibiting hyperplasia at an anastomotic junction of a vascular fistula or vascular graft comprises exposing the anastomotic junction to vibrational energy at a mechanical index and for a time sufficient to inhibit hyperplasia. Kits are described comprising the catheter or a probe suitable for performing the methods together with instructions for use setting forth the methods. The methods and kits are particularly suitable for treating anastomotic junctions formed to provide vascular access for hemodialysis, hemofiltration, and the like. The methods and kits are also suitable for treating other vascular grafts, such as those formed during cardiac bypass graft surgery, vascular repair, and the like.

Abstract: A method for inhibiting hyperplasia at an anastomotic junction of a vascular fistula or vascular graft comprises exposing the anastomotic junction to vibrational energy at a mechanical index and for a time sufficient to inhibit hyperplasia. Kits are described comprising the catheter or a probe suitable for performing the methods together with instructions for use setting forth the methods. The methods and kits are particularly suitable for treating anastomotic junctions formed to provide vascular access for hemodialysis, hemofiltration, and the like. The methods and kits are also suitable for treating other vascular grafts, such as those formed during cardiac bypass graft surgery, vascular repair, and the like.

Abstract: Nucleic acid transfection of vascular smooth muscle cells is enhanced by the application of vibrational energy to the cells. By applying vibrational energy at frequency in the range from 1 kHz to 10 MHz and at an intensity in the range from 0.01 W/cm2 to 100 W/cm2, significant enhancement of the uptake of nucleic acids into vascular smooth muscle cells can be achieved.

Abstract: Methods for delivering vibrational energy to subcutaneous tissue sites comprise externally generating acoustic energy and directing the external energy to an implanted structure which is capable of resonating at a pre-selected frequency. The vibration of the implanted structure, in turn, will reradiate heat and mechanical energy into tissue surrounding the structure. In one example, the implanted structure is a stent and the vibrational energy is intended to inhibit hyperplasia in a blood vessel in which the stent is implanted.

Abstract: A method of treating a target region in a body lumen, said method comprising: directing a uniform dose of ultrasonic energy from an interior of the lumen radially outward over a treatment length of the lumen, wherein the dosage of ultrasonic energy received at any one point along the length varies by no more than plus or minus 6 decibels from that received at any other point along the length.

Abstract: A method of treating a target region in a body lumen, said method comprising: directing a uniform dose of ultrasonic energy from an interior of the lumen radially outward over a treatment length of the lumen, wherein the dosage of ultrasonic energy received at any one point along the length varies by no more than plus or minus 6 decibels from that received at any other point along the length.

Abstract: A catheter comprises a catheter body having an oscillating driver, an interface surface mechanically coupled to the driver, and an inflatable balloon disposed near the interface surface. The balloon may be an angioplasty balloon, in which case the interface surface will deliver ultrasonic or other vibratory energy into a blood vessel as part of an angioplasty or related procedure. Alternatively, the catheter may comprise a pair of axially spaced-apart isolation balloons, in which case the interface surface can deliver ultrasonic or other vibratory energy into a treatment region defined between said balloons. The energy can thus act to mix or enhance penetration of a treatment held between said balloons in performing a vascular treatment procedure.

Abstract: A catheter including an elongated body member, an ultrasound transducer located on the elongated body member, and dampening means for forming an ultrasound dampening region adjacent to a portion of the ultrasound transducer, is disclosed. The ultrasound transducer is configured to transmit or receive an ultrasound signal. The ultrasound dampening region is configured to improve uniformity of said ultrasound signal in three-dimensional space. Preferably, the dampening means includes air or a material containing air.

Abstract: Nucleic acid transfection of vascular smooth muscle cells is enhanced by the application of vibrational energy to the cells. By applying vibrational energy at frequency in the range from 1 kHz to 10 MHz and at an intensity in the range from 0.01 W/cm2 to 100 W/cm2, significant enhancement of the uptake of nucleic acids into vascular smooth muscle cells can be achieved.

Abstract: A catheter comprises a catheter body having a vibrational transducer disposed at or near its distal end. The vibrational transducer comprises a plurality of oscillators such as bending plate oscillators or other conventional oscillators each having a vibrational surface capable of imparting pressure waves. The plurality of oscillators may be disposed at a distal end of the catheter body or may alternatively be disposed within the catheter body. The catheter may further comprise lumens for drug delivery, balloons for encircling the transducer structures, or the like. The catheters are useful in a variety of lumenal therapeutic procedures, including drug delivery, stenotic disruption within blood vessel, and the like.

Abstract: An energy transmitting catheter comprises a catheter body (16) having a vibrating assembly at its distal end. The vibrating assembly comprises a magnetostriction driver (40) which is mechanically coupled to an interface member (46) on the catheter for radiating energy into an environment surrounding the distal end of the catheter. Usually, the vibrating assembly further includes a tail mass (44), an interface member (46), and a spring element (48) which together and in combination with the magnetostriction driver define a resonant assembly for amplification of the displacement of the interface surface provided by the magnetostriction driver. The catheter is useful for treating luminal conditions, such as vascular clot and plaque. Optionally, a therapeutic agent may be delivered through the catheter before, after, or simultaneously with the application of vibratory energy.

Abstract: Post-interventional neointimal hyperplasia in arteries is treated by the application of ultrasonic energy. Usually, an intravascular catheter having an interface surface is positioned at a target site in the artery which has previously been treated. The interface surface is vibrationally excited to apply energy to the arterial wall in a manner which inhibits smooth muscle cell proliferation in the neointimal layer.

Abstract: A device for diagnosing and treating hearing disorders including a supersonic transducer which has a resonance frequency in the supersonic range. The transducer includes a piezoelectric ceramic tube which is compressed between a head mass and an inertial mass. A tensioning rod extends between the masses and is threadedly engaged with a nut which tensions the rod to adjust the compression on the ceramic tube. A tuning circuit can be used to increase the band width at resonance.

Abstract: A catheter comprises a catheter body having a bending plate transducer disposed at or near its distal end. The bending plate transducer is typically a unimorph, bimorph, or other conventional vibratory transducer capable of imparting pressure waves in a direction generally normal to the plane of the transducer. The bending plate transducers may be disposed at a distal end of the catheter body, for example, as a cantilever beam, or may alternately be disposed within the catheter body. The catheters may further comprise lumens for drug delivery, balloons for encircling the transducer structures, or the like. The catheters are useful in a variety of lumenal therapeutic procedures, including drug delivery, stenotic disruption within blood vessel, and the like.

Abstract: A catheter comprises a catheter body having an oscillating driver, an interface surface mechanically coupled to the driver, and an inflatable balloon disposed near the interface surface. The balloon may be an angioplasty balloon, in which case the interface surface will deliver ultrasonic or other vibratory energy into a blood vessel as part of an angioplasty or related procedure. Alternatively, the catheter may comprise a pair of axially spaced-apart isolation balloons, in which case the interface surface can deliver ultrasonic or other vibratory energy into a treatment region defined between said balloons. The energy can thus act to mix or enhance penetration of a treatment held between said balloons in performing a vascular treatment procedure.

Abstract: A catheter for ultrasonic imaging has a transducer fixed to a cutter. The transducer is moved longitudinally within an artery while in a fixed radial position. Ultrasonic reflections are received and processed to display a planer or rectangular field of view image area of the artery. Other axial planes of the artery can be imaged by radially turning the transducer to a different angular orientation within the artery and then longitudinally moving the transducer to obtain an image of another planer field of view.

Abstract: An ultrasonic catheter comprises a catheter body having an interface surface which extends at least partially over a circumferential portion of the catheter body. The interface surface is coupled to an oscillating driver so that axial and/or radial oscillations are radiated into a fluid environment surrounding the catheter body. Optionally, the catheter may be provided with a fluid infusion lumen and/or inflatable balloons on either side of the interface surface in order to deliver treatment fluid within a specific or isolated region in a body lumen.

Abstract: An energy-transmitting catheter comprises a catheter body having a vibrating assembly at its distal end. The vibrating assembly comprises a magnetostrictive driver which is mechanically coupled to an interface member on the catheter for radiating energy into an environment surrounding the distal end of the catheter. Usually, the vibrating assembly further includes a tail mass, an interface member, and a spring element which together and in combination with the magnetostrictive driver define a resonant assembly for amplification of the displacement of the interface surface provided by the magnetostrictive driver. The catheter is useful for treating luminal conditions, such as vascular clot and plaque. Optionally, a therapeutic agent may be delivered through the catheter before, after, or simultaneously with the application of vibratory energy.

Abstract: An ultrasonic catheter comprises a catheter body having a resonantly vibrating assembly at its distal end. The resonantly vibrating assembly comprises a tail mass, an interface member, and a spring element which connects the tail mass to the interface member. An interface surface is formed on the interface member and is forwardly disposed at the distal end of the catheter. A longitudinally oscillating driver is disposed between the tail mass and the interface member, and the catheter can be connected to a suitable power supply to induce oscillations in the driver. The driver is typically a piezoelectric device, such as a tubular piezoelectric transducer or a piezoelectric stack. The characteristics of the interface member, spring element, and longitudinally oscillating driver are selected so that the interface member may be resonantly vibrated at an ultrasonic frequency. The catheter is useful for treating luminal conditions, such as vascular clot and plaque.