Abstract: Various embodiments of drug delivery devices and methods of assembling such devices are provided. In one embodiment, a drug delivery device for dispensing medicament comprises a medicament cartridge, wherein the cartridge comprises (i) a distal end, (ii) a proximal end that is opposite the distal end along a body axis of the cartridge, and (iii) a movable piston arranged substantially at the proximate end of the cartridge. The drug delivery device further comprises a piston rod having a distal end for axially moving the piston in the distal direction during dispensing of a set dose of medicament, wherein a relative axial distance between the distal end of the piston rod and a proximal face of the piston is set during assembly of the drug delivery system. The relative axial position between may be set such that the piston rod and the proximal face of the piston abut each other.

Abstract: Various embodiments of drug delivery devices and methods of assembling such devices are provided. In one embodiment, a drug delivery device for dispensing medicament comprises a medicament cartridge, wherein the cartridge comprises (i) a distal end, (ii) a proximal end that is opposite the distal end along a body axis of the cartridge, and (iii) a movable piston arranged substantially at the proximate end of the cartridge. The drug delivery device further comprises a piston rod having a distal end for axially moving the piston in the distal direction during dispensing of a set dose of medicament, wherein a relative axial distance between the distal end of the piston rod and a proximal face of the piston is set during assembly of the drug delivery system. The relative axial position between may be set such that the piston rod and the proximal face of the piston abut each other.

Abstract: The present invention relates to a separating device and to a respective method for separating an item from a stack (12) of items (14), the separating device comprising: —a carrier unit (20; 40; 50) having a support surface (24; 44; 54) to support numerous items (14) stacked on top of each other in an axial direction (z), and having at least a first discharge outlet (25; 45; 55) for a pressurized fluid to at least partially raise the stack (12) of items (14) from an initial position into an elevated position relative to the support surface (24; 44; 54) and to keep at least several items (14) of the stack (12) in the elevated position, —a gripping unit (30; 60) having at least one suction nozzle (38; 68) to grip the uppermost item (14) when the stack (12) is in the elevated position, and—wherein the carrier unit (20; 40; 50) and the gripping unit (30; 60) are displaceable relative to each other at least in the axial direction (z).

Abstract: A drug delivery device for administering a predefined dose of a medicament comprising a housing is presented where the housing includes a body to accommodate a drive mechanism, a cartridge holder to accommodate a cartridge having a piston slidably disposed therein in an axial direction (z), and an interconnection between cartridge holder and body. The interconnection has, at least one displaceable or resiliently deformable latch element to mate with a corresponding bearing, and the latch element is displaceable or deformable in a direction (z, w) extending substantially parallel to a circumferential side wall of the body or cartridge holder.

Abstract: The present invention relates to an arrangement for use in a drug delivery device comprising a cartridge holder, the cartridge holder comprising an opening at its distal end, a needle holder and one or more intermediate elements, wherein when the needle holder is mounted to the cartridge holder and the one or more intermediate elements are arranged in the opening of the cartridge holder whereby the size of the free space within the opening is reduced. Furthermore, it relates to a drug delivery device which is comprising such an arrangement and to a method for stabilizing a septum located at the distal end of a medicament cartridge.

Abstract: The present invention relates to a separating device and to a respective method for separating an item from a stack (12) of items (14), the separating device comprising: —a carrier unit (20; 40; 50) having a support surface (24; 44; 54) to support numerous items (14) stacked on top of each other in an axial direction (z), and having at least a first discharge outlet (25; 45; 55) for a pressurized fluid to at least partially raise the stack (12) of items (14) from an initial position into an elevated position relative to the support surface (24; 44; 54) and to keep at least several items (14) of the stack (12) in the elevated position, —a gripping unit (30; 60) having at least one suction nozzle (38; 68) to grip the uppermost item (14) when the stack (12) is in the elevated position, and—wherein the carrier unit (20; 40; 50) and the gripping unit (30; 60) are displaceable relative to each other at least in the axial direction (z).

Abstract: A drive mechanism for a drug delivery device is presented having a housing, an axially displaceable piston rod to act on a piston of a cartridge containing a medicinal product to be dispensed, a drive member threadedly engaged with the piston rod and being slidably disposed relative to the housing between a distal stop position and a proximal stop position. During the setting of a dose the drive member is rotatable with respect to the housing and a dose dial member is operably engaged with the drive member by means of a reduction gear, wherein the drive member at its proximal end section comprises a radially extending receptacle adapted to receive the reduction gear.

Abstract: A housing component of a drug delivery device to accommodate a drive mechanism, wherein the drive mechanism is operable to interact with a piston of a cartridge containing a medicinal product to be dispensed by the drug delivery device. The housing component comprises at least one radially inwardly extending flange portion to be operably engaged with a piston rod of the drive mechanism, wherein that the flange portion is at least partially structurally strengthened.

Abstract: A drug delivery device for dispensing of a dose of a medicinal product comprises a housing having a proximal end and a distal end, a container of medicinal product having a piston retained within, and a push-pull element, where the push-pull element is displaceable in proximal direction for setting of a dose and is displaceable in distal direction for dispensing of a dose. The drug delivery device may further include a piston rod coupled with the housing and with the push-pull element and coupling elements for converting a proximal displacement of the push-pull element into a rotational movement of the piston rod and for converting a distal displacement of the push-pull element into an axial movement of the piston rod with respect to the housing.

Abstract: The present invention relates to a drug delivery device for administering a predefined dose of a medicament comprising of housing. The housing comprising of a body to accommodate a drive mechanism, a cartridge holder to accommodate a cartridge having a piston slidably disposed therein in an axial direction (z), and an interconnection between cartridge holder and body, said interconnection having at least one displaceable or resiliently deformable latch element to mate with a corresponding bearing, wherein the latch element is displaceable or deformable in a direction (z, w) extending substantially parallel to a circumferential side wall of the body or cartridge holder.

Abstract: Various embodiments of drug delivery devices and methods of assembling such devices are provided. In one embodiment, a drug delivery device for dispensing medicament comprises a medicament cartridge, wherein the cartridge comprises (i) a distal end, (ii) a proximal end that is opposite the distal end along a body axis of the cartridge, and (iii) a movable piston arranged substantially at the proximate end of the cartridge. The drug delivery device further comprises a piston rod having a distal end for axially moving the piston in the distal direction during dispensing of a set dose of medicament, wherein a relative axial distance between the distal end of the piston rod and a proximal face of the piston is set during assembly of the drug delivery system. The relative axial position between may be set such that the piston rod and the proximal face of the piston abut each other.

Abstract: Various embodiments of drug delivery devices and methods of assembling such devices are provided. In one embodiment, a drug delivery device for dispensing medicament comprises a medicament cartridge, wherein the cartridge comprises (i) a distal end, (ii) a proximal end that is opposite the distal end along a body axis of the cartridge, and (iii) a movable piston arranged substantially at the proximate end of the cartridge. The drug delivery device further comprises a piston rod having a distal end for axially moving the piston in the distal direction during dispensing of a set dose of medicament, wherein a relative axial distance between the distal end of the piston rod and a proximal face of the piston is set during assembly of the drug delivery system. The relative axial position between may be set such that the piston rod and the proximal face of the piston abut each other.

Abstract: The present invention relates to an arrangement for use in a drug delivery device comprising a cartridge holder, the cartridge holder comprising an opening at its distal end, a needle holder and one or more intermediate elements, wherein when the needle holder is mounted to the cartridge holder and the one or more intermediate elements are arranged in the opening of the cartridge holder whereby the size of the free space within the opening is reduced. Furthermore, it relates to a drug delivery device which is comprising such an arrangement and to a method for stabilizing a septum located at the distal end of a medicament cartridge.

Abstract: The present invention relates to a drive mechanism for a drug delivery device, comprising: a housing, an axially displaceable piston rod to act on a piston of a cartridge containing a medicinal product to be dispensed, a drive member threadedly engaged with the piston rod and being slidably disposed relative to the housing between a distal stop position and a proximal stop position, wherein for setting of a dose, the drive member is rotatable with respect to the housing (14), a dose dial member operably engaged with the drive member by means of a reduction gear, wherein the drive member at its proximal end section comprises a radially extending receptacle adapted to receive the reduction gear.

Abstract: The present invention relates to a housing component of a drug delivery device (10) to accommodate a drive mechanism (11), wherein the drive mechanism (11) is operable to interact with a piston (20) of a cartridge(16) containing a medicinal product to be dispensed by the drug delivery device. The housing component comprises at least one radially inwardly extending flange portion (16) to be operably engaged with a piston rod (24) of the drive mechanism (11), characterized in that the flange portion (16) is at least partially structurally strengthened.

Abstract: The invention provides a drug delivery device for dispensing of a dose of a medicinal product, comprising: a housing having a proximal end and a distal end, a container comprising the medicinal product, a piston being retained in the container, a push-pull element, wherein the push-pull element is displaceable in proximal direction for setting of a dose and wherein the push-pull element is displaceable in distal direction for dispensing of a dose, a piston rod being coupled with the housing and having a distal end to interact with the container's piston, the piston rod being further coupled with the push-pull element, coupling elements for converting a proximal displacement of the push-pull element into a rotational movement of the piston rod and for converting a distal displacement of the push-pull element into an axial movement of the piston rod with respect to the housing.

Abstract: The present invention relates to a drive mechanism for a drug delivery device as well as to a drug delivery device for dispensing of a dose of a medicinal product, wherein the drive mechanism comprises: a holder for a product-containing cartridge, the cartridge having a piston slidably arranged therein in an axial direction, a piston rod to be operably engaged with the cartridge's piston for dispensing of a dose of the medicinal product, at least one adjusting member slidably arranged in axial direction relative to the piston and/or relative to the piston rod for eliminating axial clearance between the piston and the piston rod, an interlock means adapted to interact with the adjusting member for mutually locking in position the piston and the piston rod irrespective of the relative distance between piston and piston rod.

Abstract: Various embodiments of drug delivery devices and methods of assembling such devices are provided. In one embodiment, a drug delivery device for dispensing medicament comprises a medicament cartridge, wherein the cartridge comprises (i) a distal end, (ii) a proximal end that is opposite the distal end along a body axis of the cartridge, and (iii) a movable piston arranged substantially at the proximate end of the cartridge. The drug delivery device further comprises a piston rod having a distal end for axially moving the piston in the distal direction during dispensing of a set dose of medicament, wherein a relative axial distance between the distal end of the piston rod and a proximal face of the piston is set during assembly of the drug delivery system. The relative axial position between may be set such that the piston rod and the proximal face of the piston abut each other.