Patents by Inventor Axel Hanauske

Axel Hanauske has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of inhibiting viral replication in eukaryotic cells and of inducing apoptosis of virally-infected cells
    Patent number: 5849587
    Abstract: The present invention is directed to methods which employ inhibition of the post-translational hypusine formation in the intracelluar protein eIF-5A, for the purpose of suppressing infections by viruses that parasitize eIF-5A so as to promote their own replication. Intentional inhibition of the post-translational formation of hypusine in infected host cells with compounds generically termed `hypusine inhibitors` not only selectively suppresses the production of viral proteins and of infectious viral particles, but also causes, particularly after hypusine inhibitor withdrawal, apoptosis in such virally-infected cells.
    Type: Grant
    Filed: June 9, 1995
    Date of Patent: December 15, 1998
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Hartmut M. Hanauske-Abel, Robert Walter Grady, Axel Hanauske, Linda Andrus, Paul Szabo