Patents by Inventor Axel Hoffmann
Axel Hoffmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11458789Abstract: A fork leg for rotating a wheel of a motor vehicle is provided with a fastening flange for the coaxial, torque-proof fastening of a steering rod, an extension region protruding from the fastening flange substantially perpendicularly to the steering axis for bridging a lateral distance to the wheel, a coupling point for the articulated connection of a rocker which is connected to the wheel and a connection piece which is connected integrally to the extension region and to the coupling point, wherein the connection piece is shaped to accommodate a large steering angle.Type: GrantFiled: April 4, 2019Date of Patent: October 4, 2022Assignee: Schaeffler Technologies AG & Co. KGInventors: Benjamin Wuebbolt-Gorbatenko, Simon Mersmann, Christian Harkort, Andreas Wöllner, Axel Hoffmann
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Publication number: 20210252928Abstract: A fork leg for rotating a wheel of a motor vehicle is provided with a fastening flange for the coaxial, torque-proof fastening of a steering rod, an extension region protruding from the fastening flange substantially perpendicularly to the steering axis for bridging a lateral distance to the wheel, a coupling point for the articulated connection of a rocker which is connected to the wheel and a connection piece which is connected integrally to the extension region and to the coupling point, wherein the connection piece is shaped to accommodate a large steering angle.Type: ApplicationFiled: April 4, 2019Publication date: August 19, 2021Applicant: Schaeffler Technologies AG & Co. KGInventors: Benjamin Wuebbolt-Gorbatenko, Simon Mersmann, Christian Harkort, Andreas Wöllner, Axel Hoffmann
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Publication number: 20210023899Abstract: A wheel module for a motor vehicle is provided with a wheel, a steering rod which can be rotatably mounted on a supporting frame of the motor vehicle for transmitting a steering motion to the wheel, a wishbone connected to the steering rod for forming an articulation point radially offset relative to the wheel, a rocker articulated to the articulation point of the wishbone and to the wheel, and a shock absorber connected to the rocker and the wishbone for damping vibration of a relative movement of the wheel. The shock absorber, in particular including a chassis spring, is arranged to be axially offset in the axial direction of the wheel relative to the wheel. With the shock absorber connected to the wheel and the wishbone and arranged next to the wheel, a large steering angle for a motor vehicle is possible with a small installation space.Type: ApplicationFiled: March 26, 2019Publication date: January 28, 2021Applicant: Schaeffler Technologies AG & Co. KGInventors: Benjamin Wuebbolt-Gorbatenko, Simon Mersmann, Andreas Wöllner, Axel Hoffmann, Christian Harkort, Manfred Kraus
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Publication number: 20190263913Abstract: The invention is directed to the treatment of prostate cancer by means of antibodies. Above all, the invention relates to the administration of an anti-alpha-v integrin (receptor) antibody to patients suffering from prostate cancer, especially castration-resistant prostate cancer (CRPC), optionally accompanied by lymph node and bone tissue metastases (mCRPC). In particular, the invention relates to the therapy of said patients by means of the anti-angiogenic antibody DI17E6 and structural mutants thereof.Type: ApplicationFiled: January 25, 2019Publication date: August 29, 2019Inventors: Axel Hoffmann, Heinrich Lannert, Klaus Brischwein, Frederic Christian Pipp, Juergen Reindl, Karin Groll, Michael Zuehlsdorf, Otmar Pfaff, Sabine Raab, Ulrike Dau, Benoit Destenaves
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Patent number: 10217898Abstract: A semiconductor device comprises a layer sequence formed by a plurality of polar single crystalline semiconductor material layers that each have a crystal axis pointing in a direction of crystalline polarity and a stacking direction of the layer sequence. A core layer sequence is formed by an active region made of an active layer stack or a plurality of repetitions of the active layer stack. The active layer stack has an active layer having a first material composition associated with a first band gap energy, and carrier-confinement layers embedding the active layer on at least two opposite sides thereof, having a second material composition associated with a second band gap energy larger than the first band gap energy. A pair of polarization guard layers is arranged adjacent to the active region and embedding the active region on opposite sides thereof. Both polarization guard layers have the first material composition.Type: GrantFiled: September 9, 2016Date of Patent: February 26, 2019Assignee: TECHNISCHE UNIVERSITÄT BERLINInventors: Gerald Pahn, Gordon Callsen, Axel Hoffmann
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Publication number: 20180261718Abstract: A semiconductor device comprises a layer sequence formed by a plurality of polar single crystalline semiconductor material layers that each have a crystal axis pointing in a direction of crystalline polarity and a stacking direction of the layer sequence. A core layer sequence is formed by an active region made of an active layer stack or a plurality of repetitions of the active layer stack. The active layer stack has an active layer having a first material composition associated with a first band gap energy, and carrier-confinement layers embedding the active layer on at least two opposite sides thereof, having a second material composition associated with a second band gap energy larger than the first band gap energy. A pair of polarization guard layers is arranged adjacent to the active region and embedding the active region on opposite sides thereof. Both polarization guard layers have the first material composition.Type: ApplicationFiled: September 9, 2016Publication date: September 13, 2018Inventors: Gerald Pahn, Gordon Callsen, Axel Hoffmann
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Publication number: 20180130927Abstract: The invention relates to a component having a transparent conductive nitride layer, characterized by a layer in the AlGaInN system and a doping with a flat donor above a concentration of 5×1019 cm?3.Type: ApplicationFiled: June 4, 2016Publication date: May 10, 2018Inventors: Armin DADGAR, Axel HOFFMANN, Christian NENSTIEL, André STRITTMATTER
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Publication number: 20170218070Abstract: The invention is directed to the treatment of prostate cancer by means of antibodies. Above all, the invention relates to the administration of an anti-alpha-v integrin (receptor) antibody to patients suffering from prostate cancer, especially castration-resistant prostate cancer (CRPC), optionally accompanied by lymph node and bone tissue metastases (mCRPC). In particular, the invention relates to the therapy of said patients by means of the anti-angiogenic antibody DI17E6 and structural mutants thereof.Type: ApplicationFiled: January 9, 2017Publication date: August 3, 2017Applicant: Merck Patent GmbHInventors: Axel Hoffmann, Heinrich Lannert, Klaus Brischwein, Frederic Christian Pipp, Juergen Reindl, Karin Groll, Michael Zuehlsdorf, Otmar Pfaff, Sabine Raab, Ulrike Dau, Benoit Destenaves
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Patent number: 9555110Abstract: The invention is directed to the treatment of prostate cancer by means of antibodies. Above all, the invention relates to the administration of an anti-alpha-v integrin (receptor) antibody to patients suffering from prostate cancer, especially castration-resistant prostate cancer (CRPC), optionally accompanied by lymph node and bone tissue metastases (mCRPC). In particular, the invention relates to the therapy of said patients by means of the anti-angiogenic antibody DI17E6 and structural mutants thereof.Type: GrantFiled: February 7, 2012Date of Patent: January 31, 2017Assignee: Merck Patent GmbHInventors: Axel Hoffmann, Heinrich Lannert, Klaus Brischwein, Frederic Christian Pipp, Juergen Reindl, Karin Groll, Michael Zuehlsdorf, Otmar Pfaff, Sabine Raab, Ulrike Dau, Benoit Destenaves
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Publication number: 20140086908Abstract: The invention is directed to the treatment of prostate cancer by means of antibodies. Above all, the invention relates to the administration of an anti-alpha-v integrin (receptor) antibody to patients suffering from prostate cancer, especially castration-resistant prostate cancer (CRPC), optionally accompanied by lymph node and bone tissue metastases (mCRPC). In particular, the invention relates to the therapy of said patients by means of the anti-angiogenic antibody DI17E6 and structural mutants thereof.Type: ApplicationFiled: February 7, 2012Publication date: March 27, 2014Applicant: Merck Patent GmbHInventors: Axel Hoffmann, Heinrich Lannert, Klaus Brischwein, Frederic Christian Pipp, Juergen Reindl, Karib Groll, Michael Zuehlsdorf, Otmar Pfaff, Sabine Raab, Ulrike Dau, Benoit Destenaves
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Publication number: 20080088984Abstract: A method is provided for producing a lithographic pattern using a mask that includes the same materials as the material to be etched, allowing the pattern to be transferred and the etch mask to be removed in one step. In accordance with features of the invention, the method includes building up of a layer or layers of material of specific thickness on top of a substrate so that temporal control of an etching process allows formation of the desired pattern. Different exchange bias directions can be established by the use of shape anisotropy for the exchange biased component of a spin valve device. This enables several different magnetic reference directions to be present on a single chip, which allows a more compact magnetic field sensor to be developed.Type: ApplicationFiled: December 7, 2007Publication date: April 17, 2008Applicant: UChicago Argonne, LLCInventor: Axel Hoffmann
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Patent number: 7323113Abstract: A method is provided for producing a lithographic pattern using a mask that includes the same materials as the material to be etched, allowing the pattern to be transferred and the etch mask to be removed in one step. In accordance with features of the invention, the method includes building up of a layer or layers of material of specific thickness on top of a substrate so that temporal control of an etching process allows formation of the desired pattern. Different exchange bias directions can be established by the use of shape anisotropy for the exchange biased component of a spin valve device. This enables several different magnetic reference directions to be present on a single chip, which allows a more compact magnetic field sensor to be developed. In accordance with features of the invention, different field directions are established on one single chip by using shape anisotropy.Type: GrantFiled: November 3, 2004Date of Patent: January 29, 2008Assignee: UChicago Argonne, LLCInventor: Axel Hoffmann
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Publication number: 20060240456Abstract: Nanosized biological containers that are “ghosts” of viruses for which capsids are independent of their endogenous viral nucleic acid cores, provide nano-particles of uniform size, and known numbers of sites for attachments of ligands. These containers can be filled with a fluorescent, magnetic, x-ray absorbent, nucleotide components or a radioactive particle and used as nanoscale markers.Type: ApplicationFiled: March 20, 2006Publication date: October 26, 2006Inventors: Liaohai Chen, Samuel Bader, Axel Hoffmann, Brian Kay, Lee Makowski
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Publication number: 20060028863Abstract: A method for implementing miniaturization of magnetic random access memory (MRAM) and a magnetic memory using single domain switching by direct current are provided. The magnetic memory preferably includes a half-circle or U-shaped architecture with an exchange biasing pad, such as a FeMn exchange biasing pad that effectively generates a head-to-head magnetization configuration. The magnetic memory also includes nanometer scale notches in order to minimize magnetostatic interaction between a single domain memory element and the spin current sources and to effectively trap the magnetic domain wall. Reading the bit can be carried out by anisotropic magnetoresistance, or by other means of determining the magnetization orientation through resistance measurements, such as a spin valve or a magnetic tunneling junction.Type: ApplicationFiled: August 5, 2004Publication date: February 9, 2006Inventors: Seok-Hwan Chung, Axel Hoffmann
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Publication number: 20050111146Abstract: A method is provided for producing a lithographic pattern using a mask that includes the same materials as the material to be etched, allowing the pattern to be transferred and the etch mask to be removed in one step. In accordance with features of the invention, the method includes building up of a layer or layers of material of specific thickness on top of a substrate so that temporal control of an etching process allows formation of the desired pattern. Different exchange bias directions can be established by the use of shape anisotropy for the exchange biased component of a spin valve device. This enables several different magnetic reference directions to be present on a single chip, which allows a more compact magnetic field sensor to be developed.Type: ApplicationFiled: November 3, 2004Publication date: May 26, 2005Inventor: Axel Hoffmann
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Patent number: 5976811Abstract: Antibodies for the selective immunological determination of bile acids in biological matricesPolyclonal antibodies for the selective immunological determination of bile acids in biological matrices, a process for the preparation of these antibodies, and their use in immunoassays are described.Type: GrantFiled: February 28, 1997Date of Patent: November 2, 1999Assignee: Hoescht AktiengesellschaftInventors: Stefan Mullner, Axel Hoffmann
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Patent number: 5939424Abstract: The invention relates to 4-Amino-2-ureidopyrimidine-5-carboxamides of the formula I ##STR1## in which R.sup.1 is H or (C.sub.1 -C.sub.8)-alkyl, where one or more H can be replaced by F; R.sup.2 is selected from the group consisting of F, Cl, Br, H, -O-(C.sub.1 -C.sub.8)-alkyl, and -S-(C.sub.1 -C.sub.8)-alkyl, where the alkyl groups have one or more H replaced by F; R.sup.3 is -O-(C.sub.1 -C.sub.8)-alkyl or -S-(C.sub.1 -C.sub.8)-alkyl, where the alkyl groups have one or more H replaced by F; or R.sup.2 and R.sup.3 together form -O-(C.sub.1 -C.sub.5)-alkylene-O-, where the alkylene portion has one or more H replaced by F; and their physiologically tolerable salts. The invention further provides processes for preparing the compounds of formula I. The compounds are suitable for the treatment of disorders of lipid metabolism.Type: GrantFiled: June 4, 1997Date of Patent: August 17, 1999Assignee: Hoechst AktiengesellschaftInventors: Hans Georg Boger, Axel Hoffmann, Gerhard Jahne, Norbert Krass, Hans-Ludwig Schafer
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Patent number: 5773447Abstract: The present invention relates to tertiary 4-amino-2-ureidopyrimidine-5-carboxamides of formula I: ##STR1## in which R.sup.1 is (C.sub.1 -C.sub.8)-alkyl wherein one or more H are replaced by F; R.sup.2 is selected from the group consisting of F, Cl, Br, H, --O--(C.sub.1 -C.sub.8)-alkyl and (C.sub.1 -C.sub.8)-alkyl, wherein one or more of the H of the alkyls can be replaced by F; R.sup.3 is selected from the group consisting of F, Cl, Br, H, --O--(C.sub.1 -C.sub.4)-alkyl and (C.sub.1 -C.sub.4)-alkyl, wherein one or more of the H of the alkyl can be replaced by F; R.sup.4 is CF.sub.3 or OCF.sub.3 ; and their physiologically tolerable salts. Process for preparing the compounds of formula I are also described. The compounds are suitable for the treatment of disorders of lipid metabolism.Type: GrantFiled: June 13, 1997Date of Patent: June 30, 1998Assignee: Hoechst AktiengesellschaftInventors: Gerhard Rackur, Hans Georg Boger, Norbert Krass, Axel Hoffmann, Michael Leineweber
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Patent number: 4883656Abstract: A composition and method for the oxidative dyeing of hair based on a combination of coupler substance and developer substance, wherein they contain(A) 5-amino-2-methylphenol as coupler substance and(B) 4-amino-3-methylphenol and(C) 1,4-diaminobenzene and/or 2,5-diaminotolueneas developer substances, also in the form of the physiologically compatible salts.The new composition enables the production of neutral red color shades which are free from yellow and virtually free of blue portions and, in addition to the high dye intensity and brilliance, have an outstanding dye equality with very good absorptive power.Type: GrantFiled: November 12, 1987Date of Patent: November 28, 1989Assignee: Wella AktiengesellschaftInventors: Eugen Konrad, Herbert Mager, Axel Hoffmann