Patents by Inventor Axel J. Unterbeck

Axel J. Unterbeck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Molecular diagnosis of Alzheimer Disease
    Patent number: 5015570
    Abstract: A method for diagnosing Alzheimer Disease or a predisposition to develop Alzheimer Disease in an individual, by determining the presence of an alteration in the normal base sequence of the 24 base pairs appearing at the end of the APC coding sequence of the preAPC gene, or in the normal base sequence of the corresponding mRNA, in the DNA or RNA or such individual. The method detects the presence of a frameshift mutation in the preAPC gene postulated to result in the synthesis of the APC protein. Accumulation of APC protein in the brain is a phenomenon of Alzheimer Disease. A variety of nucleic acid hybridization techniques are applicable to the determination of an alteration in the preAPC gene sequence of interest.
    Type: Grant
    Filed: May 13, 1988
    Date of Patent: May 14, 1991
    Assignee: Molecular Therapeutics, Inc.
    Inventors: George A. Scangos, Peter M. M. Rae, Axel J. Unterbeck, Michael E. Kamarck