Abstract: A method of analyzing a patient tissue sample to determine its diseased tissue fraction while essentially preserving the genomic and/or proteomic and/or epigenomic and/or biophysical properties of the tissue sample. The method includes preparing sections from the tissue sample, subjecting at least one of the sections to a histological/cytological examination, and subjecting at least another one of the sections to a non-morphological analytical testing. In the histological/cytological examination, a quantitative fraction of diseased tissue/cells and/or another morphological aspect is determined by an image processing system, and the determined quantitative fraction of diseased tissue/cells and/or another morphological aspect is used as a reference quantity on which evaluation of the result of the non-morphological analytical testing is based.

Abstract: An apparatus for the micro-dissection of tissue with a fine needle, which is arranged on holder movable in space along three axes and the tip of which can be moved with the holder relative to the tissue, which is to be severed, wherein the needle is coupled with an oscillating drive mechanism, which causes the needle to oscillate in the longitudinal and/or transverse direction at a predetermined amplitude and frequency.