Patents by Inventor Axel Trefzer

Axel Trefzer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240101999
    Abstract: The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).
    Type: Application
    Filed: August 17, 2023
    Publication date: March 28, 2024
    Inventors: Thomas POEHMERER, Phillip KUHN, Frank NOTKA, Andreas ZEIDLER, Korbinian HEIL, Axel TREFZER, Geir FONNUM, Federico KATZEN, Kristian ANDERSSON, Xiquan LIANG
  • Publication number: 20220177939
    Abstract: The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).
    Type: Application
    Filed: August 18, 2021
    Publication date: June 9, 2022
    Inventors: Todd PETERSON, Axel TREFZER, Thomas POEHMERER
  • Publication number: 20220090161
    Abstract: The present disclosure generally relates to devices, compositions and methods for designing and producing nucleic acid molecules and the production of encoded proteins using these nucleic acid molecules. In some aspect, the disclosure relates to automation for the in vitro generation of coding DNA molecules, the in vitro transcription of these DNA molecules to generate protein coding RNA molecules, and the in vitro translation of these protein coding RNA molecules to produce proteins.
    Type: Application
    Filed: August 27, 2021
    Publication date: March 24, 2022
    Inventors: Claudia CHIOCCHINI, Axel TREFZER, Krishna VATTEM, Phillip KUHN
  • Publication number: 20210388346
    Abstract: The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).
    Type: Application
    Filed: May 14, 2021
    Publication date: December 16, 2021
    Inventors: Todd PETERSON, Axel TREFZER, Thomas POEHMERER
  • Publication number: 20210222219
    Abstract: The disclosure generally relates to compositions and methods for the enzymatic synthesis of nucleic acid sequences. In particular embodiments 3? protected nucleotides are used in conjunction with a universal template to direct synthesis.
    Type: Application
    Filed: December 28, 2020
    Publication date: July 22, 2021
    Inventors: Christian KRANZ, Michael LISS, Axel TREFZER
  • Patent number: 11046953
    Abstract: The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: June 29, 2021
    Assignees: Life Technologies Corporation, Thermo Fisher Scientific GENEART GmbH
    Inventors: Todd Peterson, Axel Trefzer, Thomas Poehmerer
  • Publication number: 20200325514
    Abstract: The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).
    Type: Application
    Filed: January 7, 2020
    Publication date: October 15, 2020
    Inventors: Todd PETERSON, Axel TREFZER, Thomas POEHMERER, Federico KATZEN, Xiquan LIANG
  • Publication number: 20200172898
    Abstract: The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).
    Type: Application
    Filed: November 8, 2019
    Publication date: June 4, 2020
    Inventors: Todd PETERSON, Axel TREFZER, Thomas POEHMERER
  • Patent number: 10563240
    Abstract: The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: February 18, 2020
    Assignees: LIFE TECHNOLOGIES CORPORATION, THERMO FISHER SCIENTIFIC GENEART GMBH
    Inventors: Todd Peterson, Axel Trefzer, Thomas Poehmerer, Federico Katzen, Xiquan Liang
  • Publication number: 20200010827
    Abstract: The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).
    Type: Application
    Filed: July 22, 2019
    Publication date: January 9, 2020
    Inventors: Thomas Poehmerer, Phillip Kuhn, Frank Notka, Andreas Zeidler, Korbinian Heil, Axel Trefzer, Geir Fonnum, Federico Katzen, Kristian Andersson, Xiquan Liang
  • Patent number: 10519439
    Abstract: The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: December 31, 2019
    Assignees: LIFE TECHNOLOGIES CORPORATION, THERMO FISHER SCIENTIFIC GENEART GMBH
    Inventors: Todd Peterson, Axel Trefzer, Thomas Poehmerer
  • Patent number: 10407676
    Abstract: The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: September 10, 2019
    Assignees: LIFE TECHNOLOGIES CORPORATION, THERMO FISHER SCIENTIFIC GENEART GMBH, LIFE TECHNOLOGIES AS
    Inventors: Thomas Poehmerer, Phillip Kuhn, Frank Notka, Andreas Zeidler, Korbinian Heil, Axel Trefzer, Geir Fonnum, Federico Katzen, Kristian Andersson
  • Patent number: 10196617
    Abstract: This invention relates to phytases, polynucleotides encoding them, uses of the polynucleotides and polypeptides of the invention, as well as the production and isolation of such polynucleotides and polypeptides. In particular, the invention provides polypeptides having phytase activity under high temperature conditions, and phytases that retain activity after exposure to high temperatures. The phytases of the invention can be thermotolerant and/or thermostable at low temperatures, in addition to higher temperatures. The phytases of the invention can be used in foodstuffs to improve the feeding value of phytate rich ingredients. The phytases of the invention can be formulated as foods or feeds or supplements for either to, e.g., aid in the digestion of phytate. The foods or feeds of the invention can be in the form of pellets, liquids, powders and the like.
    Type: Grant
    Filed: October 2, 2014
    Date of Patent: February 5, 2019
    Assignee: BASF Enzymes LLC
    Inventors: Arne Solbak, Brian Steer, Mark Dycaico, Katie A. Kline, Axel Trefzer, Thomas Todaro, Fatima El-Farrah, Alberto Alvarado, Gerhard Frey
  • Publication number: 20180291413
    Abstract: The present disclosure generally relates to devices, compositions and methods for designing and producing nucleic acid molecules and the production of encoded proteins using these nucleic acid molecules. In some aspect, the disclosure relates to automation for the in vitro generation of coding DNA molecules, the in vitro transcription of these DNA molecules to generate protein coding RNA molecules, and the in vitro translation of these protein coding RNA molecules to produce proteins.
    Type: Application
    Filed: October 4, 2016
    Publication date: October 11, 2018
    Inventors: Claudia CHIOCCHINI, Axel TREFZER, Krishna VATTEM, Phillip KUHN
  • Publication number: 20180195099
    Abstract: The disclosure generally relates to compositions and methods for the enzymatic synthesis of nucleic acid sequences. In particular embodiments 3? protected nucleotides are used in conjunction with a universal template to direct synthesis.
    Type: Application
    Filed: July 7, 2016
    Publication date: July 12, 2018
    Inventors: Christian KRANZ, Michael LISS, Axel TREFZER
  • Publication number: 20170260521
    Abstract: The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).
    Type: Application
    Filed: March 20, 2017
    Publication date: September 14, 2017
    Inventors: Todd PETERSON, Axel TREFZER, Thomas POEHMERER
  • Publication number: 20160186166
    Abstract: The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).
    Type: Application
    Filed: December 9, 2015
    Publication date: June 30, 2016
    Inventors: Thomas POEHMERER, Phillip Kuhn, Frank Notka, Andreas Zeidler, Korbinian Heil, Axel Trefzer, Geir Fonnum, Federico Katzen, Kristian Andersson, Xiquan Liang
  • Publication number: 20160122792
    Abstract: The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).
    Type: Application
    Filed: March 14, 2014
    Publication date: May 5, 2016
    Inventors: Todd PETERSON, Axel TREFZER, Thomas POEHMERER, Federico KATZEN, Xiquan LIANG
  • Publication number: 20150344876
    Abstract: The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).
    Type: Application
    Filed: June 4, 2015
    Publication date: December 3, 2015
    Inventors: Todd PETERSON, Axel Trefzer, Thomas Poehmerer
  • Publication number: 20150132383
    Abstract: This invention relates to phytases, polynucleotides encoding them, uses of the polynucleotides and polypeptides of the invention, as well as the production and isolation of such polynucleotides and polypeptides. In particular, the invention provides polypeptides having phytase activity under high temperature conditions, and phytases that retain activity after exposure to high temperatures. The phytases of the invention can be thermotolerant and/or thermostable at low temperatures, in addition to higher temperatures. The phytases of the invention can be used in foodstuffs to improve the feeding value of phytate rich ingredients. The phytases of the invention can be formulated as foods or feeds or supplements for either to, e.g., aid in the digestion of phytate. The foods or feeds of the invention can be in the form of pellets, liquids, powders and the like.
    Type: Application
    Filed: October 2, 2014
    Publication date: May 14, 2015
    Inventors: Arne SOLBAK, Brian STEER, Mark DYCAICO, Katie A. KLINE, Axel TREFZER, Thomas TODARO, Fatima EL-FARRAH, Alberto ALVARADO, Gerhard FREY