Patents by Inventor Axel Unterbeck

Axel Unterbeck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phosphodiesterase 4 inhibitors
    Publication number: 20110046146
    Abstract: PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula I: wherein R1, R2, R3and R4 are as defined herein.
    Type: Application
    Filed: November 21, 2006
    Publication date: February 24, 2011
    Inventors: Richard Schumacher, William Brubaker, Michael De Vivo, Hans-Jurgen Hess, Allen Hopper, Ashok Tehim, Ruiping Liu, Axel Unterbeck
  • COMPOSITIONS AND METHODS OF TREATMENT USING L-TYPE CALCIUM CHANNEL BLOCKERS AND CHOLINESTERASE INHIBITORS
    Publication number: 20090156639
    Abstract: The present invention relates to composition comprising at least one L-type calcium channel blocker, particularly the compound (+)-isopropyl 2-methoxyethyl 4-(2-chloro-3-cyano-phenyl)-1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylate, in combination with at least one cholinesterase inhibitor, particularly donepezil, and uses thereof in methods of treatment.
    Type: Application
    Filed: February 20, 2009
    Publication date: June 18, 2009
    Inventors: Crista Trippodi-Murphy, Gregory M. Rose, Axel Unterbeck
  • METHODS OF TREATMENT USING (+)- ISOPROPYL 2-METHOXYETHYL 4-(2-CHLORO-3-CYANO-PHENYL)-1, 4-DIHYDRO-2, 6-DIMETHYL-PYRIDINE-3, 5-DICARBOXYLATE
    Publication number: 20090069361
    Abstract: The present invention relates to methods of treatment using the compound (+)-isopropyl 2-methoxyethyl 4-(2-chloro-3-cyano-phenyl)-1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylate, as a sole active agent or in combination with other pharmacological agents.
    Type: Application
    Filed: October 30, 2008
    Publication date: March 12, 2009
    Applicant: Memory Pharmaceuticals Corporation
    Inventors: Axel Unterbeck, Michael De Vivo, Gregory M. Rose
  • PHOSPHODIESTERASE 4 INHIBITORS, INCLUDING N-SUBSTITUTED ANILINE AND DIPHENYLAMINE ANALOGS
    Publication number: 20090048255
    Abstract: PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula I: wherein R1, R2, R3 and R4 are as defined herein.
    Type: Application
    Filed: July 17, 2008
    Publication date: February 19, 2009
    Inventors: Richard A. SCHUMACHER, Allen T. HOPPER, Ashok TEHIM, Hans-Jurgen Ernst HESS, Axel UNTERBECK, Erik KUESTER, William Frederick BRUBAKER, JR., Robert F. DUNN
  • Phosphodiesterase 4 inhibitors, including N-substituted aniline and diphenylamine analogs
    Patent number: 7405230
    Abstract: PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula I: wherein R1, R2, R3 and R4 are as defined herein.
    Type: Grant
    Filed: July 21, 2003
    Date of Patent: July 29, 2008
    Assignee: Memory Pharmaceuticals Corporation
    Inventors: Richard A. Schumacher, Allen T. Hopper, Ashok Tehim, Hans-Jurgen Ernst Hess, Axel Unterbeck, Erik Kuester, William Frederick Brubaker, Jr., Robert F. Dunn
  • Methods of Treatment Using (+)-Isopropyl 2-Ethoxyethyl-4-(2-Chloro-3-Cyano-Phenyl)-1,4-Dihydro-2,6-Dimethyl-Pyridine-3,5-Dicarboxylate
    Publication number: 20080026081
    Abstract: The present invention relates to methods of treatment using the compound (+)-isopropyl 2-methoxyethyl 4-(2-chloro-3-cyano-phenyl)-1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylate, as a sole active agent or in combination with other pharmacological agents.
    Type: Application
    Filed: November 19, 2004
    Publication date: January 31, 2008
    Inventors: Axel Unterbeck, Michael De Vivo, Gregory M. Rose
  • Phosphodiesterase 4 inhibitors
    Patent number: 7205320
    Abstract: PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula I: wherein R1, R2, R3 and R4 are as defined herein.
    Type: Grant
    Filed: January 12, 2004
    Date of Patent: April 17, 2007
    Assignee: Memory Pharmaceuticals Corp.
    Inventors: Richard A. Schumacher, William F. Brubaker, Michael De Vivo, Hans-Jürgen Ernst Hess, Allen Hopper, Ashok Tehim, Ruiping Liu, Axel Unterbeck
  • Phosphodiesterase 4 inhibitors
    Publication number: 20070078139
    Abstract: PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula I: wherein R1, R2, R3and R4 are as defined herein.
    Type: Application
    Filed: November 21, 2006
    Publication date: April 5, 2007
    Inventors: Richard Schumacher, William Brubaker, Michael De Vivo, Hans-Jurgen Hess, Allen Hopper, Ashok Tehim, Ruiping Liu, Axel Unterbeck
  • CYCLIC AMP PHOSPHODIESTERASE 4D7 ISOFORMS AND METHODS OF USE
    Publication number: 20050289660
    Abstract: Abstract of the Disclosure Human, rat and mouse cAMP phosphodiesterase isoforms (denoted PDE4D7s), as well as the DNA (RNA) encoding such polypeptides, are disclosed. Also disclosed are methods for utilizing such polypeptides in diagnostic assays for identifying mutations in nucleic acid sequences encoding the polypeptides of the present invention, for detecting altered levels of the polypeptide of the present invention as a means of detecting diseases and methods of screening potential modulators, especially inhibitors, of the novel PDE4D7s disclosed herein. Such as inhibitors can be used, for example, as a means of increasing cyclic AMP in neurons and thus treating neurological problems, such as long term memory loss, if not preventing such maladies entirely. Transgenic animals expressing polypeptides disclosed herein are also described.
    Type: Application
    Filed: December 2, 2004
    Publication date: December 29, 2005
    Applicant: Memory Pharmaceuticals Corporation
    Inventors: Daguang Wang, Xiaonan Xin, Axel Unterbeck, Christopher Leonard, Michael De Vivo
  • Compositions and methods of treatment using L-type calcium channel blockers and cholinesterase inhibitors
    Publication number: 20050153953
    Abstract: The present invention relates to compositions comprising at least one L-type calcium channel blocker, particularly the compound (+)-isopropyl 2-methoxyethyl 4-(2-chloro-3-cyano-phenyl)-1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylate, in combination with at least one cholinesterase inhibitor, particularly donepezil, and uses thereof in methods of treatment.
    Type: Application
    Filed: November 19, 2004
    Publication date: July 14, 2005
    Inventors: Crista Trippodi-Murphy, Gregory Rose, Axel Unterbeck
  • Cyclic amp phosphodiesterase 4d7 isoforms and methods of use
    Publication number: 20050132428
    Abstract: Human, rat and mouse cAMP phosphodiesterase isoforms (denoted PDE4D7s), as well as the DNA (RNA) encoding such polypeptides, are disclosed. Also disclosed are methods for utilizing such polypeptides in diagnostic assays for identifying mutations in nucleic acid sequences encoding the polypeptides of the present invention, for detecting altered levels of the polypeptide of the present invention as a means of detecting diseases and methods of screening potential modulators, especially inhibitors, of the novel PDE4D7s disclosed herein. Such as inhibitors can be used, for example, as a means of increasing cyclic AMP in neurons and thus treating neurological problems, such as long term memory loss, if not preventing such maladies entirely. Transgenic animals expressing polypeptides disclosed herein are also described.
    Type: Application
    Filed: November 15, 2002
    Publication date: June 16, 2005
    Inventors: Daguang Wang, Xiaonan Xin, Axel Unterbeck, Christopher Leonard, Michael Vivo
  • Phosphodiesterase 4 inhibitors, including N-substituted aniline and diphenylamine analogs
    Publication number: 20050119225
    Abstract: PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula I: wherein R1, R2, R3 and R4 are as defined herein.
    Type: Application
    Filed: July 21, 2003
    Publication date: June 2, 2005
    Applicant: MEMORY PHARMACEUTICALS CORP.
    Inventors: Richard Schumacher, Allen Hopper, Ashok Tehim, Hans-Jurgen Hess, Axel Unterbeck, Erik Kuester, William Brubaker, Robert Dunn
  • Phosphodiesterase 4 inhibitors
    Publication number: 20040230072
    Abstract: PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs.
    Type: Application
    Filed: January 12, 2004
    Publication date: November 18, 2004
    Inventors: Richard A. Schumacher, William F. Brubaker, Michael De Vivo, Hans-Jurgen Ernst Hess, Allen Hopper, Ashok Tehim, Ruiping Liu, Axel Unterbeck
  • Cyclic AMP phosphodiesterase isoforms and methods of use
    Publication number: 20040185465
    Abstract: Human and rat cAMP phosphodiesterase isoforms (denoted PDE4Ds), as well as the DNA (RNA) encoding such polypeptides, are disclosed. Also disclosed are methods for utilizing such polypeptides in diagnostic assays for identifying mutations in nucleic acid sequences encoding the polypeptides of the present invention, for detecting altered levels of the polypeptide of the present invention as a means of detecting diseases and methods of screening potential modulators, especially inhibitors, of the novel PDE4Ds (denoted PDE4D6) disclosed herein as a means of increasing cyclic AMP in neurons and thus treating neurological problems, such as long term memory loss, if not preventing such maladies entirely. Transgenic animals expressing polypeptides disclosed herein are also described.
    Type: Application
    Filed: October 10, 2003
    Publication date: September 23, 2004
    Inventors: Xiaonan Xin, Axel Unterbeck, Yinghe Hu
  • Phosphodiesterase 4 inhibitors
    Patent number: 6699890
    Abstract: PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula I: wherein R1, R2 , R3 and R4 are as defined herein.
    Type: Grant
    Filed: January 22, 2002
    Date of Patent: March 2, 2004
    Assignee: Memory Pharmaceuticals Corp.
    Inventors: Richard A. Schumacher, William F. Brubaker, Michael De Vivo, Hans-Jürgen Ernst Hess, Allen Hopper, Ashok Tehim, Ruiping Liu, Axel Unterbeck
  • Cyclic AMP phosphodiesterase isoforms and methods of use
    Patent number: 6656717
    Abstract: Human and rat cAMP phosphodiesterase isoforms (denoted PDE4Ds), as well as the DNA (RNA) encoding such polypeptides, are disclosed. Also disclosed are methods for utilizing such polypeptides in diagnostic assays for identifying mutations in nucleic acid sequences encoding the polypeptides of the present invention, for detecting altered levels of the polypeptide of the present invention as a means of detecting diseases and methods of screening potential modulators, especially inhibitors, of the novel PDE4Ds (denoted PDE4D6) disclosed herein as a means of increasing cyclic AMP in neurons and thus treating neurological problems, such as long term memory loss, if not preventing such maladies entirely. Transgenic animals expressing polypeptides disclosed herein are also described.
    Type: Grant
    Filed: June 23, 2000
    Date of Patent: December 2, 2003
    Assignee: Memory Pharmaceuticals Corp.
    Inventors: Xiaonan Xin, Axel Unterbeck, Yinghe Hu
  • Phosphodiesterase 4 inhibitors
    Publication number: 20030149052
    Abstract: PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs.
    Type: Application
    Filed: February 11, 2003
    Publication date: August 7, 2003
    Applicant: MEMORY PHARMACEUTICALS CORP.
    Inventors: Richard A. Schumacher, William F. Brubaker, Michael De Vivo, Hans-Jurgen Ernst Hess, Allen Hopper, Ashok Tehim, Ruiping Liu, Axel Unterbeck
  • Phosphodiesterase 4 inhibitors
    Publication number: 20020151566
    Abstract: PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs.
    Type: Application
    Filed: January 22, 2002
    Publication date: October 17, 2002
    Applicant: MEMORY PHARMACEUTICALS CORP.
    Inventors: Richard A. Schumacher, William F. Brubaker, Michael De Vivo, Hans-Jurgen Ernst Hess, Allen Hopper, Ashok Tehim, Ruiping Liu, Axel Unterbeck
  • Tissue-specific human neuronal calcium channel subtypes and their use
    Patent number: 6229000
    Abstract: Disclosed are overlapping cDNA sequences encoding for a human voltage-dependent neuronal calcium channel. The complete cDNA which encodes a voltage-operated calcium channel (VOCC) sub-type is assembled from overlapping lambda phages by means of suitable restriction cleavage sites and cloned into a eukaryotic expression vector.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: May 8, 2001
    Assignee: Bayer Aktiengesellschaft
    Inventors: Jürgen Franz, Bernhard Weingärtner, Axel Unterbeck, Peter Rae
  • Human neuronal beta subunits of voltage-operated calcium channels and the use thereof
    Patent number: 5643750
    Abstract: The present invention relates to human neuronal beta subunits of voltage-operated calcium channels and the use thereof in screening methods for finding pharmaceuticals which modulate the activity of these calcium channels.
    Type: Grant
    Filed: November 21, 1994
    Date of Patent: July 1, 1997
    Assignee: Bayer Aktiengesellschaft
    Inventors: Peter Spreyer, Axel Unterbeck