Patents by Inventor Axel Walch

Axel Walch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9164098
    Abstract: A method for determining an expression of human epidermal growth factor receptor 2 (HER2) of a subject. The method includes providing a sample from the subject; measuring one of (i) amounts of two or more proteins in the sample, each protein having a molecular weight substantially equal to 4740, 8404, 8419, 8435, 8450, 8455, 8465, 8570, 8607 or 8626 atomic mass units, and (ii) amounts of at least one of human cystein-rich intestinal protein 1 (CRIP1), one or more variants of the human cystein-rich intestinal protein 1 (CRIP1 variants), and proteolytic digestion products thereof in the sample; and comparing the amounts of the proteins to control amounts, which control amounts are determinative of the expression of the human epidermal growth factor receptor 2.
    Type: Grant
    Filed: September 10, 2010
    Date of Patent: October 20, 2015
    Assignee: Bruker Daltonik GmbH
    Inventors: Christian Albers, Eckhard Belau, Sören-Oliver Deininger, Sandra Rauser, Detlev Suckau, Axel Walch
  • Publication number: 20110059554
    Abstract: A method for determining an expression of human epidermal growth factor receptor 2 (HER2) of a subject. The method includes providing a sample from the subject; measuring one of (i) amounts of two or more proteins in the sample, each protein having a molecular weight substantially equal to 4740, 8404, 8419, 8435, 8450, 8455, 8465, 8570, 8607 or 8626 atomic mass units, and (ii) amounts of at least one of human cystein-rich intestinal protein 1 (CRIP1), one or more variants of the human cystein-rich intestinal protein 1 (CRIP1 variants), and proteolytic digestion products thereof in the sample; and comparing the amounts of the proteins to control amounts, which control amounts are determinative of the expression of the human epidermal growth factor receptor 2.
    Type: Application
    Filed: September 10, 2010
    Publication date: March 10, 2011
    Inventors: Christian Albers, Eckhard Belau, Sören-Oliver Deininger, Sandra Rauser, Detlev Suckau, Axel Walch
  • Publication number: 20090289184
    Abstract: The present invention relates to a method for the histologic classification of a tissue section. The method includes acquiring a mass spectrometric image and a light-optical image of the same tissue section (the optical image having a higher spatial resolution than the mass spectrometric image) and combining optical information on the structures of a subarea of the tissue section with mass spectrometric information on the subarea (the structures not being spatially resolved in the mass spectrometric image).
    Type: Application
    Filed: May 14, 2009
    Publication date: November 26, 2009
    Inventors: Soren-Oliver Deininger, Axel Walch
  • Patent number: 6037467
    Abstract: Carbohydrate-containing polymers which can have an HLB* of from about 10 to about 20 are disclosed. The compounds comprise a hydrophilic polymer portion, a carbohydrate portion comprising from 1 to about 20 naturally occurring, identical or different, monosaccharide units, at least one bifunctional spacer coupling the carbohydrate portion to the hydrophilic polymer portion, and a potentiator moiety. The potentiator moiety can be is a crosslinking moiety located within the hydrophilic polymer or a hydrophobic, hydrophilic or ionic moiety. Processes for the preparation and use of such polymers are also disclosed.
    Type: Grant
    Filed: July 24, 1997
    Date of Patent: March 14, 2000
    Assignee: Glycorex AB
    Inventors: Wilhelm Stahl, Michael Ahlers, Axel Walch, Eckhart Bartnik, Gerhard Kretzschmar, Susanne Grabley, Rudolf Schleyerbach
  • Patent number: 6036948
    Abstract: Polyaspartamide derivatives as adsorbents for bile acids, polyaspartamide derivatives loaded with bile acids and process for their preparation and their use as pharmaceuticals.alpha.- or .beta.-linked polyaspartamide derivatives of the formula I ##STR1## in which R.sup.I, R.sup.II, R.sup.III, R.sup.IV, r, s, t, u and v have the stated meanings, are described. They adsorb bile acids and can be used as pharmaceuticals.
    Type: Grant
    Filed: October 22, 1997
    Date of Patent: March 14, 2000
    Inventors: Volker Krone, Axel Walch, Stefan Mullner, Ernold Granzer
  • Patent number: 5714138
    Abstract: Polyaspartamide derivatives as adsorbents for bile acids, polyaspartamide derivatives loaded with bile acids and process for their preparation and their use as pharmaceuticals.alpha..sup.- or .beta.-linked polyaspartamide derivatives of the formula I ##STR1## in which R.sup.I R.sup.II, R.sup.III, R.sup.IV, r, s, t, u and v have the stated meanings, are described. They adsorb bile acids and can be used as pharmaceuticals.
    Type: Grant
    Filed: December 10, 1993
    Date of Patent: February 3, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Volker Krone, Axel Walch, Stefan Mullner, Ernold Granzer
  • Patent number: 5700459
    Abstract: The invention relates to a pharmacological composition comprising a polyelectrolyte complex, in particular a polyacid with an average particle size of less than 15 .mu.m and an active agent, among which are active peptides, proteins, enzymes, enzyme inhibitors, antigens, cytostatics, antiinflamatory agents, antibiotics and vaccines. The said composition ensures that the active agent is converted in a non-deleterious manner into a form which can be administered. In addition, the biodistribution, bioavailability and absorption of the pharmaceutical are beneficially affected.
    Type: Grant
    Filed: November 16, 1994
    Date of Patent: December 23, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Volker Krone, Michael Magerstadt, Axel Walch, Albrecht Groner, Dieter Hoffmann
  • Patent number: 5674531
    Abstract: Nanoparticles containing an active substance and a ketalized polytartramidic acid, process for their preparation, and use thereof. Nanoparticles containing an active substance and a ketalized polytartramidic acid are suitable as vehicles for active substances, in particular for peptides and proteins. Processes for the preparation of the nanoparticles are described.
    Type: Grant
    Filed: March 7, 1995
    Date of Patent: October 7, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Michael Ahlers, Axel Walch, Gerhard Seipke, Gregory Russell-Jones
  • Patent number: 5631326
    Abstract: Crosslinked, nitrogen-containing vinyl copolymers having units of the formula I ##STR1## and physiologically tolerated salts thereof, in which, in formula I, A1, A2, R, w, x, y and z have the meanings given, a process for their preparation and the use of the compounds as medicaments, active compound carriers and foodstuff auxiliaries are described.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: May 20, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Michael Ahlers, Heiner Glombik, Stefan M ullner, Axel Walch
  • Patent number: 5613494
    Abstract: Polycondensates which contain tartaric acid derivatives, processes for their preparation and use thereof.The invention relates to polycondensates which consist of at least 95 mol % of recurring structural units of the formula I ##STR1## where R.sup.1 is a 2,3-O-alkylidenetartaric acid derivative (II) or furo[2,5] (V), alkyl, alkenyl, cycloalkyl, cycloalkenyl, aryl or a heterocycle, X is --O-- --NH-- or --S-- and R.sup.2 is 2,3-O-alkylidene-L-threitol (III) or a compound of the formula VI, alkyl, alkenyl, cycloalkyl, cycloalkenyl, aryl or a heterocycle, with the proviso that more than 5 mol % of the radicals R.sup.1 and/or R.sup.2 are present in the polycondensate of the formula I, where R.sup.1 is compound of the formula II or R.sup.2 is a compound of the formula III or R.sup.1 is a compound of the formula II and R.sup.2 is a compound of the formula III, or in which more than 5 mol % of the radicals R.sup.1 and R.sup.2 are present in the polycondensate of the formula I, wherea) R.sup.
    Type: Grant
    Filed: May 4, 1995
    Date of Patent: March 25, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Volker Krone, Michael Magerstadt, Axel Walch, Gunter Ditzinger, Norbert Lill
  • Patent number: 5505784
    Abstract: The invention relates to polycondensates which consist of at least 95 mol % of recurring structural units of the formula I ##STR1## where R.sup.1 is a 2,3-O-alkylidenetartaric acid derivative (II) or furo[2,5] (V), alkyl, alkenyl, cycloalkyl, cycloalkenyl, aryl or a heterocycle, X is --O--, --NH-- or --S-- and R.sup.2 is 2,3-O-alkylidene-L-threitol (III) or a compound of the formula VI, alkyl, alkenyl, cycloalkyl, cycloalkenyl, aryl or a heterocycle, with the proviso that more than 5 mol % of the radicals R.sup.1 and/or R.sup.2 are present in the polycondensate of the formula I, where R.sup.1 is compound of the formula II or R.sup.2 is a compound of the formula III or R.sup.1 is a compound of the formula II and R.sup.2 is a compound of the formula III, or in which more than 5 mol % of the radicals R.sup.1 and R.sup.2 are present in the polycondensate of the formula I, wherea) R.sup.1 is a compound of the formula V and R.sup.2 is a compound of the formula VI, orb) R.sup.
    Type: Grant
    Filed: January 10, 1995
    Date of Patent: April 9, 1996
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Volker Krone, Michael Magerstadt, Axel Walch, Gunter Ditzinger, Norbert Lill
  • Patent number: 5470843
    Abstract: Carbohydrate-containing polymers which can have an HLB* of from about 10 to about 20 are disclosed. The compounds comprise a hydrophilic polymer portion, a carbohydrate portion comprising from 1 to about 20 naturally occurring, identical or different, monosaccharide units, at least one bifunctional spacer coupling the carbohydrate portion to the hydrophilic polymer portion, and a potentiator moiety. The potentiator moiety can be is a crosslinking moiety located within the hydrophilic polymer or a hydrophobic, hydrophilic or ionic moiety. Processes for the preparation and use of such polymers are also disclosed.
    Type: Grant
    Filed: December 13, 1993
    Date of Patent: November 28, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Wilhelm Stahl, Michael Ahlers, Axel Walch, Eckhart Bartnik, Gerhard Kretzschmar, Susanne Grabley, Rudolf Schleyerbach
  • Patent number: 5430110
    Abstract: Polyvinylamine derivatives having hydrophilic centers, processes for their preparation and the use of the compounds as a medicament, active compound carrier and foodstuff auxiliary.Polyvinylamine derivatives containing hydrophilic centers, of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, X, w, x, y and z have the meanings given, and a process for their preparation, and the use of these compounds as medicaments, active compound carriers and foodstuff auxiliaries are described. Highly pure polyvinylamines having the recurring unit of the formula Ia ##STR2## the preparation of which is likewise described, are used in particular as starting substances for the preparation.
    Type: Grant
    Filed: July 21, 1993
    Date of Patent: July 4, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Michael Ahlers, Heiner Glombik, Susanne Grabley, Ernold Granzer, Stefan Mullner, Axel Walch, Guan-Yu Xu
  • Patent number: 5428112
    Abstract: Crosslinked, nitrogen-containing vinyl copolymers having units of the formula I ##STR1## and physiologically tolerated salts thereof, in which, in formula I, A1, A2, R, w, x, y and z have the meanings given, a process for their preparation and the use of the compounds as medicaments, active compound carriers and foodstuff auxiliaries are described.
    Type: Grant
    Filed: July 21, 1993
    Date of Patent: June 27, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Michael Ahlers, Heiner Glombik, Stefan Mullner, Axel Walch
  • Patent number: 5391696
    Abstract: Polycondensates which contain tartaric acid derivatives, processes for their preparation and use thereof.The invention relates to polycondensates which consist of at least 95 mol % of recurring structural units of the formula I ##STR1## where R.sup.1 is a 2,3-O-alkylidenetartaric acid derivative (II) or furo[2,5] (V), alkyl, alkenyl, cycloalkyl, cycloalkenyl, aryl or a heterocycle, X is --O--, --NH-- or --S-- and R.sup.2 is 2,3-O-alkylidene-L-threitol (III) or a compound of the formula VI, alkyl, alkenyl, cycloalkyl, cycloalkenyl, aryl or a heterocycle, with the proviso that more than 5 mol % of the radicals R.sup.1 and/or R.sup.2 are present in the polycondensate of the formula I, where R.sup.1 is compound of the formula II or R.sup.2 is a compound of the formula III or R.sup.1 is a compound of the formula II and R.sup.2 is a compound of the formula III, or in which more than 5 mol % of the radicals R.sup.1 and R.sup.2 are present in the polycondensate of the formula I, wherea) R.sup.
    Type: Grant
    Filed: May 21, 1992
    Date of Patent: February 21, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Volker Krone, Michael Magerstadt, Axel Walch, Gunter Ditzinger, Norbert Lill
  • Patent number: 5317065
    Abstract: The invention relates to biologically degradable polymers, in particular polyaminodicarboxylic acid-co-anhydroaminodicarboxylic acid derivatives, to a process for their preparation and to the use thereof for depot preparations having controlled delivery of active compound.
    Type: Grant
    Filed: March 25, 1993
    Date of Patent: May 31, 1994
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Volker Krone, Axel Walch
  • Patent number: 5229469
    Abstract: The invention relates to biologically degradable polymers, in particular polyaminodicarboxylic acid-co-anhydroaminodicarboxylic acid derivatives, to a process for their preparation and to the use thereof for depot preparations having controlled delivery of active compound.
    Type: Grant
    Filed: January 29, 1991
    Date of Patent: July 20, 1993
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Volker Krone, Axel Walch
  • Patent number: 5205287
    Abstract: The invention relates to ultrasonic contrast agents composed of microparticles which contain a gas and polyamino-dicarboxylic acid-co-imide derivatives, to processes for their preparation and to their use as diagnostic and therapeutic agents.
    Type: Grant
    Filed: October 1, 1992
    Date of Patent: April 27, 1993
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Raimund Erbel, Rainer Zotz, Volker Krone, Michael Magerstadt, Axel Walch
  • Patent number: 5190982
    Abstract: The invention relates to ultrasonic contrast agents composed of microparticles which contain a gas and polyamino-dicarboxylic acid-co-imide derivatives, to processes for their preparation and to their use as diagnostic and therapeutic agents.
    Type: Grant
    Filed: May 26, 1992
    Date of Patent: March 2, 1993
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Raimund Erbel, Rainer Zotz, Volker Krone, Michael Magerstadt, Axel Walch
  • Patent number: 5137928
    Abstract: The invention relates to ultrasonic contrast agents composed of microparticles which contain a gas and polyamino-dicarboxylic acid-co-imide derivatives, to processes for their preparation and to their use as diagnostic and therapeutic agents.
    Type: Grant
    Filed: April 24, 1991
    Date of Patent: August 11, 1992
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Raimund Erbel, Rainer Zotz, Volker Krone, Michael Magerstadt, Axel Walch