Patents by Inventor Axel Winkel
Axel Winkel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11406367Abstract: A biopsy device is provided comprising a tubular member, a hollow shaft and an elongated fiber body. The hollow shaft may have a distal end and a shaft, wherein a laterally (sidewardly) facing notch is formed in the distal portion of the shaft. The elongated fiber body may include at least one optical fiber, preferably at least two optical fibers, with a distal end. The tubular member is movable relative to the shaft, between a first position in which the notch is covered by the tubular member, and a second position in which the notch is not covered by the tubular member. The fiber body is movable within the shaft, between a first position in which the distal end of the optical fiber is located at the distal end of the shaft with the elongated fiber body extending through the notch, and a second position in which the distal end of the at least one optical fiber is located proximally to the notch.Type: GrantFiled: June 26, 2018Date of Patent: August 9, 2022Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Waltherus Cornelis Jozef Bierhoff, Christian Reich, Martinus Bernardus Van Der Mark, Bernardus Hendrikus Wilhelmus Hendriks, Anja Van De Stolpe, Stephan Voss, Axel Winkel, Marjolein Van Der Voort, Vishnu Vardhan Pully, Gerhardus Wilhelmus Lucassen, Susanne Dorien Van Den Berg-Dams, Jarich Willem Spliethoff
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Patent number: 10342416Abstract: The present invention relates to a medical probe which consists of a cannula with a multilumen stylet inside. The multilumen contains at least two lumen. Both the multilumen as well as the cannula may have beveled ends. In the lumen straight optical fibers (i.e. no angle end face) are present that can be connected at the proximal end to a console. The cannula, multilumen, fiber system forming the medical probe comprises at least in one of the lumen of the multilumen more than one optical fiber. Preferably the source and detector fibers for the fluorescence detection are contained in one single lumen of the multilumen.Type: GrantFiled: October 9, 2012Date of Patent: July 9, 2019Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Waltherus Cornelis Jozef Bierhoff, Axel Winkel, Bernardus Hendrikus Wilhelmus Hendriks, Stephan Voss, Gerhardus Wilhelmus Lucassen
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Patent number: 10143450Abstract: A biopsy device includes a tubular member, a hollow shaft and an elongated fiber body having at least one optical fiber. The hollow shaft has a laterally (sidewardly) facing notch in its distal portion. The tubular member is movable relative to the shaft, between a first position in which the notch is covered by the tubular member, and a second position in which the notch is not covered by the tubular member. The shaft is movable between a first position in which the distal end of the optical fiber is located at the distal end of the shaft with the elongated fiber body extending through the notch, and a second position in which the distal end of the at least one optical fiber is located proximally to the notch.Type: GrantFiled: October 28, 2013Date of Patent: December 4, 2018Assignee: Koninklijke Philips N.V.Inventors: Waltherus Cornelis Jozef Bierhoff, Christian Reich, Martinus Bernardus Van Der Mark, Bernardus Hendrikus Wilhelmus Hendriks, Anja Van De Stolpe, Stephan Voss, Axel Winkel, Marjolen Van Der Voort, Vishnu Vardhan Pully, Gerhardus Wilhelmus Lucassen, Susanne Dorien Van Den Berg-Dams, Jarich Willem Spliethoff
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Publication number: 20180303468Abstract: A biopsy device is provided comprising a tubular member, a hollow shaft and an elongated fiber body. The hollow shaft may have a distal end and a shaft, wherein a laterally (sidewardly) facing notch is formed in the distal portion of the shaft. The elongated fiber body may include at least one optical fiber, preferably at least two optical fibers, with a distal end. The tubular member is movable relative to the shaft, between a first position in which the notch is covered by the tubular member, and a second position in which the notch is not covered by the tubular member. The fiber body is movable within the shaft, between a first position in which the distal end of the optical fiber is located at the distal end of the shaft with the elongated fiber body extending through the notch, and a second position in which the distal end of the at least one optical fiber is located proximally to the notch.Type: ApplicationFiled: June 26, 2018Publication date: October 25, 2018Inventors: Waltherus Cornelis Jozef Bierhoff, Christian Reich, Martinus Bernardus Van Der Mark, Bernardus Hendrikus Wilhelmus Hendriks, Anja Van De Stolpe, Stephan Voss, Axel Winkel, Marjolen Van Der Voort, Vishnu Vardhan Pully, Gerhardus Wilhelmus Lucassen, Susanne Dorien Van Den Berg-Dams, Jarich Willem Spliethoff
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Patent number: 9945915Abstract: An elongate device, such as a catheter, for interventional MRI has one or more passive LC-circuits attached to its distal tip portion for position tracking. The LC-circuits includes an inductor winding and a three-dimensional “trench” capacitor. The LC-circuits are integrated in a piece of silicon. Optical fibers may be included in the device for optical probing of tissue surrounding the distal tip portion.Type: GrantFiled: April 13, 2010Date of Patent: April 17, 2018Assignee: Koninklijke Philips N.V.Inventors: Mareike Klee, Axel Winkel, John Brean Mills, Ronald Dekker, Bernardus Hendrikus Wilhelmus Hendriks
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Patent number: 9854961Abstract: The present invention relates to a medical needle which comprises an elongate tube and at least one optical fiber, e.g. two fibers, arranged within the elongate tube, for making optical measurements at the distal end of the needle. The optical fibers(s) has a beveled distal end surface, wherein a plane touching the beveled distal end surface and a longitudinal extension axis of the optical fiber forms a bevel angle which is 30°-35°. Such needle is advantageous for providing a medical needle which is reliable and long term stable, can be manufactured in low cost using known optical fiber materials, thus allowing it to form part of disposable medical kits. Still, the bevel angle of 30°-35° provides a needle which is easy to insert and which provides a low tendency to cause tissue sticking. Especially, the elongate tube and the optical fiber end(s) have the same beveled angle within the range 30°-35°, thus allowing a smooth front surface of the needle.Type: GrantFiled: April 3, 2014Date of Patent: January 2, 2018Assignee: Koninklijke Philips N.V.Inventors: Klaas Cornelis Jan Wijbrans, Gerhardus Wilhelmus Lucassen, Bernardus Hendrikus Wilhelmus Hendriks, Christian Reich, Johannes Antonius Van Rooij, Waltherus Cornelis Jozef Bierhoff, Marjolein Van Der Voort, Axel Winkel, Stephan Voss, Torre Michelle Bydlon
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Publication number: 20160007841Abstract: The present invention relates to a medical needle which comprises an elongate tube and at least one optical fiber, e.g. two fibers, arranged within the elongate tube, for making optical measurements at the distal end of the needle. The optical fibers(s) has a beveled distal end surface, wherein a plane touching the beveled distal end surface and a longitudinal extension axis of the optical fiber forms a bevel angle which is 30°-35°. Such needle is advantageous for providing a medical needle which is reliable and long term stable, can be manufactured in low cost using known optical fiber materials, thus allowing it to form part of disposable medical kits. Still, the bevel angle of 30°-35° provides a needle which is easy to insert and which provides a low tendency to cause tissue sticking. Especially, the elongate tube and the optical fiber end(s) have the same beveled angle within the range 30°-35°, thus allowing a smooth front surface of the needle.Type: ApplicationFiled: April 3, 2014Publication date: January 14, 2016Inventors: Klaas Cornelis Jan WIJBRANS, GERHARDUS WILHELMUS LUCASSEN, BERNARDUS HENDRIKUS WILHELMUS HENDRIKS, CHRISTIAN REICH, JOHANNES ANTONIUS VAN ROOIJ, WALTHERUS CORNELIS JOZEF BIERHOFF, MARJOLEIN VAN DER VOORT, AXEL WINKEL, STEPHAN VOSS, TORRE MICHELLE BYDLON
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Publication number: 20150265256Abstract: A biopsy device is provided comprising a tubular member, a hollow shaft and an elongated fiber body. The hollow shaft may have a distal end and a shaft, wherein a laterally (sidewardly) facing notch is formed in the distal portion of the shaft. The elongated fiber body may include at least one optical fiber, preferably at least two optical fibers, with a distal end. The tubular member is movable relative to the shaft, between a first position in which the notch is covered by the tubular member, and a second position in which the notch is not covered by the tubular member. The fiber body is movable within the shaft, between a first position in which the distal end of the optical fiber is located at the distal end of the shaft with the elongated fiber body extending through the notch, and a second position in which the distal end of the at least one optical fiber is located proximally to the notch.Type: ApplicationFiled: October 28, 2013Publication date: September 24, 2015Inventors: Waltherus Cornelis Jozef Bierhoff, Christian Reich, Martinus Bernardus Van Der Mark, Bernardus Hendrikus Wilhelmus Hendriks, Anja Van De Stolpe, Stephan Voss, Axel Winkel, Marjolen Van Der Voort, Vishnu Vardhan Pully, Gerhardus Wilhelmus Lucassen, Susanne Dorien Van Den Berg-Dams, Jarich Willem Spliethoff
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Publication number: 20150057530Abstract: The present invention relates to a medical needle which comprises a needle (1) having at least one channel (21), at least one optical waveguide (22) and a syringe connector (20). The syringe connector (20) is in communication with the at least one channel (21) and permits further communication with an additional syringe (25), thereby permitting the correspondence of fluid between the syringe (25) and the tip of the needle (1). The optical waveguides (22) are arranged within the needle (1) in order to make optical measurements at the tip of the needle (1). The cross section of the distal end of the elongate tube (1) has a dividing line for each channel (21) which separates that channel (21) from the one or more optical waveguides (22).Type: ApplicationFiled: March 30, 2013Publication date: February 26, 2015Inventors: Stephan Adriaan Roggeveen, Gerhardus Wilhelmus Lucassen, Marjolein Van Der Voort, Axel Winkel, Stephan Voss, Jasper Klewer, Bernardus Hendrikus Wilhelmus Hendriks, Waltherus Cornelis Jozef Bierhoff, Manfred Muller
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Publication number: 20140121538Abstract: A needle is proposed including a cannula or hollow shaft with a multilumen insert inside. The insert comprises at least two lumen. Both the insert as well as the cannula have bevelled ends. In the insert substantially straight cleaved fibers are present that may be connected at the proximal end to a console. At least one of the distal fiber ends in the insert may protrude more than half the fiber diameter out of the insert. Furthermore, the bevel angle of the insert is different from the bevel angle of the cannula such that combination cannula and insert is such that the fiber ends do not protrude the bevel surface of the cannula.Type: ApplicationFiled: June 13, 2012Publication date: May 1, 2014Applicant: KONINKLIJKE PHILIPS N.V.Inventors: Bernardus Hendrikus Wilhelmus Hendriks, Waltherus Cornelis Jozef Bierhoff, Gerhardus Wilhelmus Lucassen, Jeroen Jan Lambertus Horiks, Susanne Dorien Van Den Bergdams, Christian Reich, Stephan Voss, Axel Winkel, Rami Nachabe, Manfred Muller, Marjolein Van Der Voort
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Publication number: 20120116209Abstract: An elongate device (e.g. a catheter) for interventional MRI has one or more passive LC-circuits (wireless markers) attached to its distal tip portion for position tracking. The LC-circuits comprise an inductor winding (480) and a three-dimensional “trench” capacitor (420-440) and are integrated in a piece of silicon (410). Optical fibres may be included in the device for optical probing of tissue surrounding the distal tip portion.Type: ApplicationFiled: April 13, 2010Publication date: May 10, 2012Applicant: Koninklijke Philips Electronics N.V.Inventors: Mareike Klee, Axel Winkel, John Brean Mills, Ronald Dekker, Bernardus Hendrikus Wilhelmus Hendriks
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Patent number: 8123697Abstract: An MR-guided biopsy, for example, prostate biopsy, is performed by a mechanical tool for stabilizing the patient in prone position and for guiding the biopsy needle into defined targeted lesions in the prostate gland. The patient can lay prone in the MRI. The apparatus can guide an MR-visible, sterile needle sleeve, which can have a hollow tube filled with contrast media, through the anus onto the inner wall of the colon. Due to the visibility of the contrast media in the sleeve, the apparatus can be guided to the exact position. The sleeve can incorporate a tube within the contrast media filled sleeve to insert the biopsy needle and to push this needle forward into the prostate. The apparatus can utilize various mechanical mechanisms to stereotactically move the needle or needle sleeve in various directions.Type: GrantFiled: December 22, 2008Date of Patent: February 28, 2012Assignee: Koninklijke Philips Electronics N.V.Inventors: Wolfgang R. Daum, Axel Winkel
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Publication number: 20090247859Abstract: The subject invention pertains to a method and apparatus for MR-guided biopsy. The subject invention can be applied to, for example, prostate biopsy. In a specific embodiment, the subject invention can provide a mechanical tool for stabilizing the patient in prone position and to guide a biopsy needle into defined targeted lesions in the prostate gland. The patient can lay prone in the MRI. The subject apparatus can guide an MR-visible, sterile needle sleeve, which can have a hollow tube filled with contrast media, through the anus onto the inner wall of the colon. Due to the visibility of the contrast media in the sleeve, the apparatus can be guided to the exact position. The sleeve can incorporate a tube within the contrast media filled sleeve to insert the biopsy needle and to push this needle forward into the prostate. The subject apparatus can utilize various mechanical means to stereotactically move the needle or needle sleeve in various directions.Type: ApplicationFiled: December 22, 2008Publication date: October 1, 2009Inventors: Wolfgang R. Daum, Axel Winkel
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Publication number: 20080177268Abstract: The subject invention pertains to a method and apparatus for placing a minimally-invasive access with respect to a patient's bone or other non-soft tissue. The subject invention can use a drilling machine incorporating an ultrasound motor. The subject drilling machine can be applied to sample, for example, bone biopsies under MRI control. In a specific embodiment, the subject ultrasound motor can be completely manufactured of non-magnetic materials, such as plastics, titanium, and titanium alloy, or ceramics and piezoceramics. The subject drilling apparatus can be placed into an MRI near field without influencing the image quality, and without the drilling apparatus itself being disturbed by the MRI magnet, gradient, or high-frequency field. The subject invention can incorporate good shielding with the subject drilling apparatus use of these materials, and can achieve minimal, if any, image distortions or so-called artifacts.Type: ApplicationFiled: February 21, 2008Publication date: July 24, 2008Inventors: Wolfgang Daum, Axel Winkel, Thomas Gunther, Andreas Klink
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Publication number: 20060276876Abstract: The subject invention pertains instruments for use in nuclear spin tomography comprising a metal alloy comprising aluminum, vanadium, and titanium. In a specific embodiment, the subject invention relates to cardiovascular stents which can exhibit a low incidence of artifacts and are viewable in a nuclear spin tomography unit. The subject invention also pertains to a method for processing instruments for use in nuclear spin tomography. Spin processing can comprise application of a wet chemical etching solution. In a specific embodiment, the wet chemical etching solution can comprise three parts hydrochloric acid and two parts saltpeter acid.Type: ApplicationFiled: March 31, 2006Publication date: December 7, 2006Inventors: Wolfgang Daum, Axel Winkel
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Publication number: 20060122630Abstract: The subject invention pertains to a device for inserting medical instruments into the human body. In a specific embodiment, the subject device can be made from a material which is invisible under Magnetic Resonance Imaging (MRI). The subject device can incorporate three or more MRI compatible marks. The imaging of these three or more markers can allow the determination of the orientation of the device. A virtual image of the device can then be shown in an MRI image.Type: ApplicationFiled: January 23, 2006Publication date: June 8, 2006Inventors: Wolfgang Daum, Axel Winkel
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Patent number: 6989015Abstract: The subject invention pertains to a device for inserting medical instruments into the human body. In a specific embodiment, the subject device can be made from a material which is invisible under Magnetic Resonance Imaging (MRI). The subject device can incorporate three or more MRI compatible marks. The imaging of these three or more markers can allow the determination of the orientation of the device. A virtual image of the device can then be shown in an MRI image.Type: GrantFiled: August 1, 2003Date of Patent: January 24, 2006Assignee: Invivo Germany GmbHInventors: Wolfgang Daum, Axel Winkel
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Publication number: 20050143650Abstract: The subject invention pertains to a tissue marker. The subject invention also relates to methods and apparatus for deploying a tissue marker. In a specific embodiment, the subject marker is magnetic resonance imaging (MRI) compatible. In additional embodiment, various components of the subject marker deploying apparatus are MRI compatible. A specific marker in accordance with the subject invention is flexible such that the marker has an equilibrium shape, which the marker will have when deployed in tissue to be marked, and an elongated shape, which the marker can be bent into to be inserted into a marker needle.Type: ApplicationFiled: November 24, 2004Publication date: June 30, 2005Inventor: Axel Winkel
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Publication number: 20040211491Abstract: The subject invention relates to a stent with respect to which the occurrence of artifacts in nuclear spin tomography can be reduced or avoided. The subject invention also pertains to the etching of stents, incorporating titanium and/or titanium alloys, that have been processed with tools containing magnetizing components. The subject invention can also be useful for the control of in-stent-restenosis by allowing imaging under nuclear spin tomography to see in-stent-restenosis in the interior of the subject stent.Type: ApplicationFiled: May 21, 2004Publication date: October 28, 2004Inventors: Wolfgang Daum, Axel Winkel
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Patent number: 6780338Abstract: The subject invention pertains instruments for use in nuclear spin tomography comprising a metal alloy comprising aluminum, vanadium, and titanium. In a specific embodiment, the subject invention relates to cardiovascular stents which can exhibit a low incidence of artifacts and are viewable in a nuclear spin tomography unit. The subject invention also pertains to a method for processing instruments for use in nuclear spin tomography. Such processing can comprise application of a wet chemical etching solution. In a specific embodiment, the wet chemical etching solution can comprise three parts hydrochloric acid and two parts saltpeter acid.Type: GrantFiled: March 5, 2002Date of Patent: August 24, 2004Assignee: MRI Devices Daum GmbHInventors: Wolfgang Daum, Axel Winkel