Patents by Inventor Axel Zeeck

Axel Zeeck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Macrolides and the use thereof
    Patent number: 5610178
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydroxy, 2-hydroxyethoxy, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkanoyloxy, halogen, amino, azido, a keto, p-nitrobenzenesulfonyl or a pyranyloxy group of the formula ##STR2## wherein X is a group of the formula ##STR3## wherein R.sub.3 is hydroxy, C.sub.1 -C.sub.4 alkanoyloxy or organic sulfonyloxy, andR.sub.4 is hydroxy or carbamoyloxy,R.sub.2 is hydrogen, hydroperoxy, hydroxy or methoxy,Y is a group of the formula ##STR4## wherein R.sub.5 is hydroxy or C.sub.1 -C.sub.4 alkanoyloxy, andR.sub.6 and R.sub.7 each independently of the other is hydrogen or methyl, are suitable for the preparation of a medicament for the prophylaxis and treatment of diseases that respond to the inhibition of the osteoclast proton pump.
    Type: Grant
    Filed: August 9, 1994
    Date of Patent: March 11, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Axel Zeeck, Kai U. Bindseil, Claudia Boddien
  • Penicillium cultures capable of producing 10-membered ring lactones
    Patent number: 5561060
    Abstract: Penicillium cultures capable of producing 10-member ring lactones.It is possible with the aid of Penicillium strains to prepare new 10-membered ring lactones having a pharmacological action.
    Type: Grant
    Filed: April 12, 1995
    Date of Patent: October 1, 1996
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Joachim Wink, Susanne Grabley, Gerhard Seibert, Klaus Hutter, Axel Zeeck
  • Process for the production of furans and lactones from streptomyces
    Patent number: 5252472
    Abstract: It is possible with the aid of various Streptomycetes species to prepare new compounds having a furan or lactone structure. These compounds have a pharmacological, especially antibiotic, action.
    Type: Grant
    Filed: February 7, 1992
    Date of Patent: October 12, 1993
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Susanne Grabley, Joachim Wink, Klaus Kuhlein, Gerhard Seibert, Klaus Hutter, Hermann Uhr, Axel Zeeck
  • Oasomycins
    Patent number: 5189150
    Abstract: Novel macrolactones with pharmacological effects can be prepared with the aid of Streptoverticillium and Streptomycetes strains.
    Type: Grant
    Filed: October 24, 1991
    Date of Patent: February 23, 1993
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Axel Zeeck, Siegrid Philipps, Susanne Grabley, Ernold Granzer, Klaus Hutter, Ralf Thiericke, Joachim Wink
  • Furans and lactones from sterptomycetes and the use thereof
    Patent number: 5128370
    Abstract: New furans and lactones from streptomycetes, a process for the preparation thereof, and the use thereof.It is possible with the aid of various streptomycetes species to prepared new compounds having a furan or lactone structure. These compounds have a pharmacological, especially antibiotic, action.
    Type: Grant
    Filed: March 20, 1989
    Date of Patent: July 7, 1992
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Susanne Grabley, Joachim Wink, Klaus Kuhlein, Gerhard Seibert, Klaus Hutter, Hermann Uhr, Axel Zeeck
  • Streptenols from streptomycetes, and the preparation and use thereof
    Patent number: 5118882
    Abstract: Novel streptenols with pharmacological activity, in particular with HMG-CoA-reductase inhibiting activity, can be isolated from the nutrient broth of streptomycetes. These compounds can also be used as synthesis unit for the production of mevilonin analogues.
    Type: Grant
    Filed: February 22, 1990
    Date of Patent: June 2, 1992
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Axel Zeeck, Susanne Grabley, Joachim Wink, Peter Hammann, Carlo Giani, Pia Kricke-Helling
  • Angucyclinones from Streptomycetes, a process for the preparation thereof, and the use thereof
    Patent number: 5100921
    Abstract: New angucyclinones with a therapeutic action can be prepared with the aid of a strain of the genus Streptomyces.
    Type: Grant
    Filed: April 25, 1989
    Date of Patent: March 31, 1992
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Susanne Grabley, Joachim Wink, Carlo Giani, Gerhard Seibert, Wolfgang Raether, Susanne Dobreff, Axel Zeeck
  • 10-membered ring lactones, a process for the preparation thereof, and the use thereof
    Patent number: 5089521
    Abstract: New 10-membered ring lactones, a process for the preparation thereof, and the use thereof.It is possible with the aid of Penicillium strains to prepare new 10-membered ring lactones having a pharmacological action.
    Type: Grant
    Filed: August 3, 1990
    Date of Patent: February 18, 1992
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Joachim Wink, Susanne Grabley, Gerhard Seibert, Klaus Hutter, Axel Zeeck
  • Manumycin derivatives and the use thereof
    Patent number: 5079263
    Abstract: R.sup.2 is H or OH;R.sup.3 is H, OH, OCH.sub.3, CH.sub.3 or NH.sub.2 ;Rhu 4 is H, OH, OCH.sub.3, NH.sub.2 or ##STR2## The compounds of the formula I are prepared by fermentation of the strain Streptomyces parvulus DSM 40722 in the presence of substituted benzoic acids of the general formula II ##STR3## where R.sup.1 is H or OH;R.sup.2 is H or OH;R.sup.3 is H, OH, OCH.sub.3, CH.sub.3 or NH.sub.2 ;R.sup.4 is H, OH, OCH.sub.3 or NH.sub.2,and they inhibit Leukocyte elastase and can be used as pharmaceuticals.
    Type: Grant
    Filed: December 2, 1988
    Date of Patent: January 7, 1992
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Axel Zeeck, Ralf Thiericke, Hans Zahner, Gerhard Dickneite, Hans H. Sedlacek
  • Angucyclinones from streptomycetes, a process for the preparation thereof, and the use thereof
    Patent number: 4945108
    Abstract: New angucyclinones with a therapeutic action can be prepared with the aid of a strain of the genus Streptomyces.
    Type: Grant
    Filed: April 24, 1989
    Date of Patent: July 31, 1990
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Susanne Grabley, Joachim Wink, Carlo Giani, Gerhard Seibert, Wolfgang Raether, Susanne Dobreff, Axel Zeeck
  • Acyl derivatives of urdamycin A, their preparation and their use
    Patent number: 4939125
    Abstract: The O-acyl derivatives of urdamycin A exhibit an antibiotic or antitumoral activity.
    Type: Grant
    Filed: October 5, 1987
    Date of Patent: July 3, 1990
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Axel Zeeck, Thomas Ciesiolka, Hans Zahner, Hannelore Drautz
  • Gentisic acid derivatives having antibiotic activity
    Patent number: 4861796
    Abstract: 2-Acetylaminogentisic acid has been isolated from the culture broth after cultivation of a bacterium of the genus Streptomyces. This compound has antibacterial actions against Gram-positive and Gram-negative bacteria.
    Type: Grant
    Filed: December 19, 1988
    Date of Patent: August 29, 1989
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Axel Zeeck, Sabine Breiding-Mack, Susanne Grabley, Hartmut Voelskow, Gerhard Seibert
  • Pharmacological use of phenoxazinones
    Patent number: 4861775
    Abstract: Streptomyces spec. DSM 3813 produces novel compounds with a basic phenoxazinone structure, which have an antifungal and antiviral action and can be used as lipoxygenase inhibitors.
    Type: Grant
    Filed: August 25, 1987
    Date of Patent: August 29, 1989
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Axel Zeeck, Sabine Breiding-Mack, Susanne Grabley, Hartmut Voelskow, Gerhard Seibert
  • Urdamycin G and derivatives thereof, a process for their preparation and their use
    Patent number: 4859655
    Abstract: A new substance, urdamycin G, has been found which, like its O-acyl derivatives, exhibits an antibiotic or antitumoral activity.
    Type: Grant
    Filed: August 26, 1987
    Date of Patent: August 22, 1989
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Axel Zeeck, Thomas Ciesiolka, Jurgen Rohr, Hans Zahner, Hannelore Drautz