Patents by Inventor Aya Jakobovits

Aya Jakobovits has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NUCLEIC ACIDS AND CORRESPONDING PROTEINS ENTITLED 58P1D12 USEFUL IN TREATMENT AND DETECTION OF CANCER
    Publication number: 20110008393
    Abstract: A novel gene 58P1D12 and its encoded protein, and variants thereof, are described wherein 58P1D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 58P1D12 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 58P1D12 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 58P1D12 can be used in active or passive immunization.
    Type: Application
    Filed: July 14, 2010
    Publication date: January 13, 2011
    Inventors: Steven B. KANNER, Aya Jakobovits, Pia M. Challita-Eid, Wangmao Ge, Arthur B. Raitano
  • ANTIBODY DRUG CONJUGATES (ADC) THAT BIND TO 24P4C12 PROTEINS
    Publication number: 20100330107
    Abstract: Antibody drug conjugates (ADC's) that bind to 24P4C12 protein and variants thereof are described herein. 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
    Type: Application
    Filed: March 5, 2010
    Publication date: December 30, 2010
    Applicants: AGENSYS, INC., SEATTLE GENETICS
    Inventors: Jean Gudas, Aya Jakobovits, Zili An, Robert Kendall Morrison, Karen Jane Meyrick Morrison, Xiao-chi Jia, Dennis Benjamin, Ruth Moser, Peter Senter
  • Antibodies to tumor associated proteins
    Patent number: 7858750
    Abstract: A novel gene 024P4C12 (also designated 24P4C12) and its encoded protein, and variants thereof, are described wherein 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 24P4C12 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 24P4C12 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 24P4C12 can be used in active or passive immunization.
    Type: Grant
    Filed: August 20, 2007
    Date of Patent: December 28, 2010
    Assignee: Agensys, Inc.
    Inventors: Arthur B. Raitano, Karen Jane Meyrick Morrison, Wangmao Ge, Pia M. Challita-Eid, Aya Jakobovits
  • DIAGNOSIS AND THERAPY OF CANCER USING SGP28-RELATED MOLECULES
    Publication number: 20100316994
    Abstract: The present invention relates to methods and compositions for the diagnosis and therapy of prostate cancer which utilize isolated polynucleotides corresponding to the human SGP28 gene, proteins encoded by the SGP28 gene and fragments thereof, and antibodies capable of specifically recognizing and binding to SGP28 proteins.
    Type: Application
    Filed: December 23, 2008
    Publication date: December 16, 2010
    Inventors: Rene S. Hubert, Arthur B. Raitano, Daniel E. H. Afar, Steve Chappell Mitchell, Mary Faris, Aya Jakobovits
  • HUMAN MONOCLONAL ANTIBODIES TO EPIDERMAL GROWTH FACTOR RECEPTOR
    Publication number: 20100305307
    Abstract: In accordance with the present invention, there are provided fully human monoclonal antibodies against human epidermal growth factor receptor (EGF-r). Nucleotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences from CDR1 through CDR3, are provided. Hybridomas expressing such immunoglobulin molecules and monoclonal antibodies are also provided.
    Type: Application
    Filed: April 26, 2010
    Publication date: December 2, 2010
    Inventors: Aya Jakobovits, Xiao-Dong Yang, Michael Gallo, Xiao-Chi Jia
  • Nucleic acids and corresponding proteins entitled 58P1D12 useful in treatment and detection of cancer
    Patent number: 7842458
    Abstract: A novel gene 58P1D12 and its encoded protein, and variants thereof, are described wherein 58P1D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 58P1D12 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 58P1D12 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 58P1D12 can be used in active or passive immunization.
    Type: Grant
    Filed: August 16, 2004
    Date of Patent: November 30, 2010
    Assignee: Agensys, Inc.
    Inventors: Steven B. Kanner, Aya Jakobovits, Pia M. Challita-Eid, Wangmao Ge, Arthur B. Raitano
  • NUCLEIC ACIDS AND CORRESPONDING PROTEIN ENTITLED 125P5C8 USEFUL IN TREATMENT AND DETECTION OF CANCER
    Publication number: 20100297005
    Abstract: A novel gene 191P4D12(b) and its encoded protein, and variants thereof, are described wherein 191P4D12(b) exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 191P4D12(b) provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 191P4D12(b) gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 191P4D12(b) can be used in active or passive immunization.
    Type: Application
    Filed: June 22, 2010
    Publication date: November 25, 2010
    Applicant: Agensys, Inc.
    Inventors: Arthur B. RAITANO, Pia M. Challita-Eid, Aya Jakobovits, Mary Faris, Wangmao Ge
  • NUCLEIC ACIDS AND CORRESPONDING PROTEINS ENTITLED 191P4D12(b) USEFUL IN TREATMENT AND DETECTION OF CANCER
    Publication number: 20100297669
    Abstract: A novel gene 191P4D12(b) and its encoded protein, and variants thereof, are described wherein 191P4D12(b) exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 191P4D12(b) provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 191P4D12(b) gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 191P4D12(b) can be used in active or passive immunization.
    Type: Application
    Filed: June 22, 2010
    Publication date: November 25, 2010
    Applicant: Agensys, Inc.
    Inventors: Arthur B. RAITANO, Pia M. Challita-Eid, Aya Jakobovits, Mary Faris, Wangmao Ge
  • NUCLEIC ACID AND CORRESPONDING PROTEIN ENTITLED 193P1E1B USEFUL IN TREATMENT AND DETECTION OF CANCER
    Publication number: 20100297650
    Abstract: A novel gene 0193P1E1B (also designated 193P1E1B) and its encoded protein, and variants thereof, are described wherein 193P1E1B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 193P1E1B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 193P1E1B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 193P1E1B can be used in active or passive immunization.
    Type: Application
    Filed: April 20, 2010
    Publication date: November 25, 2010
    Applicant: AGENSYS, INC.
    Inventors: ARTHUR B. RAITANO, PIA M. CHALLITA-EID, MARY FARIS, RENE S. HUBERT, WANGMAO GE, AYA JAKOBOVITS
  • NUCLEIC ACIDS AND CORRESPONDING PROTEINS ENTITLED 191P4D12(b) USEFUL IN TREATMENT AND DETECTION OF CANCER
    Publication number: 20100297006
    Abstract: A novel gene 191P4D12(b) and its encoded protein, and variants thereof, are described wherein 191P4D12(b) exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 191P4D12(b) provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 191P4D12(b) gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 191P4D12(b) can be used in active or passive immunization.
    Type: Application
    Filed: June 22, 2010
    Publication date: November 25, 2010
    Applicant: Agensys, Inc.
    Inventors: Arthur B. RAITANO, Pia M. Challita-Eid, Aya Jakobovits, Mary Faris, Wangmao Ge
  • NUCLEIC ACID ENCODING 238P1B2 USEFUL IN DETECTING CANCER
    Publication number: 20100291094
    Abstract: A novel gene (designated 238P1B2) and its encoded protein, and variants thereof, are described wherein 238P1B2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 238P1B2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 238P1B2 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 238P1B2 can be used in active or passive immunization.
    Type: Application
    Filed: May 21, 2010
    Publication date: November 18, 2010
    Applicant: AGENSYS, INC.
    Inventors: ARTHUR B. RAITANO, PIA M. CHALLITA-EID, MARY FARIS, RENE S. HUBERT, ROBERT KENDALL MORRISON, WANGMAO GE, AYA JAKOBOVITS
  • PROTEIN SHOWING ENHANCED EXPRESSION IN CANCER CELLS
    Publication number: 20100291126
    Abstract: A novel gene (designated 101P3A11 or PHOR-1) and its encoded protein, and variants thereof, are described wherein 101P3A11 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 101P3A11 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 101P3A11 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 101P3A11 can be used in active or passive immunization.
    Type: Application
    Filed: July 23, 2010
    Publication date: November 18, 2010
    Applicant: AGENSYS, INC.
    Inventors: AYA JAKOBOVITS, MARY FARIS, ARTHUR B. RAITANO, ROBERT KENDALL MORRISON, DOUGLAS SAFFRAN, WANGMAO GE, PIA M. CHALLITA-EID
  • 125P5C8: tissue specific protein highly expressed in various cancers
    Patent number: 7834156
    Abstract: A novel gene (designated 125P5C8) and its encoded protein are described. While 125P5C8 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed multiple cancers including prostate, bladder, kidney and colon cancers. Consequently, 125P5C8 provides a diagnostic and/or therapeutic target for cancers, and the 125P5C8 gene or fragment thereof, or its encoded protein or a fragment thereof used to elicit an immune response.
    Type: Grant
    Filed: September 18, 2007
    Date of Patent: November 16, 2010
    Assignee: Agensys, Inc.
    Inventors: Mary Faris, Pia M. Challita-Eid, Steve Chappell Mitchell, Daniel E. H. Afar, Arthur B. Raitano, Aya Jakobovits
  • ANTIBODIES TO TUMOR ASSOCIATED PROTEINS
    Publication number: 20100273174
    Abstract: A novel gene 024P4C12 (also designated 24P4C12) and its encoded protein, and variants thereof, are described wherein 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 24P4C12 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 24P4C12 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 24P4C12 can be used in active or passive immunization.
    Type: Application
    Filed: July 1, 2010
    Publication date: October 28, 2010
    Inventors: Arthur B. RAITANO, Karen Jane Meyrick Morrison, Wangmao Ge, Pia M. Challita-Eid, Aya Jakobovits
  • Transgenic mammals having human IG loci including plural Vand Vregions and antibodies produced therefrom
    Patent number: 7820877
    Abstract: The present invention relates to transgenic non-human animals that are engineered to contain human immunoglobulin gene loci. In particular, animals in accordance with the invention possess human Ig loci that include plural variable (VH and V?) gene regions. Advantageously, the inclusion of plural variable region genes enhances the specificity and diversity of human antibodies produced by the animal. Further, the inclusion of such regions enhances and reconstitutes B-cell development to the animals, such that the animals possess abundant mature B-cells secreting extremely high affinity antibodies.
    Type: Grant
    Filed: October 14, 2005
    Date of Patent: October 26, 2010
    Assignee: Amgen Fremont Inc.
    Inventors: Aya Jakobovits, Raju Kucherlapati, Sue Klapholz, Michael J. Mendez, Larry Green
  • NUCLEIC ACID AND CORRESPONDING PROTEIN ENTITLED 125P5C8 USEFUL IN TREATMENT AND DETECTION OF CANCER
    Publication number: 20100266498
    Abstract: A novel gene (designated 125P5C8) and its encoded protein, and variants thereof, are described wherein 125P5C8 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 125P5C8 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 125P5C8 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 125P5C8 can be used in active or passive immunization.
    Type: Application
    Filed: June 21, 2010
    Publication date: October 21, 2010
    Applicant: Agensys, Inc.
    Inventors: Mary FARIS, Pia M. Challita-Eid, Rene S. Hubert, Daniel E. H. Afar, Arthur B. Raitano, Wangmao Ge, Robert Kendall Morrison, Karen Jane Meyrick Morrison, Aya Jakobovits
  • ANTIBODIES AND RELATED MOLECULES THAT BIND TO 161P2F10B PROTEINS
    Publication number: 20100260756
    Abstract: Antibodies and molecules derived therefrom that bind to 161P2F10B protein and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P2F10B can be used in active or passive immunization.
    Type: Application
    Filed: April 9, 2010
    Publication date: October 14, 2010
    Inventors: Aya Jakobovits, Steven B. Kanner, Pia M. Challita-Eid, Juan J. Perez-Villar, Daulet Satpaev, Arthur B. Raitano, Robert Kendall Morrison, Karen Jane Meyrick Morrison, Xiao-chi Jia, Jean Gudas
  • Nucleic acids and corresponding proteins entitled 158P3D2 useful in treatment and detection of cancer
    Patent number: 7811575
    Abstract: A novel gene 158P3D2 and its encoded protein, and variants thereof, are described wherein 158P3D2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 158P3D2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 158P3D2 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 158P3D2 can be used in active or passive immunization.
    Type: Grant
    Filed: November 19, 2004
    Date of Patent: October 12, 2010
    Assignee: Agensys, Inc.
    Inventors: Arthur B. Raitano, Aya Jakobovits, Pia M. Challita-Eid, Steven B. Kanner, Wangmao Ge, Juan J. Perez-Villar, Robert Kendall Morrison
  • Antibodies and related molecules that bind to 161P2F10B proteins
    Patent number: 7811565
    Abstract: Antibodies and molecules derived therefrom that bind to 161P2F10B protein and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P2F10B can be used in active or passive immunization.
    Type: Grant
    Filed: April 30, 2009
    Date of Patent: October 12, 2010
    Assignee: Agensys, Inc.
    Inventors: Aya Jakobovits, Steven B. Kanner, Pia M. Challita-Eid, Juan J. Perez-Villar, Daulet Satpaev, Arthur B. Raitano, Robert Kendall Morrison, Karen Jane Meyrick Morrison, Xiao-chi Jia, Jean Gudas
  • NOVEL GENE UPREGULATED IN CANCERS OF THE PROSTATE
    Publication number: 20100255535
    Abstract: The present invention relates to a novel protein designated 20P2H8 which shares homology with several heterogeneous nuclear ribonucleoproteins (hnRNPs). A full length approximately 3600 by 20P2H8 cDNA (SEQ ID NO: 1, encoding a 517 amino acid open reading frame (SEQ ID NO: 2), is provided herein.
    Type: Application
    Filed: June 16, 2010
    Publication date: October 7, 2010
    Applicant: Agensys, Inc.
    Inventors: Daniel E.H. AFAR, Arthur B. Raitano, Rene S. Hubert, Steve Chappell Mitchell, Aya Jakobovits