Patents by Inventor Aya Koide
Aya Koide has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9051437Abstract: The purpose of the present invention is to provide an electrostatically bonded vesicle which bears disulfide bonds or thiol groups. The present invention relates to a vesicle having a membrane which is formed from both a first polymer of (a) or (b) and a second polymer of (c) or (d) (with the proviso that a combination of (b) and (d) is excepted) and in which the cationic segment and anionic segment of the polymers are partially crosslinked. First polymer: (a) a block copolymer (I) having both an electrically non-charged hydrophilic segment and a cationic segment, (b) an amino acid polymer (I) having a cationic segment. Second polymer: (c) a block copolymer (II) having both an electrically non-charged hydrophilic segment and an anionic segment, (d) an amino acid polymer (II) having an anionic segment.Type: GrantFiled: July 27, 2011Date of Patent: June 9, 2015Assignees: THE UNIVERSITY OF TOKYO, TEIJIN LIMITEDInventors: Akihiro Kishimura, Kazunori Kataoka, Stephanie Lee, Yasutaka Anraku, Aya Koide, Mitsuru Sakai, QiuMing Yu
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Publication number: 20130122103Abstract: The purpose of the present invention is to provide an electrostatically bonded vesicle which bears disulfide bonds or thiol groups. The present invention relates to a vesicle having a membrane which is formed from both a first polymer of (a) or (b) and a second polymer of (c) or (d) (with the proviso that a combination of (b) and (d) is excepted) and in which the cationic segment and anionic segment of the polymers are partially crosslinked. First polymer: (a) a block copolymer (I) having both an electrically non-charged hydrophilic segment and a cationic segment, (b) an amino acid polymer (I) having a cationic segment. Second polymer: (c) a block copolymer (II) having both an electrically non-charged hydrophilic segment and an anionic segment, (d) an amino acid polymer (II) having an anionic segment.Type: ApplicationFiled: July 27, 2011Publication date: May 16, 2013Applicants: TEIJIN LIMITED, THE UNIVERSITY OF TOKYOInventors: Akihiro Kishimura, Kazunori Kataoka, Stephanie Lee, Yasutaka Anraku, Aya Koide, Mitsuru Sakai, QiuMing Yu
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Patent number: 8304497Abstract: The present invention discloses a vesicle which is excellent in structure stability and environmental responsiveness and also can be produced by a simple operation. More particularly, the present invention discloses a vesicle comprising a membrane formed of a first block copolymer containing a non-chargeable hydrophilic segment and a chargeable segment, and a second block copolymer containing a non-chargeable hydrophilic segment and a chargeable segment having an electric charge which is opposite to that of the chargeable segment of the first block copolymer.Type: GrantFiled: April 28, 2006Date of Patent: November 6, 2012Assignee: The University of TokyoInventors: Kazunori Kataoka, Aya Koide, Kensuke Osada, Yuichi Yamasaki, Shigeto Fukushima, Joon-Sik Park
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Patent number: 8076480Abstract: Disclosed is a process of preparing an optically active allyl compound, e.g., as represented by formula (III): comprising asymmetrically coupling an allyl compound with an organic nucleophilic compound in the presence of a catalyst. The catalyst is preferably a transition metal complex compound having a phosphine ligand. The phosphine ligand is preferably a 2,3-bis(dialkylphosphino)pyrazine derivative. The pyrazine derivative is preferably a quinoxaline derivative. The transition metal is preferably palladium.Type: GrantFiled: July 24, 2008Date of Patent: December 13, 2011Assignees: National University Corporation Chiba University, Nippon Chemical Industrial Co., Ltd.Inventors: Tsuneo Imamoto, Kazuhiro Yoshida, Miwako Nishimura, Aya Koide
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Patent number: 7649117Abstract: Disclosed is a process of preparing an optically active ?-hydroxycarboxylic acid derivative comprising asymmetrically hydrogenating a ?-keto compound in the presence of a catalyst comprising a transition metal complex compound having a 2,3-bis(dialkylphosphino)pyrazine derivative as a ligand. The pyrazine derivative is preferably a quinoxaline derivative, and the transition metal is preferably ruthenium. Preferred examples of the quinoxaline derivative are (S,S)-2,3-bis(tert-butylmethylphosphino)quinoxaline, (R,R)-bis(tert-butylmethylphosphino)quinoxaline, (S,S)-bis(tert-adamantylmethylphosphino)quinoxaline, and (R,R)-bis(adamantylmethylphosphino)quinoxaline.Type: GrantFiled: July 24, 2008Date of Patent: January 19, 2010Assignees: National University Corporation Chiba University, Nippon Chemical Industrial Co., Ltd.Inventors: Tsuneo Imamoto, Kazuhiro Yoshida, Miwako Nishimura, Aya Koide
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Patent number: 7534920Abstract: An optically-active bis(alkynylphosphino)ethane-borane derivative represented by formula (1): wherein R1 and R2, which may be the same or different, each represent an alkyl group, a phenyl group, an alkylsilyl group or a hydrogen atom; R3 represents a branched alkyl group, an alicyclic hydrocarbon group or an aromatic hydrocarbon group; and the asterisk * indicates an optically-active site. The derivative (1) is prepared by bromination of, e.g., an (S)-t-butylmethylphosphine-borane, reaction with an alkynyl lithium, deprotonation, followed by oxidative coupling. Deprotection of the derivative (1) by deboranation gives an optically-active bis(alkynylphosphino)ethane derivative useful as a ligand providing an asymmetric catalyst for catalytic asymmetric synthesis. The asymmetric catalyst having the ligand exhibits high selectivity and catalyst activity.Type: GrantFiled: March 5, 2008Date of Patent: May 19, 2009Assignees: Nippon Chemical Industrial Co., Ltd., National University Corporation Chiba UniversityInventors: Tsuneo Imamoto, Kazuhiro Yoshida, Youichi Saitoh, Aya Koide
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Publication number: 20090081458Abstract: The present invention discloses a vesicle which is excellent in structure stability and environmental responsiveness and also can be produced by a simple operation. More particularly, the present invention discloses a vesicle comprising a membrane formed of a first block copolymer containing a non-chargeable hydrophilic segment and a chargeable segment, and a second block copolymer containing a non-chargeable hydrophilic segment and a chargeable segment having an electric charge which is opposite to that of the chargeable segment of the first block copolymer.Type: ApplicationFiled: April 28, 2006Publication date: March 26, 2009Inventors: Kazunori Kataoka, Aya Koide, Kensuke Osada, Yuichi Yamasaki, Shigeto Fukushima, Joon-Sik Park
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Publication number: 20090030200Abstract: Disclosed is a process of preparing an optically active allyl compound comprising asymmetrically coupling an allyl compound with an organic nucleophilic compound in the presence of a catalyst. The catalyst is preferably a transition metal complex compound having a phosphine ligand. The phosphine ligand is preferably a 2,3-bis(dialkylphosphino)pyrazine derivative. The pyrazine derivative is preferably a quinoxaline derivative. The transition metal is preferably palladium.Type: ApplicationFiled: July 24, 2008Publication date: January 29, 2009Applicants: NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY, NIPPON CHEMICAL INDUSTRIAL CO., LTD.Inventors: Tsuneo IMAMOTO, Kazuhiro YOSHIDA, Miwako NISHIMURA, Aya KOIDE
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Publication number: 20090030231Abstract: Disclosed is a process of preparing an optically active ?-hydroxycarboxylic acid derivative comprising asymmetrically hydrogenating a ?-keto compound in the presence of a catalyst comprising a transition metal complex compound having a 2,3-bis(dialkylphosphino)pyrazine derivative as a ligand. The pyrazine derivative is preferably a quinoxaline derivative, and the transition metal is preferably ruthenium. Preferred examples of the quinoxaline derivative are (S,S)-2,3-bis(tert-butylmethylphosphino)quinoxaline, (R,R)-bis(tert-butylmethylphosphino)quinoxaline, (S,S)-bis(tert-adamantylmethylphosphino)quinoxaline, and (R,R)-bis(adamantylmethylphosphino)quinoxaline.Type: ApplicationFiled: July 24, 2008Publication date: January 29, 2009Applicants: NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY, NIPPON CHEMICAL INDUSTRIAL CO., LTD.Inventors: Tsuneo IMAMOTO, Kazuhiro YOSHIDA, Miwako NISHIMURA, Aya KOIDE
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Publication number: 20080221362Abstract: An optically-active bis(alkynylphosphino)ethane-borane derivative represented by formula (1): wherein R1 and R2, which may be the same or different, each represent an alkyl group, a phenyl group, an alkylsilyl group or a hydrogen atom; R3 represents a branched alkyl group, an alicyclic hydrocarbon group or an aromatic hydrocarbon group; and the asterisk * indicates an optically-active site. The derivative (1) is prepared by bromination of, e.g., an (S)-t-butylmethylphosphine-borane, reaction with an alkynyl lithium, deprotonation, followed by oxidative coupling. Deprotection of the derivative (1) by deboranation gives an optically-active bis(alkynylphosphino)ethane derivative useful as a ligand providing an asymmetric catalyst for catalytic asymmetric synthesis. The asymmetric catalyst having the ligand exhibits high selectivity and catalyst activity.Type: ApplicationFiled: March 5, 2008Publication date: September 11, 2008Applicants: Nippon Chemical Industrial Co., Ltd., National University Corporation Chiba UniversityInventors: Tsuneo Imamoto, Kazuhiro Yoshida, Youichi Saitoh, Aya Koide