Patents by Inventor Aya Konishi
Aya Konishi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9891210Abstract: This blood analyzer includes a sample preparation portion preparing a measurement sample free from a labeling substance from a blood sample and a hemolytic agent free from a labeling substance, a light information generation portion generating fluorescent information and at least two types of scattered light information from the measurement sample and a control portion performing a first classification of white blood cells in the measurement sample into at least four groups of monocytes, neutrophils, eosinophils and others on the basis of the fluorescent information and the two types of scattered light information.Type: GrantFiled: July 8, 2014Date of Patent: February 13, 2018Assignee: SYSMEX CORPORATIONInventors: Hideaki Matsumoto, Kinya Uchihashi, Yuji Itose, Aya Konishi
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Patent number: 9328375Abstract: This blood analyzer includes a sample preparation portion preparing a first measurement sample containing a blood sample and a hemolytic agent and a second measurement sample containing the blood sample, the same hemolytic agent as the hemolytic agent and a staining agent and a control portion classifying white blood cells in the first measurement sample into at least four groups of monocytes, neutrophils, eosinophils and others on the basis of fluorescent information and two types of scattered light information generated by a light information generation portion and classifying blood cells in the second measurement sample into at least malaria-infected red blood cells and others on the basis of fluorescent information and scattered light information generated by the light information generation portion.Type: GrantFiled: November 3, 2014Date of Patent: May 3, 2016Assignee: SYSMEX CORPORATIONInventors: Hideaki Matsumoto, Kinya Uchihashi, Yuji Itose, Aya Konishi, Ayumu Yoshida
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Publication number: 20150050643Abstract: This blood analyzer includes a sample preparation portion preparing a first measurement sample containing a blood sample and a hemolytic agent and a second measurement sample containing the blood sample, the same hemolytic agent as the hemolytic agent and a staining agent and a control portion classifying white blood cells in the first measurement sample into at least four groups of monocytes, neutrophils, eosinophils and others on the basis of fluorescent information and two types of scattered light information generated by a light information generation portion and classifying blood cells in the second measurement sample into at least malaria-infected red blood cells and others on the basis of fluorescent information and scattered light information generated by the light information generation portion.Type: ApplicationFiled: November 3, 2014Publication date: February 19, 2015Applicant: SYSMEX CORPORATIONInventors: Hideaki MATSUMOTO, Kinya UCHIHASHI, Yuji ITOSE, Aya KONISHI, Ayumu YOSHIDA
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Patent number: 8920726Abstract: This blood analyzer includes a sample preparation portion preparing a first measurement sample containing a blood sample and a hemolytic agent and a second measurement sample containing the blood sample, the same hemolytic agent as the hemolytic agent and a staining agent and a control portion classifying white blood cells in the first measurement sample into at least four groups of monocytes, neutrophils, eosinophils and others on the basis of fluorescent information and two types of scattered light information generated by a light information generation portion and classifying blood cells in the second measurement sample into at least malaria-infected red blood cells and others on the basis of fluorescent information and scattered light information generated by the light information generation portion.Type: GrantFiled: November 9, 2010Date of Patent: December 30, 2014Assignee: Sysmex CorporationInventors: Hideaki Matsumoto, Kinya Uchihashi, Yuji Itose, Aya Konishi, Ayumu Yoshida
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Publication number: 20140322750Abstract: This blood analyzer includes a sample preparation portion preparing a measurement sample free from a labeling substance from a blood sample and a hemolytic agent free from a labeling substance, a light information generation portion generating fluorescent information and at least two types of scattered light information from the measurement sample and a control portion performing a first classification of white blood cells in the measurement sample into at least four groups of monocytes, neutrophils, eosinophils and others on the basis of the fluorescent information and the two types of scattered light information.Type: ApplicationFiled: July 8, 2014Publication date: October 30, 2014Applicant: SYSMEX CORPORATIONInventors: Hideaki MATSUMOTO, Kinya UCHIHASHI, Yuji ITOSE, Aya KONISHI
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Patent number: 8868370Abstract: The present invention is a sample analyzing system, including a sample analyzer and a management apparatus connected to the sample analyzer via a communication network. The management apparatus includes: a first memory that stores a computer program for the sample analyzer and manual data which corresponds to a version of the computer program; a first communication device; and a first controller configured to transmit, via the first communication device to the sample analyzer, the computer program and the manual data corresponding to the version of the computer program stored in the first memory. The sample analyzer includes: a second communication device; a second memory that stores the computer program and the manual data received by the second communication device; and a second controller configured to execute the computer program stored in the second memory.Type: GrantFiled: September 22, 2011Date of Patent: October 21, 2014Assignee: Sysmex CorporationInventors: Naoki Shindo, Yusuke Suga, Aya Konishi, Daigo Fukuma, Keisuke Kuwano
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Patent number: 8808624Abstract: This blood analyzer includes a sample preparation portion preparing a measurement sample free from a labeling substance from a blood sample and a hemolytic agent free from a labeling substance, a light information generation portion generating fluorescent information and at least two types of scattered light information from the measurement sample and a control portion performing a first classification of white blood cells in the measurement sample into at least four groups of monocytes, neutrophils, eosinophils and others on the basis of the fluorescent information and the two types of scattered light information.Type: GrantFiled: November 9, 2010Date of Patent: August 19, 2014Assignee: Sysmex CorporationInventors: Hideaki Matsumoto, Kinya Uchihashi, Yuji Itose, Aya Konishi
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Publication number: 20120078514Abstract: The present invention is a sample analyzing system, comprising a sample analyzer and a management apparatus connected to the sample analyzer via a communication network. The management apparatus comprises: a first memory that stores a computer program for the sample analyzer and manual data which corresponds to a version of the computer program; a first communication device; and a first controller configured to transmit, via the first communication device to the sample analyzer, the computer program and the manual data corresponding to the version of the computer program stored in the first memory. The sample analyzer comprises: a second communication device; a second memory that stores the computer program and the manual data received by the second communication device; and a second controller configured to execute the computer program stored in the second memory.Type: ApplicationFiled: September 22, 2011Publication date: March 29, 2012Inventors: Naoki Shindo, Yusuke Suga, Aya Konishi, Daigo Fukuma, Keisuke Kuwano
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Patent number: 7923229Abstract: A method for classifying and counting leukocytes, which comprises steps of: staining cells in a sample obtained from a hematological sample by treatment with a hemolytic agent, with a fluorescent dye; introducing the sample containing the stained cells into a flow cytometer to measure first scattered light, second scattered light different from the first scattered light and fluorescence of the respective cells; obtaining scattered light peak intensities and scattered light widths of the respective cells based on the measured first scattered light, obtaining scattered light intensities of the respective cells based on the measured second scattered light, and obtaining fluorescence intensities of the respective cells based on the measured fluorescence light; classifying the cells into a first group and a second group based on the scattered light peak intensities and the scattered light widths, the first group including leukocytes and second group including platelet clumps; classifying the leukocytes included inType: GrantFiled: October 29, 2007Date of Patent: April 12, 2011Assignee: Sysmex CorporationInventors: Tomohiro Tsuji, Toshihiro Mizukami, Aya Konishi, Yusuke Mori, Yukie Nakazawa
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Publication number: 20110053212Abstract: This blood analyzer includes a sample preparation portion preparing a first measurement sample containing a blood sample and a hemolytic agent and a second measurement sample containing the blood sample, the same hemolytic agent as the hemolytic agent and a staining agent and a control portion classifying white blood cells in the first measurement sample into at least four groups of monocytes, neutrophils, eosinophils and others on the basis of fluorescent information and two types of scattered light information generated by a light information generation portion and classifying blood cells in the second measurement sample into at least malaria-infected red blood cells and others on the basis of fluorescent information and scattered light information generated by the light information generation portion.Type: ApplicationFiled: November 9, 2010Publication date: March 3, 2011Applicant: SYSMEX CORPORATIONInventors: Hideaki Matsumoto, Kinya Uchihashi, Yuji Itose, Aya Konishi, Ayumu Yoshida
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Publication number: 20110053210Abstract: This blood analyzer includes a sample preparation portion preparing a measurement sample free from a labeling substance from a blood sample and a hemolytic agent free from a labeling substance, a light information generation portion generating fluorescent information and at least two types of scattered light information from the measurement sample and a control portion performing a first classification of white blood cells in the measurement sample into at least four groups of monocytes, neutrophils, eosinophils and others on the basis of the fluorescent information and the two types of scattered light information.Type: ApplicationFiled: November 9, 2010Publication date: March 3, 2011Applicant: SYSMEX CORPORATIONInventors: Hideaki MATSUMOTO, Kinya Uchihashi, Yuji Itose, Aya Konishi
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Patent number: 7625730Abstract: There is provided a method for classifying and counting leukocytes with abnormal DNA amount, which comprises: (1) a step of staining cells in a sample obtained from a hematological sample by treatment with a hemolytic agent to lyse erythrocytes, with a fluorescent dye which can make a difference in the fluorescence intensity at least among mature leukocytes, leukocytes with abnormal DNA amount and immature leukocytes; (2) a step of introducing the sample containing the stained cells into a flow cytometer to measure scattered light and fluorescence of the respective cells; (3) a step of classifying leukocytes and coincidence cells/platelet clumps utilizing a difference in the intensity of a scattered light peak and a difference in the scattered light width; (4) a step of classifying and counting mature leukocytes, leukocytes with abnormal DNA amount and immature leukocytes, utilizing a difference in the scattered light intensity and a difference in the fluorescence intensity of leukocytes classified in theType: GrantFiled: June 23, 2003Date of Patent: December 1, 2009Assignee: Sysmex CorporationInventors: Tomohiro Tsuji, Toshihiro Mizukami, Aya Konishi, Yusuke Mori, Yukie Nakazawa
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Publication number: 20080176274Abstract: 1.Type: ApplicationFiled: October 29, 2007Publication date: July 24, 2008Applicant: SYSMEX CORPORATIONInventors: Tomohiro TSUJI, Toshihiro Mizukami, Aya Konishi, Yusuke Mori, Yukie Nakazawa
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Patent number: 7390677Abstract: An immunoassay comprises the steps of: (a) mixing a whole blood sample with sensitized insoluble carrier particles smaller than erythrocytes to cause an immune agglutination reaction; (b) introducing the resulting immune agglutination reaction mixture including agglutinated particles and unagglutinated particles to a flow cell, irradiating the particles passing through the flow cell with laser light, and detecting scattered lights generated thereby; (c) setting a threshold value for distinguishing unagglutinated particles from agglutinated particles and a threshold value for distinguishing the agglutinated particles from blood cells with regard to intensity of the scattered light; and (d) distinguishing and counting the unagglutinated particles, the agglutinated particles and the blood cells from the scattered lights detected in the step (b), in reference to the threshold values set in the step (c).Type: GrantFiled: June 11, 2001Date of Patent: June 24, 2008Assignee: Sysmex CorporationInventors: Kazuhiro Nakashima, Tsuneyoshi Torii, Hiroshi Tsuchiya, Shinya Uchida, Aya Konishi, Kunio Tanaka
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Patent number: 7354775Abstract: A reagent for partially lysing a cell membrane of a red blood cell infected with a malaria parasite, comprising: a first surfactant which has predetermined lysing ability for the red blood cell membrane; and a second surfactant which has weaker lysing ability than that of the first surfactant; wherein the reagent has pH of 5 to 7 and osmotic pressure of 200 to 300 mOsm/kg·H2O; and wherein the reagent partially lyses the malaria infected red blood cell membrane such that a malaria parasite is retained in the red blood cell and fluorescent dye passes through the cell membrane, is disclosed. A reagent for detecting malaria infected red blood cells, and a sample analyzing method for detecting malaria infected red blood cells, are also disclosed.Type: GrantFiled: March 28, 2006Date of Patent: April 8, 2008Assignee: Sysmex CorporationInventors: Ayumu Yoshida, Kinya Uchihashi, Yuji Itose, Aya Konishi, Hiromitsu Iizuka
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Publication number: 20060223137Abstract: A reagent for partially lysing a cell membrane of a red blood cell infected with a malaria parasite, comprising: a first surfactant which has predetermined lysing ability for the red blood cell membrane; and a second surfactant which has weaker lysing ability than that of the first surfactant; wherein the reagent has pH of 5 to 7 and osmotic pressure of 200 to 300 mOsm/kg·H2O; and wherein the reagent partially lyses the malaria infected red blood cell membrane such that a malaria parasite is retained in the red blood cell and fluorescent dye passes through the cell membrane, is disclosed. A reagent for detecting malaria infected red blood cells, and a sample analyzing method for detecting malaria infected red blood cells, are also disclosed.Type: ApplicationFiled: March 28, 2006Publication date: October 5, 2006Inventors: Ayumu Yoshida, Kinya Uchihashi, Yuji Itose, Aya Konishi, Hiromitsu Iizuka
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Publication number: 20050202400Abstract: There is provided a method for classifying and counting leukocytes with abnormal DNA amount, which comprises: (1) a step of staining cells in a sample obtained from a hematological sample by treatment with a hemolytic agent to lyse erythrocytes, with a fluorescent dye which can make a difference in the fluorescence intensity at least among mature leukocytes, leukocytes with abnormal DNA amount and immature leukocytes; (2) a step of introducing the sample containing the stained cells into a flow cytometer to measure scattered light and fluorescence of the respective cells; (3) a step of classifying leukocytes and coincidence cells/platelet clumps utilizing a difference in the intensity of a scattered light peak and a difference in the scattered light width; (4) a step of classifying and counting mature leukocytes, leukocytes with abnormal DNA amount and immature leukocytes, utilizing a difference in the scattered light intensity and a difference in the fluorescence intensity of leukocytes classified in the steType: ApplicationFiled: June 23, 2003Publication date: September 15, 2005Inventors: Tomohiro Tsuji, Toshihiro Mizukami, Aya Konishi, Yusuke Mori, Yukie Nakazawa
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Patent number: 6878558Abstract: A whole blood immunoassay includes the steps of mixing a whole blood sample with sensitized insoluble carrier particles to cause an immune agglutination; diluting the resulting agglutination mixture with an aqueous solution containing an erythrocyte lysing agent to lyse erythrocytes, thereby preparing an assay sample; and determining a degree of agglutination of the assay sample.Type: GrantFiled: July 27, 2001Date of Patent: April 12, 2005Assignee: Sysmex CorporationInventors: Shinya Uchida, Aya Konishi, Tsuneyoshi Torii, Kazuhiro Nakashima
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Publication number: 20030219850Abstract: An automatic method for analyzing nucleated bone marrow cells comprising partitioning one sample of bone marrow fluid with two samples, one sample being treated with a first lysing agent and a first staining solution and the other sample being treated with a second lysing agent and a second staining solution; andType: ApplicationFiled: May 13, 2003Publication date: November 27, 2003Applicant: Sysmex CorporationInventors: Tomohiro Tsuji, Yuji Itose, Aya Konishi
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Publication number: 20030082662Abstract: An immunoassay comprises the steps of: (a) mixing a whole blood sample with sensitized insoluble carrier particles smaller than erythrocytes to cause an immune agglutination reaction; (b) introducing the resulting immune agglutination reaction mixture including agglutinated particles and unagglutinated particles to a flow cell, irradiating the particles passing through the flow cell with laser light, and detecting scattered lights generated thereby; (c) setting a threshold value for distinguishing unagglutinated particles from agglutinated particles and a threshold value for distinguishing the agglutinated particles from blood cells with regard to intensity of the scattered light; and (d) distinguishing and counting the unagglutinated particles, the agglutinated particles and the blood cells from the scattered lights detected in the step (b), in reference to the threshold values set in the step (c).Type: ApplicationFiled: January 7, 2002Publication date: May 1, 2003Inventors: Kazuhiro Nakashima, Tsuneyoshi Torii, Hiroshi Tsuchiya, Shinya Uchida, Aya Konishi, Kunio Tanaka