Abstract: The present disclosure provides a channel device (100, 101, 102, 103, 200, 300, 500, 600, 700) including a flow channel (10) formed of a groove (31) provided in a substrate (30) and a porous membrane (50) having pores (56) communicating in a direction intersecting a thickness direction thereof, in which at least a portion of the porous membrane (50) in contact with the substrate (30) is liquid-tightly sealed along the flow channel (10), and a manufacturing method thereof.

Abstract: A production method of a mold having a recessed pattern includes: a plate precursor preparation step of preparing a plate precursor having a pedestal on which a protruding pattern is disposed; a resin plate preparation step of preparing a thermoplastic resin plate having a recessed step portion; and a resin plate precursor production step of producing a thermoplastic resin plate precursor. The plate precursor comprises a substrate having a larger area than the pedestal in a plan view on a side opposite to a surface of the pedestal on which the protruding pattern is disposed. An edge portion where a side surface of the pedestal and the substrate are in contact with each other has a through-hole penetrating the substrate along the side surface of the pedestal.

Abstract: A production method of a mold having a recessed pattern includes: a plate precursor preparation step of preparing a plate precursor having a pedestal on which a protruding pattern is disposed; a resin plate preparation step of preparing a thermoplastic resin plate having a recessed step portion; and a resin plate precursor production step of producing a thermoplastic resin plate precursor, the resin plate precursor production step including a positioning step of positioning the protruding pattern of the plate precursor and a center position of the recessed step portion, and a recessed pattern forming step of forming a recessed pattern having an inverted shape of the protruding pattern on the thermoplastic resin plate by pressing the protruding pattern of the heated plate precursor and the pedestal against the recessed step portion, thereafter cooling the plate precursor, and separating the plate precursor from the thermoplastic resin plate.

Abstract: A production method of a mold having a recessed pattern includes: a plate precursor preparation step of preparing a plate precursor having a pedestal on which a protruding pattern is disposed; a resin plate preparation step of preparing a thermoplastic resin plate having a recessed step portion; and a resin plate precursor production step of producing a thermoplastic resin plate precursor, the resin plate precursor production step including a positioning step of positioning the protruding pattern of the plate precursor and a center position of the recessed step portion, and a recessed pattern forming step of forming a recessed pattern having an inverted shape of the protruding pattern on the thermoplastic resin plate by pressing the protruding pattern of the heated plate precursor and the pedestal against the recessed step portion, thereafter cooling the plate precursor, and separating the plate precursor from the thermoplastic resin plate.

Abstract: Provided are a production method of a mold having a recessed pattern in a recessed step portion capable of preventing a liquid from flowing, and a manufacturing method of a pattern sheet.

Abstract: There is provided a method capable of manufacturing a mold at low cost, and a method of manufacturing a biocompatible pattern sheet by using the mold. The method of manufacturing a mold having a recessed pattern includes the steps of: forming a silicone resin film by applying a silicone resin solution to a surface of a model having a protrusion pattern; defoaming the silicone resin film by reducing the silicone resin film in pressure; forming the mold by heating and curing the silicone resin film while a base plate is in contact with a face of the silicone resin film, the face being opposite to the model; and releasing the mold from the model after releasing the base plate. The method of manufacturing a pattern sheet uses the mold.

Abstract: A method is provided which enables a drug to be concentrated at needle-like protruding portions and which further allows transdermal-absorption sheets to be manufactured at high production efficiency. The method repeats a step of feeding a drug-containing solution from a liquid feeding apparatus to a mold and filling needle-like recessed portions with the drug-containing solution through a nozzle aligned over the needle-like recessed portions in a state where the nozzle and a front surface of the mold are brought into contact with each other, and a step of moving the liquid feeding apparatus relative to the mold in a state where the nozzle and the front surface of the mold are brought into contact with each other. Thus, the two-dimensionally arranged needle-like recessed portions are filled with the drug-containing solution.

Abstract: The method of manufacturing a mold includes the steps of: forming a silicone resin film on a surface of a model having a protrusion pattern; pressing a side of a base plate with which a separation sheet is in close contacts on a gap adjustment mechanism and the silicone resin film; heating and curing the silicone resin film to form the mold; releasing the base plate; and releasing the separation sheet from the mold, after releasing the mold from the model, wherein the gap adjustment mechanism has a height at which a tip of the protrusion pattern sticks into the separation sheet when the base plate is pressed on the gap adjustment mechanism. The method of manufacturing a pattern sheet uses the mold.

Abstract: There is provided a method capable of manufacturing a mold at low cost, and a method of manufacturing a biocompatible pattern sheet by using the mold. The method of manufacturing a mold having a recessed pattern includes the steps of: forming a silicone resin film by applying a silicone resin solution to a surface of a model having a protrusion pattern; defoaming the silicone resin film by reducing the silicone resin film in pressure; forming the mold by heating and curing the silicone resin film while a base plate is in contact with a face of the silicone resin film, the face being opposite to the model; and releasing the mold from the model after releasing the base plate. The method of manufacturing a pattern sheet uses the mold.

Abstract: A method is provided which enables a drug to be concentrated at needle-like protruding portions and which further allows transdermal-absorption sheets to be manufactured at high production efficiency. The method repeats a step of feeding a drug-containing solution from a liquid feeding apparatus to a mold and filling needle-like recessed portions with the drug-containing solution through a nozzle aligned over the needle-like recessed portions in a state where the nozzle and a front surface of the mold are brought into contact with each other, and a step of moving the liquid feeding apparatus relative to the mold in a state where the nozzle and the front surface of the mold are brought into contact with each other. Thus, the two-dimensionally arranged needle-like recessed portions are filled with the drug-containing solution.

Abstract: A needle array transdermal absorption sheet to be attached onto a skin for supplying a drug into the skin, includes: a plurality of needle portions each having a tapered shape, each of the needle portions including a needle having a conical or pyramidal shape and a body part which has a columnar shape and whose end surface is connected to a base of the needle; a sheet portion having a flat-plate shape; and a plurality of frustum portions each having a frustum shape, the frustum portions which are arranged on a surface of the sheet portion in a manner that perimeters of larger bases of adjacent frustum portions are in contact with each other on the surface of the sheet portion, and smaller bases of which are respectively connected to the body parts of the needle portions.

Abstract: A method of fabricating a template (14) for a concave array mold (30) having a plurality of recesses of a high aspect ratio includes arranging a plurality of needles (10) in a mutually separated state and fixing the plurality of the arranged needles (10). This method allows a template for a concave array mold having a high aspect ratio structure to be easily and inexpensively fabricated. Further, the thus fabricated template can be used to easily and inexpensively fabricate a concave array mold. Furthermore, a needle array sheet can be fabricated by injecting and fixing a resin solution into the concave array mold (30) and separating the cured resin solution from the concave array mold (30).

Abstract: A needle array transdermal absorption sheet to be attached onto a skin for supplying a drug into the skin, includes: a plurality of needle portions each having a tapered shape, each of the needle portions including a needle having a conical or pyramidal shape and a body part which has a columnar shape and whose end surface is connected to a base of the needle; a sheet portion having a flat-plate shape; and a plurality of frustum portions each having a frustum shape, the frustum portions which are arranged on a surface of the sheet portion in a manner that perimeters of larger bases of adjacent frustum portions are in contact with each other on the surface of the sheet portion, and smaller bases of which are respectively connected to the body parts of the needle portions.

Abstract: A method of fabricating a template (14) for a concave array mold (30) having a plurality of recesses of a high aspect ratio includes arranging a plurality of needles (10) in a mutually separated state and fixing the plurality of the arranged needles (10). This method allows a template for a concave array mold having a high aspect ratio structure to be easily and inexpensively fabricated. Further, the thus fabricated template can be used to easily and inexpensively fabricate a concave array mold. Furthermore, a needle array sheet can be fabricated by injecting and fixing a resin solution into the concave array mold (30) and separating the cured resin solution from the concave array mold (30).

Abstract: An optical sheet allowing light which has entered the sheet through a sheet back surface to exit the sheet through a sheet front surface on which a prism portion is provided, includes an optical function part provided on a sheet end face extending between a circumferential edge of the sheet back surface and a circumferential edge of the sheet front surface for preventing leakage light from exiting the sheet through the sheet end face to return the light back into the sheet.