Patents by Inventor Aya Ohkubo

Aya Ohkubo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8673151
    Abstract: A method for surface modification of a material by means of introducing the phosphorylcholine group represented by the following formula (1-1) onto the surface of the material by treating a material having amino groups with a chemical compound containing an aldehyde derivative obtained by the oxidative ring-opening reaction of glycerophosphorylcholine. The method of the present invention provides various materials such as medical materials having superior biocompatibility and hydrophilicity.
    Type: Grant
    Filed: June 24, 2009
    Date of Patent: March 18, 2014
    Assignee: Shiseido Company, Ltd.
    Inventors: Kazuyuki Miyazawa, Taketoshi Kanda, Yousuke Toujo, Aya Ohkubo, Osamu Shirota, Kenichi Sakuma, Masayoshi Wada
  • Publication number: 20100285252
    Abstract: A method for surface modification of a material by means of introducing the phosphorylcholine group represented by the following formula (1-1) onto the surface of the material by treating a material having amino groups with a chemical compound containing an aldehyde derivative obtained by the oxidative ring-opening reaction of glycerophosphorylcholine. The method of the present invention provides various materials such as medical materials having superior biocompatibility and hydrophilicity.
    Type: Application
    Filed: June 24, 2009
    Publication date: November 11, 2010
    Applicant: Shiseido Company, Ltd.
    Inventors: Kazuyuki Miyazawa, Taketoshi Kanda, Yousuke Toujo, Aya Ohkubo, Osamu Shirota, Kenichi Sakuma, Masayoshi Wada
  • Patent number: 7560023
    Abstract: A method for surface modification of a material by means of introducing the phosphorylcholine group represented by the following formula (1-1) onto the surface of the material by treating a material having amino groups with a chemical compound containing an aldehyde derivative obtained by the oxidative ring-opening reaction of glycerophosphorylcholine. The method of the present invention provides various materials such as medical materials having superior biocompatibility and hydrophilicity.
    Type: Grant
    Filed: November 20, 2003
    Date of Patent: July 14, 2009
    Assignee: Shiseido Company, Ltd.
    Inventors: Kazuyuki Miyazawa, Taketoshi Kanda, Yousuke Toujo, Aya Ohkubo, Osamu Shirota, Kenichi Sakuma, Masayoshi Wada
  • Patent number: 7500386
    Abstract: A sample injection apparatus and a liquid chromatography apparatus including the sample injection apparatus are provided. The sample injection apparatus includes a sampling vessel into which a sample is supplied, a sampling needle for aspirating and ejecting the sample, a cleaning part into which a cleaning liquid for cleaning at least the sampling needle is supplied, a sample injection part for injecting the sample ejected from the sampling needle into a moving liquid, and a needle transfer part for transferring the sampling needle among the sampling vessel, the cleaning part and the sample injection part, wherein the cleaning part includes an ultrasonic vibrator for generating an ultrasonic wave in the cleaning liquid.
    Type: Grant
    Filed: February 4, 2008
    Date of Patent: March 10, 2009
    Assignee: Shiseido Company, Ltd.
    Inventors: Yuki Togashi, Osamu Shirota, Aya Ohkubo
  • Publication number: 20080141762
    Abstract: A sample injection apparatus and a liquid chromatography apparatus including the sample injection apparatus are provided. The sample injection apparatus includes a sampling vessel into which a sample is supplied, a sampling needle for aspirating and ejecting the sample, a cleaning part into which a cleaning liquid for cleaning at least the sampling needle is supplied, a sample injection part for injecting the sample ejected from the sampling needle into a moving liquid, and a needle transfer part for transferring the sampling needle among the sampling vessel, the cleaning part and the sample injection part, wherein the cleaning part includes an ultrasonic vibrator for generating an ultrasonic wave in the cleaning liquid.
    Type: Application
    Filed: February 4, 2008
    Publication date: June 19, 2008
    Applicant: Shiseido Company, Ltd.
    Inventors: Yuki Togashi, Osamu Shirota, Aya Ohkubo
  • Patent number: 7337653
    Abstract: A sample injection apparatus and sample injection method capable of sufficiently reducing carry-over, having simple cleaning means for a short cleaning time period, a small influence of vibration of the cleaning means, and a small error in the amount of injected sample and preventing the durability of a sampling needle from being lowered, and a liquid chromatography apparatus having the sample injection apparatus are provided.
    Type: Grant
    Filed: May 14, 2004
    Date of Patent: March 4, 2008
    Assignee: Shiseido Company, Ltd.
    Inventors: Yuki Togashi, Osamu Shirota, Aya Ohkubo
  • Publication number: 20060213257
    Abstract: A sample injection apparatus and sample injection method capable of sufficiently reducing carry-over, having simple cleaning means for a short cleaning time period, a small influence of vibration of the cleaning means, and a small error in the amount of injected sample and preventing the durability of a sampling needle from being lowered, and a liquid chromatography apparatus having the sample injection apparatus are provided.
    Type: Application
    Filed: May 14, 2004
    Publication date: September 28, 2006
    Applicant: Shiseido Company, Ltd.
    Inventors: Yuki Togashi, Osamu Shirota, Aya Ohkubo
  • Publication number: 20060060533
    Abstract: A method for surface modification of a material by means of introducing the phosphorylcholine group represented by the following formula (1-1) onto the surface of the material by treating a material having amino groups with a chemical compound containing an aldehyde derivative obtained by the oxidative ring-opening reaction of glycerophosphorylcholine. The method of the present invention provides various materials such as medical materials having superior biocompatibility and hydrophilicity.
    Type: Application
    Filed: November 20, 2003
    Publication date: March 23, 2006
    Inventors: Kazuyuki Miyazawa, Taketoshi Kanda, Yousuke Toujo, Aya Ohkubo, Osamu Shirota, Kenichi Sukuma, Masayoshi Wada
  • Publication number: 20040101968
    Abstract: A chelate reagent containing an analytical chelating agent for measuring aluminum to be used in a method of measuring the amount of aluminum contained in a sample which comprises forming a complex of aluminum in the sample with the analytical chelating agent under such conditions that the equivalent concentration of the analytical chelating agent in the liquid reaction mixture is 6 times or more as high as the conventional level and then chromatographically detecting the complex. By using this reagent, the content of aluminum in a sample can be conveniently and highly accurately determined chromatographically without affected by any interfering substances.
    Type: Application
    Filed: March 12, 2003
    Publication date: May 27, 2004
    Inventors: Aya Ohkubo, Osamu Shirota, Makoto Sato, Hajime Yoshimura
  • Patent number: 6360589
    Abstract: A liquid chromatograph and a column packing material effectively condensing cationic specimen and exhibiting a high resolution. The liquid chromatograph includes a pre-focusing column (30, 40) having a volume of less than 2.0 milliliters and packed with a column packing material, in which a porous support is coated by a silicone polymer having a Si—R—X (R is a spacer part, X is a sulfonic group) bond and a Si—R′ (R′ is a hydrophilic group) bond, wherein the specimen to be analyzed is supplied to the pre-focusing column in the state dispersed in a solvent for condensation. The condensed specimen is then separated in a separation column (16, 43) used for separating the specimen dispersed in the solvent, and the separated specimen is analyzed by a detector (17, 41).
    Type: Grant
    Filed: November 25, 1998
    Date of Patent: March 26, 2002
    Assignee: Shiseido Company, Ltd.
    Inventors: Taketoshi Kanda, Aya Ohkubo, Yutaka Ohtsu, Michihiro Yamaguchi