Patents by Inventor Ayaka Mochizuki

Ayaka Mochizuki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Block copolymer conjugate of physiologically active substance
    Patent number: 10357573
    Abstract: A physiologically active substance-conjugated block copolymer having enhanced efficacy and/or safety is provided by enhancing the property of penetrating into a target diseased tissue and/or enhancing excretability, compared to known physiologically active substance-conjugated block copolymer, and suppressing sensitization of the physiologically active substance to normal tissues other than a target diseased tissue. Disclosed is a block copolymer including a polyethylene glycol segment connected with a polyamino acid derivative segment conjugated with a physiologically active substance, in which the molecular weight of the block copolymer is from 2 kilodaltons to 15 kilodaltons, and the light scattering intensity of a 1 mg/mL aqueous solution of the physiologically active substance-conjugated block copolymer as measured with a laser light scattering photometer is at least twice or more the light scattering intensity of toluene.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: July 23, 2019
    Assignee: Nippon Kayaku Kabushiki Kaisha
    Inventors: Takeshi Onda, Akira Masuda, Ken Yamakawa, Chisato Tomiyama, Yasushi Yoneta, Yuichi Akatsu, Keiichirou Yamamoto, Ayaka Mochizuki
  • Block Copolymer Conjugate Of Physiologically Active Substance
    Publication number: 20180050112
    Abstract: A physiologically active substance-conjugated block copolymer having enhanced efficacy and/or safety is provided by enhancing the property of penetrating into a target diseased tissue and/or enhancing excretability, compared to known physiologically active substance-conjugated block copolymer, and suppressing sensitization of the physiologically active substance to normal tissues other than a target diseased tissue. Disclosed is a block copolymer including a polyethylene glycol segment connected with a polyamino acid derivative segment conjugated with a physiologically active substance, in which the molecular weight of the block copolymer is from 2 kilodaltons to 15 kilodaltons, and the light scattering intensity of a 1 mg/mL aqueous solution of the physiologically active substance-conjugated block copolymer as measured with a laser light scattering photometer is at least twice or more the light scattering intensity of toluene.
    Type: Application
    Filed: February 19, 2016
    Publication date: February 22, 2018
    Inventors: Takeshi Onda, Akira Masuda, Ken Yamakawa, Chisato Tomiyama, Yasushi Yoneta, Yuichi Akatsu, Keiichirou Yamamoto, Ayaka Mochizuki