Patents by Inventor Ayako Yamashita

Ayako Yamashita has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes for the 3,3-dialkylation of 4-chromanones
    Patent number: 7671220
    Abstract: The present invention relates to methods for the preparation of 3,3-dialky 4-chromanones, and particularly to the preparation of 6-fluoro-3,3-dimethyl-2,3-dihydro-4H-chromen-4-one and 3,3-dimethyl-2,3-dihydro-4H-chromen-4-one. In some embodiments, the processes include reaction of a 4-chromanone compound with an alkyl halide in the presence of a metal alkoxide at low temperature.
    Type: Grant
    Filed: February 15, 2006
    Date of Patent: March 2, 2010
    Assignee: Wyeth
    Inventors: Ayako Yamashita, Emily B. Norton, Jaechul Shim, Cilien S. Hanna
  • Compounds for treating tumors
    Patent number: 7626023
    Abstract: The invention provides compounds of formula (I): wherein E, A, B?, R6, R7, R8, and R9 are defined in the specification which compounds exhibit anticancer activity and are useful for treating cancer.
    Type: Grant
    Filed: April 17, 2008
    Date of Patent: December 1, 2009
    Assignee: Wyeth
    Inventors: Arie Zask, Joshua Kaplan, Ayako Yamashita, Chuan S. Niu, Gary Harold Birnberg, Emily Norton, Kinwang Cheung, Ronald Suayan, Vincent Sandanayaka, Philip Ross Hamann, Semiramis Ayral-Kaloustian
  • COMPOUNDS FOR TREATING TUMORS
    Publication number: 20080221181
    Abstract: The invention provides compounds of formula (I): wherein E, A, B?, R6, R7, R8, and R9 are defined in the specification which compounds exhibit anticancer activity and are useful for treating cancer.
    Type: Application
    Filed: April 17, 2008
    Publication date: September 11, 2008
    Applicant: Wyeth Holdings Corporation
    Inventors: Arie Zask, Joshua Kaplan, Ayako Yamashita, Chuan S. Niu, Gary Harold Birnberg, Emily Norton, Kinwang Cheung, Ronald Suayan, Vincent Sandanayaka, Philip Ross Hamann, Semiramis Ayral-Kaloustian
  • Compounds for treating tumors
    Patent number: 7390910
    Abstract: The invention provides compounds of formula (I): wherein E, A, B?, R6, R7, R8, and R9 are defined in the specification which compounds exhibit anticancer activity and are useful for treating cancer.
    Type: Grant
    Filed: August 4, 2004
    Date of Patent: June 24, 2008
    Assignee: Wyeth
    Inventors: Arie Zask, Joshua Kaplan, Ayako Yamashita, Chuan S. Niu, Gary Harold Birnberg, Emily Norton, Kinwang Cheung, Ronald Suayan, Vincent Sandanayaka, Philip Ross Hamann, Semiramis Ayral-Kaloustian
  • Processes for the 3,3-dialkylation of 4-chromanones
    Publication number: 20060183924
    Abstract: The present invention relates to methods for the preparation of 3,3-dialky 4-chromanones, and particularly to the preparation of 6-fluoro-3,3-dimethyl-2,3-dihydro-4H-chromen-4-one and 3,3-dimethyl-2,3-dihydro-4H-chromen-4-one. In some embodiments, the processes include reaction of a 4-chromanone compound with an alkyl halide in the presence of a metal alkoxide at low temperature.
    Type: Application
    Filed: February 15, 2006
    Publication date: August 17, 2006
    Applicant: Wyeth
    Inventors: Ayako Yamashita, Emily Norton, Jaechul Shim, Cilien Hanna
  • Antibiotic AA 896 analogs
    Patent number: 6858591
    Abstract: The invention provides compounds of the Formula 1 wherein the definitions of m, n, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and R13 are in the specification. These compounds are useful as antibacterial agents.
    Type: Grant
    Filed: April 25, 2002
    Date of Patent: February 22, 2005
    Assignee: Wyeth Holdings Corporation
    Inventors: Ayako Yamashita, Emily Boucher Norton
  • Compounds for treating tumors
    Publication number: 20050037977
    Abstract: The invention provides compounds of formula (I): wherein E, A, B?, R6, R7, R8, and R9 are defined in the specification which compounds exhibit anticancer activity and are useful for treating cancer.
    Type: Application
    Filed: August 4, 2004
    Publication date: February 17, 2005
    Applicant: Wyeth Holdings Corporation
    Inventors: Arie Zask, Joshua Kaplan, Ayako Yamashita, Chuan Niu, Gary Birnberg, Emily Norton, Kinwang Cheung, Ronald Suayan, Vincent Sandanayaka, Philip Hamann, Semiramis Ayral-Kaloustian
  • 3-Cyanoquinolines,3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors
    Publication number: 20040176602
    Abstract: This invention provides compounds of Formula (I), having the structure 1
    Type: Application
    Filed: January 9, 2004
    Publication date: September 9, 2004
    Applicant: Wyeth
    Inventors: Diane Harris Boschelli, Yanong Wang, Frank Charles Boschelli, Dan Maarten Berger, Nan Zhang, Dennis William Powell, Fei Ye, Ayako Yamashita, Frenel Fils DeMorin, Biqi Wu, Hwei-Ru Tsou, Elsebe Geraldine Overbeek-Klumpers, Allan Wissner
  • 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors
    Patent number: 6689772
    Abstract: This invention provides compounds of Formula (I), having the structure where T, Z, X, A, R1, R2a, R2b, R2c, R3, R4, and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of osteoporosis and polycystic kidney disease.
    Type: Grant
    Filed: December 12, 2002
    Date of Patent: February 10, 2004
    Assignee: Wyeth
    Inventors: Diane Harris Boschelli, Yanong Wang, Frank Charles Boschelli, Dan Maarten Berger, Nan Zhang, Dennis William Powell, Fei Ye, Ayako Yamashita, Frenel Fils DeMorin, Biqi Wu, Hwei-Ru Tsou, Elsebe Geraldine Overbeek-Klumpers, Allan Wissner
  • Antibiotic AA 896 analogs
    Publication number: 20030087874
    Abstract: The invention provides compounds of the Formula 1 1
    Type: Application
    Filed: April 25, 2002
    Publication date: May 8, 2003
    Applicant: American Cyanamid Company
    Inventors: Ayako Yamashita, Emily Boucher Norton
  • Substituted 3-cyano-[1.7], [1.5], and [1.8] naphthyridine inhibitors of tyrosine kinases
    Patent number: 6548496
    Abstract: This invention provides compounds of formula I having the structure Wherein substitutions at A″, Z, n, and X are set forth in the specification.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: April 15, 2003
    Assignee: American Cyanamid Company
    Inventors: Allan Wissner, Philip R. Hamann, Ayako Yamashita
  • 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors
    Patent number: 6521618
    Abstract: This invention provides compounds of Formula (I), having the structure where T, Z, X, A, R1, R2a, R2b, R2c, R3, R4, and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of osteoporosis and polycystic kidney disease.
    Type: Grant
    Filed: March 28, 2001
    Date of Patent: February 18, 2003
    Assignee: Wyeth
    Inventors: Diane Harris Boschelli, Yanong Wang, Frank Charles Boschelli, Dan Maarten Berger, Nan Zhang, Dennis William Powell, Fei Ye, Ayako Yamashita, Frenel Fils DeMorin, Biqi Wu, Hwei-Ru Tsou, Elsebe Geraldine Overbeek-Klumpers, Allan Wissner
  • Substituted 3-cyano-[1.7], [1.5], and [1.8] naphthyridine inhibitors of tyrosine kinases
    Publication number: 20020165229
    Abstract: This invention provides compounds of formula I having the structure 1
    Type: Application
    Filed: December 21, 2001
    Publication date: November 7, 2002
    Applicant: American Cyanamid Company
    Inventors: Allan Wissner, Philip R. Hamann, Ayako Yamashita
  • Substituted 3-cyano-[1.7],[1.5], and [1.8] naphthyridine inhibitors of tyrosine kinases
    Patent number: 6355636
    Abstract: This invention provides compounds of formula I having the structure useful as inhibitors of protein tyrosine kinase.
    Type: Grant
    Filed: April 18, 2000
    Date of Patent: March 12, 2002
    Assignee: American Cyanamid Company
    Inventors: Allan Wissner, Philip R. Hamann, Ayako Yamashita
  • 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors
    Publication number: 20020026052
    Abstract: This invention provides compounds of Formula (I), having the structure 1
    Type: Application
    Filed: March 28, 2001
    Publication date: February 28, 2002
    Applicant: American Home Products Corporation
    Inventors: Diane Harris Boschelli, Yanong Wang, Frank Charles Boschelli, Dan Maarten Berger, Nan Zhang, Dennis William Powell, Fei Ye, Ayako Yamashita, Frenel Fils Demorin, Biqi Wu, Hwei-Ru Tsou, Elsebe Geraldine Overbeek-Klumpers, Allan Wissner
  • Intermediates for antiatherosclerotic furochromones
    Patent number: 4758676
    Abstract: The present invention provides novel compositions of matter and processes for their preparation. More particularly, the present invention consists of novel chemical intermediates and associated processes for the preparation of khellin and analogues thereof, which have demonstrated antiatherosclerotic activity.
    Type: Grant
    Filed: August 29, 1986
    Date of Patent: July 19, 1988
    Assignee: The Upjohn Company
    Inventor: Ayako Yamashita
  • Substituted naphthalenes, indoles, benzofurans, and benzothiophenes as lipoxygenase inhibitors
    Patent number: 4737519
    Abstract: The present invention provides certain novel substituted naphthalenes, indoles, benzofurans, and benzothiophenes of Formula I which are useful as inhibitors of leukotriene biosynthesis and as inhibitors of lipoxygenase. They are thus employed wherever it is medically necessary or desirable to inhibit these systems.
    Type: Grant
    Filed: June 25, 1986
    Date of Patent: April 12, 1988
    Assignee: The Upjohn Company
    Inventors: Ayako Yamashita, Herbert G. Johnson
  • Synthesis of precursors of anti-atherosclerotic furochromones
    Patent number: 4623737
    Abstract: The present invention provides novel compositions of matter and processes for their preparation. More particularly, the present invention consists of novel chemical intermediates and associated processes for the preparation of khellin and analogues thereof, which have demonstrated antiatherosclerotic activity.
    Type: Grant
    Filed: December 7, 1984
    Date of Patent: November 18, 1986
    Assignee: The Upjohn Company
    Inventor: Ayako Yamashita