Patents by Inventor Ayala Lewkowicz
Ayala Lewkowicz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230144459Abstract: Agents comprising at least two moieties separated by a linker, wherein a first moiety binds mCD28 on a surface of a cell and inhibits proteolytic cleavage of the mCD28 and wherein a second moiety increases stability of the first moiety are provided. Methods of treating cancer and improving immunotherapy comprising administering the agents are also provided.Type: ApplicationFiled: March 11, 2021Publication date: May 11, 2023Inventors: Motti HAKIM, Anna FRIDMAN-DROR, Ilana MANDEL, Tehila BEN-MOSHE, Yair SAPIR, Avidor SHULMAN, Lilach Chen ZELTSBURG, Ayala LEWKOWICZ
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Publication number: 20160095907Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.Type: ApplicationFiled: November 11, 2015Publication date: April 7, 2016Applicant: PROTALIX LTD.Inventors: Yoseph SHAALTIEL, Gideon BAUM, Daniel BARTFELD, Sharon HASHMUELI, Ayala LEWKOWICZ
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Patent number: 9220737Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.Type: GrantFiled: June 2, 2014Date of Patent: December 29, 2015Assignee: Protalix Ltd.Inventors: Yoseph Shaaltiel, Gideon Baum, Daniel Bartfeld, Sharon Hashmueli, Ayala Lewkowicz
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Publication number: 20140271577Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.Type: ApplicationFiled: June 2, 2014Publication date: September 18, 2014Applicant: Protalix Ltd.Inventors: Yoseph SHAALTIEL, Gideon Baum, Daniel Bartfeld, Sharon Hashmueli, Ayala Lewkowicz
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Patent number: 8790641Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.Type: GrantFiled: April 23, 2009Date of Patent: July 29, 2014Assignee: Protalix Ltd.Inventors: Yoseph Shaaltiel, Gideon Baum, Daniel Bartfeld, Sharon Hashmueli, Ayala Lewkowicz
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Patent number: 8741620Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.Type: GrantFiled: July 23, 2012Date of Patent: June 3, 2014Assignee: Protalix Ltd.Inventors: Yoseph Shaaltiel, Gideon Baum, Daniel Bartfeld, Sharon Hashmueli, Ayala Lewkowicz
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Patent number: 8449876Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.Type: GrantFiled: April 6, 2011Date of Patent: May 28, 2013Assignee: Protalix Ltd.Inventors: Yoseph Shaaltiel, Gideon Baum, Daniel Bartfeld, Sharon Hashmueli, Ayala Lewkowicz
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Publication number: 20120282231Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.Type: ApplicationFiled: July 23, 2012Publication date: November 8, 2012Applicant: Protalix Ltd.Inventors: Yoseph Shaaltiel, Gideon Baum, Daniel Bartfeld, Sharon Hashmueli, Ayala Lewkowicz
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Patent number: 8227230Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.Type: GrantFiled: April 6, 2011Date of Patent: July 24, 2012Assignee: Protalix Ltd.Inventors: Yoseph Shaaltiel, Gideon Baum, Daniel Bartfeld, Sharon Hashmueli, Ayala Lewkowicz
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Publication number: 20110250181Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.Type: ApplicationFiled: April 6, 2011Publication date: October 13, 2011Applicant: Protalix Ltd.Inventors: Yoseph SHAALTIEL, Gideon Baum, Daniel Bartfeld, Sharon Hashmueli, Ayala Lewkowicz
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Publication number: 20110182868Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.Type: ApplicationFiled: April 6, 2011Publication date: July 28, 2011Applicant: Protalix Ltd.Inventors: Yoseph SHAALTIEL, Gideon Baum, Daniel Bartfeld, Sharon Hashmueli, Ayala Lewkowicz
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Patent number: 7951557Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.Type: GrantFiled: April 30, 2007Date of Patent: May 31, 2011Assignee: Protalix Ltd.Inventors: Yoseph Shaaltiel, Gideon Baum, Daniel Bartfeld, Sharon Hashmueli, Ayala Lewkowicz
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Publication number: 20100196345Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.Type: ApplicationFiled: April 30, 2008Publication date: August 5, 2010Applicant: ProtalixInventors: Yoseph Shaaltiel, Gideon Baum, Daniel Bartfeld, Sharon Hashmueli, Ayala Lewkowicz
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Publication number: 20090208477Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.Type: ApplicationFiled: April 23, 2009Publication date: August 20, 2009Applicant: Protalix Ltd.Inventors: Yoseph Shaaltiel, Gideon Baum, Daniel Bartfeld, Sharon Hashmueli, Ayala Lewkowicz
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Publication number: 20080038232Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.Type: ApplicationFiled: April 30, 2007Publication date: February 14, 2008Applicant: Protalix Ltd.Inventors: Yoseph Shaaltiel, Gideon Baum, Daniel Bartfeld, Sharon Hashmueli, Ayala Lewkowicz
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Publication number: 20060204487Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.Type: ApplicationFiled: February 24, 2004Publication date: September 14, 2006Applicant: PROTALIX LTD.Inventors: Yoseph Shaaltiel, Gideon Baum, Sharon Hashmueli, Ayala Lewkowicz, Daniel Bartfeld