Abstract: The synthetic peptide disclosed here includes (1) an amino acid sequence represented by any of SEQ ID NOS:1 to 10, or a modified amino sequence formed by deletion, substitution or addition of 1, 2 or 3 amino acid residues in any of these amino acid sequences, together with (2) an amino acid sequence (CPP sequence) that functions as a cell penetrating peptide (CPP), and consists of a total of not more than 100 amino acid residues.

Abstract: The synthetic peptide disclosed here includes (1) an amino acid sequence represented by any of SEQ ID NOS:1 to 10, or a modified amino sequence formed by deletion, substitution or addition of 1, 2 or 3 amino acid residues in any of these amino acid sequences, together with (2) an amino acid sequence (CPP sequence) that functions as a cell penetrating peptide (CPP), and consists of a total of not more than 100 amino acid residues.

Abstract: An antiviral peptide provided according to the present invention includes (1) an amino acid sequence (TM sequence) constituting a transmembrane region of G protein of vesicular stomatitis virus (VSV) or a modified amino acid sequence formed by conservative substitutions of 1, 2, or 3 amino acid residues in the TM sequence; and (2) an amino acid sequence (CPP sequence) functioning as a cell penetrating peptide (CPP), wherein a total number of amino acid residues is 100 or less.

Abstract: The objective of the present invention is to provide a novel compound inhibiting the entry of a filovirus into a cell, a medical composition, an anti-filovirus agent, or a filovirus entry inhibitor containing the compound, as well as a method for inhibiting a filovirus cell entry process in vitro, a method for treating a filovirus infectious disease, and the like. The objective has been achieved by providing: the compound represented by formula (I) or a hydrate thereof; or a pharmaceutically acceptable salt of the compound or a hydrate thereof.

Abstract: An antiviral peptide provided by the present invention includes: (1) the signal sequence of a glycoprotein encoded for by the G gene of the vesicular stomatitis virus (VSV), or the signal sequence of hemagglutinin encoded for by the HA gene of the influenza A or influenza B virus, or a modified amino acid sequence formed by conservative substitution of 1, 2 or 3 amino acid residues in any of these signal sequences; and (2) an amino acid sequence that functions as a cell penetrating peptide (CPP).

Abstract: There has been a need for a neutralizing monoclonal antibody which is useful for antibody therapy effective against ebolavirus. The present invention provides a monoclonal antibody or an antigen-binding fragment thereof, which recognizes an internal fusion loop of ebolavirus GP and is capable of neutralizing the biological activity of ebolavirus.

Abstract: An antiviral peptide provided according to the present invention includes (1) an amino acid sequence (TM sequence) constituting a transmembrane region of G protein of vesicular stomatitis virus (VSV) or a modified amino acid sequence formed by conservative substitutions of 1, 2, or 3 amino acid residues in the TM sequence; and (2) an amino acid sequence (CPP sequence) functioning as a cell penetrating peptide (CPP), wherein a total number of amino acid residues is 100 or less.

Abstract: This application relates to an useful drug for prevention or treatment of avian influenza virus infection, and specifically provides a multiple antigen peptide comprising a dendritic core and 4-8 antigen peptides, wherein each of the antigen peptides is bound to a terminus of the dendritic core directly or through a spacer, and is a peptide consisting of 7-12 consecutive amino acids in the amino acid sequence of SEQ ID NO: 4, the multiple antigen peptide inducing the production of IgG antibodies in mammalian animals or birds, and further provides an immunity inducer comprising the multiple antigen peptide.

Abstract: This application provides: a multiple antigen peptide comprising a dendritic core and 4-8 antigen peptides, wherein each of the antigen peptides is bound to a terminus of the dendritic core directly or through a spacer and is a peptide consisting of 7-15 consecutive amino acids in the amino acid sequence of SEQ ID NO: 1, or a peptide which is the same as the peptide except that 1-3 amino acids are substituted; and an immune inducer comprising the multiple antigen peptide(s), wherein the multiple antigen peptide and the immune inducer are both useful for prevention or treatment of Ebola virus infection.

Abstract: An antiviral peptide provided by the present invention includes: (1) the signal sequence of a glycoprotein encoded for by the G gene of the vesicular stomatitis virus (VSV), or the signal sequence of hemagglutinin encoded for by the HA gene of the influenza A or influenza B virus, or a modified amino acid sequence formed by conservative substitution of 1, 2 or 3 amino acid residues in any of these signal sequences; and (2) an amino acid sequence that functions as a cell penetrating peptide (CPP).

Abstract: There has been a need for a neutralizing monoclonal antibody which is useful for antibody therapy effective against ebolavirus. The present invention provides a monoclonal antibody or an antigen-binding fragment thereof, which recognizes an internal fusion loop of ebolavirus GP and is capable of neutralizing the biological activity of ebolavirus.

Abstract: A transport apparatus transports a container that includes a flow hole forming portion in which a flow hole through which gas can flow between the outside and the inside of the container is formed. A connecting portion that has a flow path through which gas can flow and a filling gas supply source that allows a filling gas to flow through the flow path are provided in the transport apparatus. The connecting portion is configured to be switchable between a non-connected state in which the connecting portion is retracted to the outside of a moving region of the container that moves along a transport path and a connected state in which the connecting portion enters the inside of the moving region and is connected to the flow hole forming portion of the container.

Abstract: A sub-path is connected to a first main path and a second main path along which an article transport vehicle travels in a direction opposite to that of the first main path. The sub-path includes an intersection portion, a first upstream path connected to the first main path and the intersection portion, a second upstream path connected to the second main path and the intersection portion, a first downstream path connected to the intersection portion and the second main path, and a second downstream path connected to the intersection portion and the first main path. In the intersection portion, a first connection path that connects the first upstream path and the first downstream path, and a second connection path that connects the second upstream path and the second downstream path are provided so as to be located at the same height and to intersect each other.

Abstract: A transport apparatus transports a container that includes a flow hole forming portion in which a flow hole through which gas can flow between the outside and the inside of the container is formed. A connecting portion that has a flow path through which gas can flow and a filling gas supply source that allows a filling gas to flow through the flow path are provided in the transport apparatus. The connecting portion is configured to be switchable between a non-connected state in which the connecting portion is retracted to the outside of a moving region of the container that moves along a transport path and a connected state in which the connecting portion enters the inside of the moving region and is connected to the flow hole forming portion of the container.

Abstract: Antibodies useful to prevent, inhibit or treat Ebola virus infection, vectors encoding and host cells expressing one or more heavy chains or light chains that bind Ebola virus, are provided.

Abstract: An article transport facility includes a connecting actuator device for moving an eject portion of an inactive gas supplying device relative to a support portion of a ceiling transport vehicle in order to change the positional relationship between the support portion and the eject portion between a connecting positional relationship and a separating positional relationship. The inactive gas supplying device is configured to eject the inactive gas from the eject portion with the connection between the eject portion and the container maintained after the positional relationship between the support portion and the eject portion is changed to the connecting positional relationship.

Abstract: A sub-path is connected to a first main path and a second main path along which an article transport vehicle travels in a direction opposite to that of the first main path. The sub-path includes an intersection portion, a first upstream path connected to the first main path and the intersection portion, a second upstream path connected to the second main path and the intersection portion, a first downstream path connected to the intersection portion and the second main path, and a second downstream path connected to the intersection portion and the first main path. In the intersection portion, a first connection path that connects the first upstream path and the first downstream path, and a second connection path that connects the second upstream path and the second downstream path are provided so as to be located at the same height and to intersect each other.

Abstract: An article transport facility includes a connecting actuator device for moving an eject portion of an inactive gas supplying device relative to a support portion of a ceiling transport vehicle in order to change the positional relationship between the support portion and the eject portion between a connecting positional relationship and a separating positional relationship. The inactive gas supplying device is configured to eject the inactive gas from the eject portion with the connection between the eject portion and the container maintained after the positional relationship between the support portion and the eject portion is changed to the connecting positional relationship.