Patents by Inventor Aye Mar

Aye Mar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 23-Substituted Derivatives of Lupane-type Pentacyclic Triterpenoids
    Publication number: 20100144688
    Abstract: The present invention comprises small molecule inhibitors of cell proliferative conditions, in particular cancer and conditions associated with cancer. For example, associated malignancies include ovarian cancer, cervical cancer, breast cancer, colorectal cancer, and glioblastomas, among others. Accordingly, the compounds of the present invention are useful for treating, preventing, and/or inhibiting these diseases. Thus, the present invention also comprises pharmaceutical formulations comprising the compounds and methods of using the compounds and formulations to inhibit cancer and treat, prevent, or inhibit the foregoing diseases.
    Type: Application
    Filed: December 9, 2009
    Publication date: June 10, 2010
    Applicant: ADVANCED LIFE SCIENCES, INC.
    Inventors: Ali Koohang, Aye Aye Mar, Erika Szotek, Ze-Qi Xu, David A. Eiznhamer, Michael T. Flavin
  • Lupane-Type Triterpenoids Modified at 30-Position and Analogues Thereof
    Publication number: 20090062243
    Abstract: The present invention comprises lupine-type triterpenoids that inhibit cell proliferations, in particular cancer and conditions associated with cancer. For example, associated malignancies include ovarian cancer, cervical cancer, breast cancer, colorectal cancer, and glioblastomas, among others. Accordingly, the compounds of the present invention are useful for treating, preventing, and/or inhibiting these diseases. Thus, the present invention also comprising pharmaceutical formulations comprising the compounds and methods of using the compounds and formulations to inhibit cancer and treat, prevent, or inhibit the foregoing diseases.
    Type: Application
    Filed: July 10, 2008
    Publication date: March 5, 2009
    Applicant: ADVANCED LIFE SCIENCES, INC.
    Inventors: Ali Koohang, Aye Aye Mar, Erika Szotek, Ze-Qi Xu, David A. Eiznhamer, Michael T. Flavin
  • Synthetic pentacyclic triterpenoids and derivatives of betulinic acid and betulin
    Publication number: 20070232577
    Abstract: The present invention comprises small molecule inhibitors of cell proliferative conditions, in particular cancer and conditions associated with cancer. For example, associated malignancies include ovarian cancer, cervical cancer, breast cancer, colorectal cancer, and glioblastomas, among others. Accordingly, the compounds of the present invention are useful for treating, preventing, and/or inhibiting these diseases. Thus, the present invention also comprising pharmaceutical formulations comprising the compounds and methods of using the compounds and formulations to inhibit cancer and treat, prevent, or inhibit the foregoing diseases.
    Type: Application
    Filed: March 23, 2007
    Publication date: October 4, 2007
    Applicant: Advanced Life Sciences, Inc.
    Inventors: Ze-Qi Xu, Ali Koohang, Aye Aye Mar, Nathan Majewski, David Eiznhamer, Michael Flavin
  • Method for the preparation of (+)-calanolide A and analogues thereof
    Patent number: 5981770
    Abstract: A method of preparing (+)-calanolide A, 1, a potent HIV reverse transcriptase inhibitor, from chromene 4 is provided. According to the disclosed method, chromene 4 intermediate was subjected to a chlorotitanium-mediated aldol reaction with acetaldehyde to selectively produce (.+-.)-8a. Separation and enzyme-mediated resolution of (.+-.)-8a produced (+)-8a. Cyclization of (+)-8a under neutral Mitsunobu conditions followed by Luche reduction of (+)-7 produced (+)-calanolide A in high yield and enantiomeric purity. The method of the invention has been extended to produce potent antiviral calanolide A analogues.
    Type: Grant
    Filed: September 5, 1997
    Date of Patent: November 9, 1999
    Assignee: Sarawak MediChem Pharmaceuticals, Inc.
    Inventors: Michael T. Flavin, Ze-Qi Xu, Albert Khilevich, David Zembower, John D. Rizzo, Shuyuan Liao, Aye Mar, Lin Lin, Vilayphone Vilaychack, Darko Brankovic, Sergey Dzekhster, Jinjun Liu
  • Method for the preparation of (+)-calanolide A and analogues thereof
    Patent number: 5977385
    Abstract: A method of preparing (+)-calanolide A, 1, a potent HIV reverse transcriptase inhibitor, from chromene 4 is provided. According to the disclosed method, chromene 4 intermediate was subjected to a chlorotitanium-mediated aldol reaction with acetaldehyde to selectively produce (.+-.)-8a. Separation and enzyme-mediated resolution of (.+-.)-8a produced (+)-8a. Cyclization of (+)-8a under neutral Mitsunobu conditions followed by Luche reduction of (+)-7 produced (+)-calanolide A in high yield and enantiomeric purity. The method of the invention has been extended to produce potent antiviral calanolide A analogues.
    Type: Grant
    Filed: July 15, 1998
    Date of Patent: November 2, 1999
    Assignee: Sarawak MediChem Pharmaceuticals
    Inventors: Michael T. Flavin, Ze-Qi Xu, Albert Khilevich, David Zembower, John D. Rizzo, Shuyuan Liao, Aye Mar, Lin Lin, Vilayphone Vilaychack, Darko Brankovic, Sergey Dzekhster, Jinjun Liu
  • Method for the preparation of (+)-calanolide a and analogues thereof
    Patent number: 5892060
    Abstract: A method of preparing (+)-calanolide A, 1, a potent HIV reverse transcriptase inhibitor, from chromene 4 is provided. According to the disclosed method, chromene 4 intermediate was subjected to a chlorotitanium-mediated aldol reaction with acetaldehyde to selectively produce (.+-.)-8a. Separation and enzyme-mediated resolution of (.+-.)-8a produced (+)-8a. Cyclization of (+)-8a under neutral Mitsunobu conditions followed by Luche reduction of (+)-7 produced (+)-calanolide A in high yield and enantiomeric purity. The method of the invention has been extended to produce potent antiviral calanolide A analogues.
    Type: Grant
    Filed: March 1, 1996
    Date of Patent: April 6, 1999
    Assignee: Sarawak MediChem Pharmaceuticals, Inc.
    Inventors: Michael T. Flavin, Ze-Qi Xu, Albert Khilevich, David Zembower, John D. Rizzo, Shuyuan Liao, Aye Mar, Lin Lin, Vilayphone Vilaychak, Darko Brankovic, Sergey Dzekhster, Jinjun Liu
  • (+)-calanolide A and analogues thereof
    Patent number: 5872264
    Abstract: A method of preparing (+)-calanolide A, 1, a potent HIV reverse transcriptase inhibitor, from chromene 4 is provided. According to the disclosed method, chromene 4 intermediate was subjected to a chlorotitanium-mediated aldol reaction with acetaldehyde to selectively produce (.+-.)-8a. Separation and enzyme-mediated resolution of (.+-.)-8a produced (+)-8a. Cyclization of (+)-8a under neutral Mitsunobu conditions followed by Luche reduction of (.+-.)-7 produced (+)-calanolide A in high yield and enantiomeric purity. The method of the invention has been extended to produce potent antiviral calanolide A analogues.
    Type: Grant
    Filed: September 5, 1997
    Date of Patent: February 16, 1999
    Assignee: Sarawak MediChem Pharmaceuticals, Inc.
    Inventors: Michael T. Flavin, Ze-Qi Xu, Albert Khilevich, David Zembower, John D. Rizzo, Shuyuan Liao, Aye Mar, Lin Lin, Vilayphone Vilaychack, Darko Brankovic, Sergey Dzekhster, Jinjun Liu