Patents by Inventor Ayelet Dar

Ayelet Dar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170342384
    Abstract: Provided are methods of isolating pericyte progenitor cells from pluripotent stem cells such as embryonic stem cells and induced pluripotent stem cells, by isolating CD105+, CD73+ and/or CD105+/CD73+ cells from embryoid bodies and optionally by enriching the cells with CD31? cells. Also provided are methods of isolating endothelial cells and co-derivation of pericyte and endothelial cells progenitor cells from embryoid bodies, and methods of differentiating same for various therapeutic applications. In addition, the invention provides an isolated pericyte progenitor cell having an expression marker signature of CD105+/CD73+CD31?/alpha SMA?/CD133?/Flk-1?.
    Type: Application
    Filed: July 24, 2017
    Publication date: November 30, 2017
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Ayelet DAR-OAKNIN, Joseph ITSKOVITZ-ELDOR
  • Publication number: 20120148546
    Abstract: Provided are methods of isolating pericyte progenitor cells from pluripotent stem cells such as embryonic stem cells and induced pluripotent stem cells, by isolating CD105+, CD73+ and/or CD105+/CD73+ cells from embryoid bodies and optionally by enriching the cells with CD31? cells. Also provided are methods of isolating endothelial cells and co-derivation of pericyte and endothelial cells progenitor cells from embryoid bodies, and methods of differentiating same for various therapeutic applications. In addition, the invention provides an isolated pericyte progenitor cell having an expression marker signature of CD105+/CD73+CD31?/alpha SMA?/CD133?/Flk-1?.
    Type: Application
    Filed: August 17, 2010
    Publication date: June 14, 2012
    Applicant: Technion Research & Development Foundation Ltd.
    Inventors: Ayelet Dar-Oaknin, Joseph Itskovitz-Eldor
  • Patent number: 7214371
    Abstract: The invention is directed to tissue-engineered biografts, methods for preparing the biografts of the invention, and methods for repairing a damaged myocardium in a mammal. The methods of the invention can include providing a three-dimensional porous polysaccharide matrix; introducing mammalian cells into said matrix; growing said cells in said matrix in vitro, until a tissue-engineered biograft is formed; and transplanting the tissue-engineered biograft onto myocardial tissue or myocardial scar tissue of said mammal. The tissue-engineered biograft of the invention can form a contracting tissue. The methods of the invention can optionally include removing scar tissue or dead tissue from the site of implantation prior to transplanting the biograft.
    Type: Grant
    Filed: September 1, 2000
    Date of Patent: May 8, 2007
    Assignee: Ben-Gurion University of the Negev Research & Development Authority
    Inventors: Smadar Cohen, Ayelet Dar, Sharon Etzion, Anat Perets, Sigalit Shaprut, Jonathan Leor
  • Publication number: 20070014772
    Abstract: A method for repairing a damaged myocardium in a mammal, comprising: a) providing a three-dimensional porous polysaccharide matrix; b) introducing mammalian cells into said matrix; c) growing said cells in said matrix in vitro, until a tissue-engineered biograft is formed, comprising a contracting tissue; and d) transplanting the tissue-engineered biograft onto the myocardial tissue or myocardial scar tissue of said mammal, optionally previously removing scar or dead tissue from the site of implantation.
    Type: Application
    Filed: September 25, 2006
    Publication date: January 18, 2007
    Applicant: Ben-Gurion University of the Negev
    Inventors: Smadar Cohen, Ayelet Dar, Sharon Etzion, Anat Perets, Sigalit Shaprut, Jonathan Leor