Patents by Inventor Ayelet Erez

Ayelet Erez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AGENTS FOR SENSITIZING SOLID TUMORS TO TREATMENT
    Publication number: 20230293530
    Abstract: An agent which increases pyrimidine to purine ration in a cell without decreasing pyrimidine synthesis for use in a method of treating a solid tumor in a subject in need thereof, optionally in combination with an immune-modulating drug.
    Type: Application
    Filed: June 24, 2020
    Publication date: September 21, 2023
    Applicants: Yeda Research and Development Co. Ltd., The United States of America, as Represented by the Secretary, Department of Health and Human Servic
    Inventors: Ayelet EREZ, Rom KESHET, Lital ADLER, Eytan RUPPIN, Lee Joo SANG
  • METHODS OF DIAGNOSING AND PROGNOSING CANCER
    Publication number: 20200150125
    Abstract: Methods of diagnosing cancer are provided. Accordingly there is provided a method of diagnosing cancer in a subject, the method comprising determining a level of urea and/or a pyrimidine synthesis metabolite in a biological sample of the subject, wherein a level of urea below a predetermined threshold; and/or a said level of pyrimidine synthesis metabolite above a predetermined threshold; is indicative of cancer. Also provided are methods of prognosing and treating cancer.
    Type: Application
    Filed: March 12, 2018
    Publication date: May 14, 2020
    Applicant: Yeda Research and Development Co., Ltd.
    Inventor: Ayelet EREZ
  • COMBINATION THERAPY TO INCREASE ENDOGENOUS NITRIC OXIDE (NO) SYNTHESIS
    Publication number: 20190314312
    Abstract: Provided are uses of a therapeutically effective amount of citrulline for the manufacture of a medicament for treatment of a subject having an inflammatory bowel disease (IBD) and/or colon cancer. Also provided are pharmaceutical compositions comprising a therapeutic effective amount of citrulline and a therapeutically effective amount of a flavonoid for the treatment of an inflammatory bowel disease (IBD) and/or colon cancer and kits comprising same.
    Type: Application
    Filed: July 11, 2017
    Publication date: October 17, 2019
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Ayelet EREZ, Noa STETTNER
  • CITRIN INHIBITORS FOR THE TREATMENT OF CANCER
    Publication number: 20180161300
    Abstract: Provided are methods, pharmaceutical compositions and kits for treating cancer in a subject in need thereof, by administering to the subject a therapeutically effective amount of an agent which downregulates a mitochondrial aspartate-dependent pyrimidine synthesis, thereby treating the cancer.
    Type: Application
    Filed: May 10, 2016
    Publication date: June 14, 2018
    Applicant: Yeda Research and Development Co., Ltd.
    Inventors: Ayelet EREZ, Shiran RABINOVICH, Alon SILBERMAN, Shani AGRON
  • Pharmaceutical composition and method for regulating abnormal cellular proliferation
    Patent number: 8841266
    Abstract: A method of treating a disease associated with a cell population which proliferates abnormally in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of at least one modulator capable of modulating in the cell population a level and/or activity of a polypeptide having an amino acid sequence at least 60 percent similar to SEQ ID NO: 5, as determined using the Standard protein-protein BLAST [blastp] software of the NCBI.
    Type: Grant
    Filed: November 16, 2006
    Date of Patent: September 23, 2014
    Assignees: Tel Hashomer Medical Research Infrastructure and Services Ltd., The United States of America as represented by the Secretary of the Department of Health and Human Services National Institutes of Health Office of Technology Transfer
    Inventors: Shai Izraeli, Ilan R. Kirsch, Ayelet Erez, Stefano Campaner
  • Pharmaceutical Composition and Method for Regulating Abnormal Cellular Proliferation
    Publication number: 20100278797
    Abstract: A method of treating a disease associated with a cell population which proliferates abnormally in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of at least one modulator capable of modulating in the cell population a level and/or activity of a polypeptide having an amino acid sequence at least 60 percent similar to SEQ ID NO: 5, as determined using the Standard protein-protein BLAST [blastp] software of the NCBI.
    Type: Application
    Filed: November 16, 2006
    Publication date: November 4, 2010
    Applicant: Tel HaShomer Medical Research Infrastracture and Services Ltd.
    Inventors: Shai Izraeli, Ilan R. Kirsch, Ayelet Erez, Stefano Campaner