Patents by Inventor Ayelet Lesman

Ayelet Lesman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CELLULOSE SCAFFOLDS DERIVED FROM MACROALGAE, PROCESS FOR THE PREPARATION THEREOF AND USES THEREOF
    Publication number: 20230364302
    Abstract: Cellulose-based scaffolds having fibrous structures, which include a decellularized macroalgae tissue from which cellular materials and nucleic acids are removed; implants including such cellulose-based scaffolds; and a decellularization process for the preparation thereof. The macroalgae tissue may be a green macroalgae tissue, a red macroalgae tissue, or a brown macroalgae tissue. The green macroalgae tissue may be a Cladophora sp. tissue; and the red macroalgae tissue may be a Bangia sp. tissue.
    Type: Application
    Filed: May 11, 2023
    Publication date: November 16, 2023
    Inventors: Nurit Bar-Shai, Alexander Golberg, Ayelet Lesman, Orna Sharabani-Yosef
  • Tissue engineering construct comprising fibrin
    Patent number: 11045500
    Abstract: A three-dimensional fibrin engineered tissue construct is provided selected from: (i) a fibrin gel matrix comprising a combination of tissue-specific cells and at least one type of vascular cells; and (ii) a hybrid scaffold of fibrin gel and a polymeric synthetic scaffold comprising at least one type of vascular cells or a combination of tissue-specific cells and at least one type of vascular cells.
    Type: Grant
    Filed: February 13, 2012
    Date of Patent: June 29, 2021
    Assignee: TECHNION RESEARCH DEVELOPMENT FOUNDATION LTD.
    Inventors: Shulamit Levenberg, Ayelet Lesman
  • In vitro platform and methods for culturing embryos for implantation
    Patent number: 10213282
    Abstract: A mammalian in vitro system for culturing an embryo includes a collagen or fibrin matrix and endometrial and/or stromal cells. The in vitro platforms and methods according to embodiments of the invention allow for in vitro embryonic development (including implantation) prior to transfer of the embryo complex in vivo for further development.
    Type: Grant
    Filed: April 28, 2015
    Date of Patent: February 26, 2019
    Assignee: California Institute of Technology
    Inventors: Samuel Ojosnegros Martos, Carol Readhead, Ayelet Lesman
  • IN VITRO PLATFORM AND METHODS FOR CULTURING EMBRYOS FOR IMPLANTATION
    Publication number: 20150305774
    Abstract: A mammalian in vitro system for culturing an embryo includes a collagen or fibrin matrix and endometrial and/or stromal cells. The in vitro platforms and methods according to embodiments of the invention allow for in vitro embryonic development (including implantation) prior to transfer of the embryo complex in vivo for further development.
    Type: Application
    Filed: April 28, 2015
    Publication date: October 29, 2015
    Inventors: Samuel Ojosnegros Martos, Carol Readhead, Ayelet Lesman
  • TISSUE ENGINEERING CONSTRUCT COMPRISING FIBRIN
    Publication number: 20140050766
    Abstract: A three-dimensional fibrin engineered tissue construct is provided selected from: (i) a fibrin gel matrix comprising a combination of tissue-specific cells and at least one type of vascular cells; and (ii) a hybrid scaffold of fibrin gel and a polymeric synthetic scaffold comprising at least one type of vascular cells or a combination of tissue-specific cells and at least one type of vascular cells.
    Type: Application
    Filed: February 13, 2012
    Publication date: February 20, 2014
    Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.
    Inventors: Shulamit Levenberg, Ayelet Lesman
  • Vascularized cardiac tissue and methods of producing and using same
    Publication number: 20090169521
    Abstract: An isolated composition of matter is disclosed. The composition comprises a heterogeneous population of cells seeded on a scaffold, wherein the heterogeneous population of cells comprises cardiomyocytes, endothelial cells and fibroblast cells. Pharmaceutical compositions comprising same and uses thereof are also disclosed.
    Type: Application
    Filed: December 31, 2007
    Publication date: July 2, 2009
    Applicant: Technion Research & Development Foundation Ltd.
    Inventors: Shulamit Levenberg, Lior Gepstein, Ayelet Lesman, Oren Caspi